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Fig. 2 | Parasites & Vectors

Fig. 2

From: A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4–ROS–NLRP3 pathway

Fig. 2

rBsCPI-1 and BsES induced inflammasome activation. A Quantitative PCR analysis of the transcription levels of the NOD-like receptor 3 (NLRP3) inflammasome-related genes in MDMs. B, C A representative western blot band of ASC and cleaved N-terminal gasdermin D (GSDMD) are shown in B, and a graph of the quantified band density is shown in C. D The enzyme-linked immunosorbent assay (ELISA) detected the secreted IL-1β and IL-18 in the cell supernatant. E, F A representative western blotting band of retained IL-1β and IL-18 in the cells are shown in E, and the graph of the quantified band density is shown in F. Data are shown as mean ± SD of 3 replicates per group. Significant differences versus the control group are indicated by *P < 0.05, **P < 0.01, ***P < 0.001; versus pET-32a group by §P < 0.05, §§P < 0.01, §§§P < 0.001; versus the rBsCPI-1 group by &P < 0.05, &&P < 0.01, &&&P < 0.001; and versus the BsES group by #P < 0.05, ##P < 0.01, ###P < 0.001. GSDMD, Gasdermin D; IL, interleukin

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Parasites & Vectors

ISSN: 1756-3305

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