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Fig. 6 | Parasites & Vectors

Fig. 6

From: Structural analysis of PpSP15 and PsSP9 sand fly salivary proteins designed with a self-cleavable linker as a live vaccine candidate against cutaneous leishmaniasis

Fig. 6

The outputs of immune simulation using the C-ImmSim server for the vaccine candidate construct. The immunogenicity of the vaccine candidate construct was evaluated using the C-ImmSim server after three injections at time steps 1, 42, and 84, with 2-week intervals. a, c, e Cytokine responses. The level of cytokines is illustrated in the main plot. In addition, the inset plot indicates the IL-2 level and the diversity index (D). The low value of the D index (blue line) indicates the high diversity of clones. b, d, f (upper panel) T helper cell populations. The resting state implies cells not presented with the antigen, while duplicating state indicates cells in the mitotic cycle. The anergic state shows the T-cell tolerance to the antigen. b, d, f (bottom panel) the differentiated T cell clones. Negligible Th2 and Th17 clones are detected

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Parasites & Vectors

ISSN: 1756-3305

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