Fig. 5

Schistosoma mansoni HSP interaction networks. Identified S. mansoni HSPs were mapped using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database of predicted protein–protein interactions, embedded in Cytoscape for all HSPs and specific HSP (HSP 10, HSP 40, HSP 60, HSP 70 and HSP 90) families using a maximum of 100 additional interactors (proteins, nodes) for each query (seed) protein. Mapping of interactions (edges) was performed at high (0.7) confidence. Proteins coloured red within each network represent non-HSPs, with light blue and dark blue representing “other” HSPs and the HSP seed node, respectively. Out of a total of 55 S. mansoni HSPs, 42 were identified by the STRING database and were included in the analysis. The number of proteins identified per network that feature in a specific Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway is indicated for each network. ER Endoplasmic reticulum