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Table 4 Polymorphisms in B-cell epitopes of the Pvs230 gene from global isolates

From: Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

No

AA position

Sequence

S

NS

SP

π ± SD

 

H

Hd ± SD

dN–dS

1

E229–V275

EAGASDGVFDKVDEAFETTIKGDGNVLQASDPEVETFASSNTNKEYV

3

2

1

0.006 ± 0.000

 

6

0.590 ± 0.024

0.007

2

T333–A354

TLVNANEGSEEKKESLKEKRLA

0

0

0

0.000 ± 0.000

 

1

0.000 ± 0.000

0

3

E419–M448

EPYGQSVKGCNYTGKGKHFFSYDYEEGADM

1

0

1

0.000 ± 0.000

 

2

0.015 ± 0.010

− 0.001

4

N623–K649

NKAKYANLEMIPKMLKEEKKKKKNVLK

2

1

1

0.006 ± 0.000

 

3

0.457 ± 0.018

− 0.032

5

K693–N764

KKNSLFKNHKDSSYFDEVASPSDGFVKLLSFLDAQDTVILNEQVSDLTISTEQSTEDLFTLQLQIPPYITTN

3

3

0

0.001 ± 0.000

 

3

0.071 ± 0.021

0.001

6

N792–E818

NEHLVKGCNFSDGKMEHFTNNVGSTGE

1

0

1

0.000 ± 0.000

 

2

0.022 ± 0.012

− 0.001

7

K836–S851

KTVLPPSDEAEDSATS

1

1

0

0.001 ± 0.000

 

2

0.064 ± 0.020

0.002

  1. S, number of polymorphic (segregating) sites; NS, number of sites with non-synonymous polymorphisms; SP, number of sites with synonymous polymorphisms; π, nucleotide diversity; H, number of haplotypes; Hd, haplotype diversity; SD, standard deviation