Fig. 3

a, b Differentially expressed (DE) transcripts of the immune serine protease (SP) cascade and tyrosine metabolism pathway of Rhodnius prolixus in response to bacterial injection. a Diagram representing the immune SP cascade of Manduca sexta (modified from An et al. [99] and Wang et al. [34]). Putative orthologs of identified SPs and SP inhibitors (SPIs) in R. prolixus are listed next to the M. sexta proteins. SPIs are represented as red hexagons next to the SPs they inhibit. Only SPI transcripts with identified orthologs in R. prolixus are displayed. b Diagram representing a simplified tyrosine metabolism pathway in R. prolixus (modified from Sterkel et al. [100]). Arrows represent the activation of processes or molecules. Underscored and bolded molecules are transcripts with differential expression in at least one comparison between two treatments. c Heat maps showing DE molecules from the immune SP cascade and tyrosine metabolism pathways in R. prolixus 8 and 24 hpi with PBS, Gr−, or Gr+ bacteria. Accession numbers are provided for annotated genes. The color of each cell corresponds to expression level. Displayed transcript expression values are the log 2 TMM average of the replicates of each treatment divided by the average TMM expression of all treatments. For raw TMM values, see Additional file 1. For other abbreviations, see Figs. 1 and 2