Fig. 2

Differential expression analysis of lncRNAs in Plasmodium-infected mice. a Volcano plot filtering to visualize fold regulation and statistical significance in lncRNAs. Statistically significant (P < 0.05) upregulated (red) or downregulated (green) expression changes are shown in BALB/c mice infected with P.y17XL compared with normal control. b Hierarchical clustering of differentially expressed lncRNAs for uninfected vs. P.y17XL infection. Values in the color scale are normalized intensities. Red bands indicate high relative expression, and blue bands indicate low relative expression. Abbreviations: Con, Control; lncRNA, long non-coding RNA; TUCP, transcripts of uncertain coding potential