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Table 5 Summary of the results for the evaluation of different doses of transfluthrin used in emanators across different species of Anopheles mosquitoes in the Ifakara large ambient chamber test, as measured using a landing method (human landing catch; HLC) and a biting method (blood-feeding)

From: Human landing catches provide a useful measure of protective efficacy for the evaluation of volatile pyrethroid spatial repellents

Mosquito species

Dosage

Landing experimenta

Biting experimentb

IRR landing vs biting

IRR (95% CI)

P-value

%PE (1-1RR)

IRR (95% CI)

P-value

%PE (1-1RR)

IRR (95% CI)

P-value

Overall

Overall

      

0.87 (0.81–0.93)

 < 0.001

Control

      

0.90 (0.82–0.97)

0.01

Transfluthrin

      

0.82 (0.74–0.91)

 < 0.001

Anopheles gambiae (Ifakara strain)

0 g

1.00

  

1.00

  

1

 

5 g

0.65 (0.47–0.88)

0.01

35

0.60 (0.44–0.82)

0.01

40

0.77 (0.63–0.94)

0.01

10 g

0.55 (0.40–0.72)

0.01

45

0.46 (0.33–0.66)

0.01

34

15 g

0.52 (0.38–0.72)

0.01

48

0.51 (0.36–0.74)

0.01

49

20 g

0.41 (0.28–0.61)

0.01

59

0.31 (0.11–0.51)

0.01

69

Anopheles gambiae (Kisumu strain; KDR)

0

1.00

  

1.00

  

1

 

5 g

0.56 (0.41–0.77)

0.01

44

0.68 (0.50–0.93)

0.01

32

0.97 (0.80–1.17)

 > 0.05

10 g

0.59 (0.43–0.81)

0.01

41

0.57 (0.41–0.81)

0.01

43

15 g

0.46 (0.32–0.65)

0.01

54

0.48 (0.34–0.69)

0.01

52

20 g

0.44 (0.32–0.64)

0.01

56

0.46 (0.31–0.69)

0.01

54

Anopheles funestus

0

1.00

  

1.00

  

1

 

5 g

0.76 (0.57–1.00)

0.01

34

0.70 (0.53–0.95)

0.01

30

0.75 (0.63–0.89)

 < 0.001

10 g

0.70 (0.52–0.92)

0.01

30

0.56 (0.40–0.77)

0.01

44

15 g

0.68 (0.50–0.90)

0.01

32

0.50 (0.36–0.69)

0.01

50

20 g

0.43 (0.30–0.62)

0.01

57

0.40 (0.26–0.60)

0.01

60

  1. Incidence rate ratio (IRR) was adjusted for temperature, humidity, volunteer, and compartment
  2. CI Confidence interval
  3. aEstimated by comparison between the treatment and the control for each dose of transfluthrin used in the HLC method
  4. bEstimated using the model comparing the transfluthrin treatment and control for the biting method, in which the mosquitoes were allowed to interact with the human volunteers and blood-feed