Table 1 In vitro activity (EC50 values [µM]) of anthelminthics against eggs of Necator americanus, Ancylostoma ceylanicum, and Heligmosomoides polygyrus, determined after 72 h of drug exposure
From: Development of a hookworm egg hatching assay to determine the ovicidal effects of anthelminthics
Drug family | Compound | N. americanus (unembryonated) | A. ceylanicum (unembryonated) | H. polygyrus (unembryonated) | H. polygyrus (embryonated) | |
|---|---|---|---|---|---|---|
EC50 [µM] (s.e.) | EC50 [µM] (s.e.) | EC50 [µM] (s.e.) | EC50 [µM] (s.e.) | |||
Benzimidazoles | Thiabendazole | 0.27 (0.02) | 0.27 (0.01) | 0.21 (0.01) | 0.41 (0.03) | |
Albendazole | 0.48 (0.03) | 0.40 (0.03) | 0.42 (0.01) | 0.49 (0.03) | ||
Oxibendazole | 2.6 (0.3) | 1.53 (0.11) | 0.70 (0.01) | 1.43 (0.08) | ||
Mebendazole | 4.9 (0.3) | 1.15 (0.13) | 4.6 (0.1) | 8.4 (1.1) | ||
Flubendazole | 3.6 (3.5) | 32.9 (3.3) | 4.9 (0.3) | 8.9 (0.6) | ||
Albendazole sulfoxide | > 100 | > 100 | > 100 | > 100 | ||
Fenbendazole | > 100 | > 100 | > 100 | > 100 | ||
Oxfendazole | > 100 | > 100 | > 100 | > 100 | ||
Macrolides | Abamectin | > 100 | > 100 | > 100 | > 100 | |
Doramectin | > 100 | > 100 | > 100 | > 100 | ||
Eprinomectin | > 100 | > 100 | > 100 | > 100 | ||
Ivermectin | > 100 | > 100 | > 100 | > 100 | ||
Milbemycin oxime | > 100 | > 100 | > 100 | > 100 | ||
Moxidectin | > 100 | > 100 | > 100 | > 100 | ||
Miscellaneous | Monepantel | 51.4 (33.8) | 1.05 (0.09) | > 100 | 1.86 (0.42) | |
Levamisole | 12.6 (1.9) | 5.6 (0.5) | 14.9 (1.0) | 5.1 (0.5) | ||
Tribendimidine | 44.4 (5.7) | > 100 | 85.3 (4.8) | 48.4 (12.5) | ||
Emodepside | > 100 | > 100 | > 100 | > 100 | ||
Oxantel pamoate | > 100 | > 100 | > 100 | > 100 | ||
Pyrantel pamoate | > 100 | > 100 | > 100 | > 100 | ||