Human landing catches provide a useful measure of protective efficacy for the evaluation of volatile pyrethroid spatial repellents

Table 6 Summary of the results for the evaluation of different doses of transfluthrin used in emanators for Aedes aegypti mosquitoes in the I-LACT as measured using a landing method (HLC) or a biting method (blood-feeding)

Mosquito species	Dosage	Landing experiment^a			Biting experiment^b			IRR landing vs biting
Mosquito species	Dosage	IRR (95% CI)	P-value	%PE (1-1RR)	IRR (95% CI)	P-value	%PE (1-1RR)	IRR (95% CI)	P-value
Aedes aegypti	Overall							0.87 (0.81–0.93)	0.01
	Control							0.90 (0.82–0.97)	0.01
	Transfluthrin							0.82 (0.74–0.91)	0.01
Aedes aegypti	0 g	1.00			1.00			1.00
	5 g	0.74 (0.63–0.87)	0.01	26	0.47 (0.32–0.60)	0.01	53	0.63 (0.57–0.70)	0.01
	10 g	0.66 (0.52–0.85)	0.01	44	0.38( 0.31–0.47)	0.01	62
	15 g	0.37 (0.28–0.49)	0.01	67	0.24 (0.18–0.31)	0.01	74
	20 g	0.27 (0.19–0.36)	0.01	73	0.25 (0.19–0.32)	0.01	75

IRR adjusted for temperature, humidity, volunteer, and compartment
^aEstimated by comparison between the treatment and the control for each dose of transfluthrin used in the HLC method
^bEstimated using the model comparing the transfluthrin treatment and control for the biting method, in which the mosquitoes were allowed to interact with the human volunteers and blood-feed

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