Characterization of PSOP26 as an ookinete surface antigen with improved transmission-blocking activity when fused with PSOP25

Table 1 Prevalence and oocyst density in mosquitoes fed on WT and Δpsop26 parasites

Parasites	Infected/dissected	Infection prevalence^a (%)	Reduction in prevalence^b (%)	Oocyst density mean (range)^c	Reduction in oocyst density^d (%)
WT	29/30	96.7		115.2 (0–317)
Δpsop26-C1	19/29	65.5	31.2	24.9 (0–123)	78.4
Δpsop26-C2	20/30	66.7	30	21.4 (0–95)	81.4

^aThe infection prevalence was calculated based on the number of mosquitoes with oocysts/total mosquitoes dissected in each group × 100%
^bThe percentage reduction of prevalence was calculated as % mean prevalence_WT − % mean prevalence_Δpsop26
^cMean number and range of oocysts per mosquito midgut
^dThe percentage reduction in oocyst density was calculated as (mean oocyst density_WT − mean oocyst density_Δpsop26)/mean oocyst density_WT × 100%

ISSN: 1756-3305