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Table 5 Concentration–response statistics for all insecticides tested in WHO bottle assays and expected mortality or oviposition inhibition variability at the species level

From: A new WHO bottle bioassay method to assess the susceptibility of mosquito vectors to public health insecticides: results from a WHO-coordinated multi-centre study

Insecticide

Species

LC50 (median)

Range

LC99 (median)

Range

Variability of mortality (%)

95% Confidence interval

No. of locations

Clothianidin

Ae. aegypti

0.44

0.27–0.84

3.5

1.4–8.3

4.5

2.5–6.4

3

Ae. albopictus

0.62

0.18–1.2

3.5

1.8–4.7

5.6

1.9–8.9

3

Flupyradifurone

Ae. aegypti

4.9

0.58–17.5

45

12–170

12

6.6–16

3

Ae. albopictus

2.4

0.65–4.38

28

8–120

5.6

2.5–9.8

3

Metofluthrin

Ae. aegypti

0.21

0.08–0.32

0.49

0.26–0.59

6.9

4.9–10

3

Ae. albopictus

0.12

0.049–0.19

0.37

0.14–0.60

5.8

2.8–10.0

3

Prallethrin

Ae. aegypti

1.7

1.5–2.2

13.5

6.4–19

4.0

2.6–5.1

3

Ae. albopictus

2.4

0.5–3.9

7.6

1.6–13.7

4.8

2.9–6.4

3

Transfluthrin

Ae. aegypti

0.28

0.14–0.60

1.5

0.5–2.6

6.8

2.5–11

3

Ae. albopictus

0.35

0.031–0.55

0.82

0.14–1.5

7.8

3.1–10

3

Chlorfenapyr

An. albimanus

1.9

1.9–2.0

6

5.9–6.0

6.6

5.9–7.5

1

An. funestus

10

5.5–17

42

18–65

7.7

7.6–8.3

1

An. gambiae

14

2.2–21

120

37–1.8e+04

8.5

3.0–13

4

An. stephensi

1.5

0.38–6.6

200

16–820

3.4

1.3–5.1

2

Clothianidin

An. albimanus

0.19

0.055–0.45

1.8

0.88–46.8

6.9

4.1–9.6

2

An. funestus

0.26

0.06–0.60

5.6

0.48–11.9

9.8

4.4–15

2

An. gambiae

0.22

0.039–0.37

1.5

0.16–2.5

7.7

6.6–9.0

2

An. stephensi

0.71

0.52–1.0

2.9

1.8–23.1

6.9

5.9–8.5

3

Flupyradifurone

An. albimanus

44

14–68

150

130–290

8.3

6.8–10

2

An. funestus

11

11–11

43

43–43

2.8

1.9–4.9

1

An. gambiae

5.9

1.0–9.3

17

6.5–22

4.4

2.1–6.4

3

An. minimus

16

5.4–74

260

25–420

8.3

2.6–68

3

An. stephensi

5.0

0.9–9.2

33

4–34

9.7

4.3–19

3

Transfluthrin

An. albimanus

0.13

0.003–0.30

0.60

0.017–1.1

7.3

2.0–13

3

An. funestus

0.09

0.078–0.094

1.10

0.19–4.4

4.3

3.0–6.9

2

An. gambiae

0.11

0.04–0.16

0.69

0.13–1.4

5.2

4.0–6.3

3

An. minimus

0.15

0.013–0.18

0.58

0.31–0.83

1.6

1.1–2.6

2

An. stephensi

0.10

0.025–0.27

0.44

0.095–1.2

6.5

3.5–8.1

3

Insecticide

Species

OI50 (median)

Range

OI99 (median)

Range

OI % variability

95% CI

No. of locations

Pyriproxyfena

An. gambiae

7.6

0.25–10

62

1.5–110

2.5

6.6e−10–5.9

4

An. stephensi

10

0.74–71

800

5.1–1.6e+05

3.4

6.1e−12–7.5

3

  1. Model outputs at the insecticide-species-institution level were generated by computing the median of all model iterations. Summary statistics for each unique insecticide and species combination were generated from the mean of institution-level outputs (i.e. the median of all model iterations). The uncertainty around LC estimates was generated from the minimum and maximum (i.e. the range) bioassay-level estimates for each insecticide-species-institution combination. The mortality/OI variability was generated from the mean of institution-level estimates (generated as the median of all model iterations) per insecticide and species. The uncertainty around the variability estimate was provided by the 95% confidence intervals of the variability estimate: if multiple institutions contributed to the estimate for the insecticide-species combination, the minimum and maximum of these values were used to represent uncertainty; if only one institution informed the estimate, the actual 95% CIs around the median estimate are shown. The number of locations is the number of institutions for each combination (even if in the same country)
  2. LC50, LC50 Lethal concentration that kills 50% and 90%, respectively, of the test population
  3. aFor pyriproxyfen, estimates were based on the 50% and 99% oviposition inhibition (OI50 and OI99, respectively)
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Parasites & Vectors

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