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Table 4 Activity of a novel series of benzimidazole derivatives (at 25 µM) for each Haemonchus contortus assay (incubation time of 72 h for xL3 or adult stage motility test and 7 days for L4 development test)

From: Sensitivity of Haemonchus contortus to anthelmintics using different in vitro screening assays: a comparative study

Compound IDa % of motility on xL3s (average ± SEM) % of L4 development (average ± SEM) Adult stage motility score (average ± SEM)
1a 93.1 ± 30.1 67.2 ± 4.9 2.2 ± 0.4
1b 131 ± 33.5 103.8 ± 9.6 1.5 ± 0.5d
1c 144.8 ± 39.5 106.1 ± 9.4 2.0 ± 0.0
1d 177.6 ± 56.1b 68.2 ± 18.4 0.1 ± 0.1d
1e 179.6 ± 49.9b 30.9 ± 15.1c 0.1 ± 0.1d
1f 113.8 ± 25.7 101.9 ± 5.4 2.0 ± 0.0
2a 193.1 ± 51.2b 111.2 ± 9.1 1.2 ± 1.1d
2b 131.0 ± 34.9 108.9 ± 6.7 2.3 ± 0.5
2c 134.5 ± 33.9 101.4 ± 13.6 1.4 ± 0.5d
3a 193.3 ± 32.3b 105.5 ± 7.4 2.2 ± 0.4
3b 156.7 ± 18.1b 100.0 ± 8.3 2.2 ± 0.4
ABZ e 29.4 ± 11.1b 0.6 ± 1.2c 1.0 ± 0.3d
  1. Bold numbers indicate that the compound was considered active
  2. aThe chemical synthesis and structure of the compounds was previously reported by [24]
  3. bMotility was significantly different from motility of DMSO control (P < 0.05) (see “Statistical analysis” section for further details)
  4. cDevelopment was significantly different from development of DMSO control (P < 0.05)) (see “Statistical analysis” section for further details)
  5. dMotility score of a compound at 72 h time point ≤ 1.5 is considered active[19]
  6. eABZ was evaluated at a concentration of 20 µM