Table 1 Hematological and biochemical parameters in a 6-year-old female-spayed European Shorthair cat imported from Spain to Germany infected with Leishmania infantum
From: Feline leishmaniosis with focus on ocular manifestation: a case report
Parameter | RI | Day 0 | Day 48 | Day 66 | Day 96 | Day 117 | Day 133 | Day 196 | Day 288 |
|---|---|---|---|---|---|---|---|---|---|
Hematology | |||||||||
RBCs (× 1012/l) | 5.0–10.0 | 5.82 | 5.97 | 6.07 | 6.85 | – | 7.74 | 8.08 | 7.94 |
Hemoglobin (g/l) | 90–150 | 96 | 83 | 80 | 79 | – | 85 | 86 | 85 |
Hematocrit (l/l) | 0.3–0.44 | 0.32 | 0.26 | 0.26 | 0.27 | – | 0.30 | 0.28 | 0.3 |
Reticulocytes (× 109/l) | < 60.0 | 64.6 | 47.3 | 77.9 | 86.3 | – | 51.9 | 38 | 40.5 |
CHr (pg) | > 11.5 | 16.9 | 16.4 | 15.1 | 13.0 | – | 14.0 | 13.3 | 14.7 |
WBCs (× 1012/l) | 6.0–11.0 | 13.7 | 11.3 | 7.9 | 12.8 | – | 11.7 | 10.8 | 12.4 |
Segmented (× 109/l) | 3.0–11.0 | 7.1 | 6.6 | 3.0 | 6.7 | – | 7.1 | 6.2 | 7.2 |
Bands (× 109/l) | < 0.6 | 0.0 | 0.0 | 0.0 | 0.0 | – | 0.0 | 0.0 | 0.0 |
Lymphocytes (× 109/l) | 1.0–4.0 | 5.9 | 3.6 | 4.0 | 4.2 | – | 4.0 | 3.5 | 4.0 |
Eosinophils (× 109/l) | 0.04–0.6 | 0.0 | 0.1 | 0.6 | 0.1 | – | 0.0 | 0.1 | 0.0 |
Monocytes (× 109/l) | 0.04–0.5 | 0.7 | 0.9 | 0.3 | 1.7 | – | 0.6 | 1.1 | 1.2 |
Hypochromasia | Negative | Neg. | Neg. | Pos. | Neg. | – | Neg. | Neg. | Neg. |
Anisocytosis | Negative | Neg. | Neg. | Neg. | Neg. | – | Neg. | Neg. | Neg. |
Platelets (× 109/l) | 180–550 | 175 | 337 | 391 | 189 | – | 311 | 240 | 257 |
Biochemistry | |||||||||
Alpha-Amylase (U/l) | < 1850.0 | 1291.0 | 1265.0 | 1211.0 | 1198.0 | 1311.0 | – | 1374.0 | 1384.0 |
DGGR-lipase (U/l) | < 26.0 | 18.3 | 20.7 | 25.0 | 27.2 | 32.0 | – | 24.5 | 16.4 |
Glucose (mmol/l) | 3.1–6.9 | 5.3 | 4.4 | 4.6 | 4.2 | 5.1 | – | 5.8 | 5.3 |
Fructosamine (µmol/l) | < 340.0 | 212.0 | 193.8 | 200.2 | 212.9 | 196.6 | – | 246.6 | 212.9 |
Triglycerides (mmol/l) | < 1.14 | 1.2 | 0.87 | 1.05 | 0.42 | 1.55 | – | 0.53 | 0.63 |
Cholesterol (mmol/l) | 1.8–3.9 | 5.1 | 4.9 | 4.6 | 4.7 | 4.2 | – | 4.4 | 3.5 |
Bilirubin (µmol/l) | < 3.4 | 1.1 | 0.5 | 2.2 | 2.3 | 1.8 | – | 2.1 | 3.6 |
ALP (U/l) | < 140.0 | 16.0 | 16.0 | 16.0 | 17.0 | 29.0 | – | 37.0 | 38.0 |
GLDH (U/l) | < 6.0 | 1.8 | 2.0 | 7.0 | 4.2 | 4.6 | – | 20.7 | 2.5 |
G-GT (U/l) | < 5.0 | < 0.1 | < 0.1 | < 0.1 | < 0.1 | < 0.1 | – | < 0.1 | 0.1 |
ALT (U/l) | < 70.0 | 18.2 | 24.3 | 44.5 | 32.7 | 59.3 | – | 230.5 | 99.6 |
AST (U/l) | < 30.0 | 20.9 | 12.4 | 20.7 | 16.4 | 26.6 | – | 61.6 | 43.3 |
Creatin kinase (U/l) | < 130.0 | 38.0 | 18.0 | 22.0 | 30.0 | 55.0 | – | 124.0 | 70.0 |
Total protein (g/l) | 57.0–94.0 | 85.9 | 89.9 | 97.2 | 101.2 | 100.7 | – | 103.7 | 98.8 |
Albumin (g/l) | 26.0–56.0 | 28.9 | 28.0 | 26.0 | 27.1 | 29.2 | – | 38.8 | 30.6 |
Globulin (g/l) | < 55.0 | 57.0 | 61.9 | 71.2 | 74.1 | 71.5 | – | 64.9 | 68.2 |
Urea (mmol/l) | 5.0–11.3 | 5.4 | 6.5 | 7.1 | 7.4 | 8.0 | – | 8.3 | 6.5 |
Creatinine (µmol/l) | < 168.0 | 92.0 | 106.0 | 80.0 | 94.0 | 104.0 | – | 124.0 | 117.0 |
Phosphorus (mmol/l) | 0.8–1.9 | 1.9 | 1.6 | 1.3 | 1.5 | 1.4 | – | 1.2 | 1.5 |
SDMA (µmol/l) | < 0.75 | – | – | 0.62 | 0.57 | 0.47 | – | 0.56 | 0.46 |
Magnesium (mmol/l) | 0.6–1.3 | 0.9 | 0.9 | 0.8 | 0.9 | 0.9 | – | 0.9 | 0.8 |
Calcium (mmol/l) | 2.3–3.0 | 2.7 | 2.4 | 2.3 | 2.3 | 2.4 | – | 2.5 | 2.3 |
Sodium (mmol/l) | 145.0–158.0 | 155.0 | 150.0 | 148.0 | 147.0 | 150.0 | – | 152 | 151 |
Potassium (mmol/l) | 3.0–4.8 | 5.0 | 4.5 | 4.2 | 4.7 | 4.4 | – | 4.3 | 4.1 |
Iron (µmol/l) | 8–31 | 7.9 | 7.5 | 5.3 | 6.0 | 5.7 | – | 6.5 | 5.5 |
Serum amyloid A (µg/l) | < 6.7 | 77.4 | 35.2 | 21.4 | 15.2 | 13.6 | – | 5.9 | 12.0 |
Pathogen detection methods | |||||||||
Leishmania IFAT | ≤ 1:64 | 1:4096 | 1:512 | 1:1024 | 1:1024 | 1:512 | 1:256 | 1:256 | 1:256 |
Leishmania ELISA | < 11 LE | – | – | – | – | 23.7 | – | 14.7 | 12.9 |
Leishmania qPCR (/ml) | – | 786 (pos) | 191 (pos) | 1 (pos) | 238 (pos) | 94 (pos) | – | 11 (pos) | 49 (pos) |