Table 3 Expression of drug targets in male H. bakeri

Macrocyclic lactones

GluCl

glc-1

HPOL_0001177601-mRNA-1

3.91

3.06E−09

8.84

1.24E−02

4.52

1.03E−04

2.74

glc-2

HPOL_0001003101-mRNA-1

1.32

7.05E−01

1.62

3.71E−01

1.33

3.69E−01

1.75

HPOL_0001839701-mRNA-1

0.60

5.95E−02

0.93

4.26E−01

0.56

1.94E−01

0.79

glc-3

HPOL_0000126101-mRNA-1

2.03

4.84E−09

1.34

2.92E−04

0.64

2.52E−01

0.80

avr-14

HPOL_0000096601-mRNA-1

1.67

5.20E−07

0.93

2.84E−01

0.55

2.89E−01

0.73

avr-15

HPOL_0001177601-mRNA-1

3.91

3.06E−09

8.84

1.24E−02

4.52

1.03E−04

2.74

Piperazine

GABA

unc-49

HPOL_0000247101-mRNA-1

7.52

2.81E−07

5.06

6.81E−01

3.31

2.35E−02

4.74

Imidazothiazoles, tetrahydropyrimidine, tribendimidine, spiroindoles

nACHR

lev-1

HPOL_0001059501-mRNA-1

9.09

2.15E−13

4.73

5.22E−03

2.31

8.67E−04

3.91

lev-8

HPOL_0000812201-mRNA-1

0.21

1.40E−01

0.14

3.13E−04

0.39

2.72E−03

0.10

unc-29

HPOL_0000079901-mRNA-1

19.38

1.25E−13

12.55

2.39E−01

7.86

1.47E−01

9.66

HPOL_0001278501-mRNA-1

1.83

1.56E−06

1.06

2.62E−01

0.62

9.41E−01

0.61

HPOL_0001278801-mRNA-1

0.16

2.73E−01

0.29

6.50E−02

0.08

NA

0.11

HPOL_0002208401-mRNA-1

0.12

8.02E−01

0.12

9.95E−01

0.09

NA

0.16

HPOL_0000080001-mRNA-1

9.12

5.53E−48

1.75

4.33E−04

1.89

7.59E−01

1.84

unc-38

HPOL_0000053201-mRNA-1

19.64

2.05E−12

12.28

1.04E−01

7.34

9.81E−01

7.67

unc-63

HPOL_0000939601-mRNA-1

6.62

8.10E−03

6.07

2.48E−01

3.91

7.38E−02

3.25

AADs

Choline receptors

acr-23

HPOL_0000939601-mRNA-1

6.62

8.10E−03

6.07

2.48E−01

3.91

7.38E−02

3.25

deg-3

HPOL_0000510801-mRNA-1

2.00

3.97E−04

1.58

8.63E−02

0.92

1.12E−01

1.19

des-2

HPOL_0000510601-mRNA-1

3.22

2.36E−02

2.88

1.90E−01

1.75

1.71E−01

2.23

HPOL_0000510701-mRNA-1

5.27

6.61E−04

4.19

3.59E−01

2.64

5.60E−01

3.05

Cyclic depsipeptides

Potassium channels

slo-1

HPOL_0000350101-mRNA-1

14.86

5.42E−04

22.46

3.73E−05

22.22

8.57E−03

17.53

Cyclic depsipeptides

Latrophilin receptors

lat-1

HPOL_0001283901-mRNA-1

31.93

4.06E−01

32.41

2.28E−01

19.90

8.21E−01

18.55

Benzimidazole

TBBs

ben-1

HPOL_0000661601-mRNA-1

1243.07

8.60E−07

1025.66

9.86E−08

1004.27

4.10E−01

966.08

HPOL_0000662001-mRNA-1

343.07

5.49E−61

140.36

2.06E−02

84.42

1.12E−03

67.44

Of interest^a

Neuropeptide GPCRs

pdfr-1

HPOL_0000292001-mRNA-1

2.36

5.83E−04

1.35

3.85E−01

1.25

1.39E−01

0.77

pcdr-1

HPOL_0000775801-mRNA-1

18.52

7.19E−07

13.93

8.18E−06

14.11

4.57E−01

13.29

npr-11

HPOL_0001846201-mRNA-1

1.70

9.22E−01

1.96

1.13E−02

1.80

3.93E−01

1.63

fshr-1

HPOL_0000573301-mRNA-1

8.24

6.14E−01

8.85

1.91E−03

4.57

9.84E−02

3.81

HPOL_0000675901-mRNA-1

6.95

4.02E−01

6.88

8.55E−02

3.70

8.81E−01

3.65

npr-5

HPOL_0000717801-mRNA-1

24.43

6.72E−06

17.02

8.11E−02

9.90

3.20E−02

13.66

npr-4

HPOL_0000350501-mRNA-1

1.92

3.17E−04

1.40

5.82E−16

0.30

1.04E−01

0.46

npr-10

npr-8

npr-9

frpr-7

HPOL_0000332701-mRNA-1

1.02

7.52E−01

1.26

1.72E−02

0.48

7.84E−01

0.60

HPOL_0001927801-mRNA-1

0.45

7.14E−01

0.55

1.94E−02

0.23

8.00E−01

0.27

frpr-18

HPOL_0002147401-mRNA-1

1.16

7.19E−01

1.39

5.30E−01

0.89

9.96E−01

0.93

HPOL_0002202601-mRNA-1

0.50

2.10E−01

0.73

1.61E−01

0.66

6.34E−01

0.59

HPOL_0002243501-mRNA-1

0.11

4.07E−01

0.19

3.40E−01

0.20

3.44E−01

0.11

dmsr-1

HPOL_0001923201-mRNA-1

8.73

4.44E−01

10.74

2.60E−04

5.43

8.92E−03

7.48

daf-38

dmsr-7

HPOL_0000318201-mRNA-1

4.13

5.95E−01

5.81

2.23E−02

1.82

9.52E−01

2.09

frpr-5

HPOL_0000014001-mRNA-1

236.59

1.51E−03

183.85

1.30E−05

210.49

6.68E−01

203.18

frpr-19

HPOL_0000877201-mRNA-1

27.56

9.51E−10

16.61

5.37E−07

6.86

1.98E−01

8.58

gnrr-1

HPOL_0000032901-mRNA-1

1.33

5.26E−02

0.90

7.58E−07

2.51

8.04E−02

1.27

sprr-1

HPOL_0000343501-mRNA-1

0.67

3.01E−02

0.51

8.15E−02

0.25

9.86E−01

0.27

ckr-2

npr-16

frpr-9

HPOL_0001450601-mRNA-1

3.79

5.57E−01

5.08

2.80E−01

5.31

8.48E−02

2.77