Table 4 Expression of drug targets in female H. bakeri

Macrocyclic lactones

GluCl

glc-1

HPOL_0001177601-mRNA-1

2.55

3.14E−01

2.56

4.27E−112

0.26

8.09E−01

0.28

glc-2

HPOL_0001003101-mRNA-1

1.53

2.35E−01

1.66

1.54E−09

0.85

9.28E−04

1.58

HPOL_0001839701-mRNA-1

0.96

4.64E−01

0.96

4.88E−10

0.49

6.14E−01

0.60

glc-3

HPOL_0000126101-mRNA-1

2.43

2.45E−02

1.68

3.84E−59

0.49

9.32E−01

0.53

avr-14

HPOL_0000096601-mRNA-1

1.28

3.64E−02

0.80

1.45E−16

2.62

9.90E−01

2.77

avr-15

HPOL_0001177601-mRNA-1

2.55

3.14E−01

2.56

4.27E−112

0.26

8.09E−01

0.28

Piperazine

GABA

unc-49

HPOL_0000247101-mRNA-1

9.40

1.13E−03

5.78

3.95E−38

2.04

2.32E−03

3.18

Imidazothiazoles, tetrahydropyrimidine, tribendimidine, spiroindoles

nACHR

lev-1

HPOL_0001059501-mRNA-1

9.90

1.59E−05

5.35

3.15E−57

1.27

1.61E−01

1.69

lev-8

HPOL_0000812201-mRNA-1

0.10

3.17E−11

0.86

4.40E−09

4.97

9.96E−01

5.25

unc-29

HPOL_0000079901-mRNA-1

19.00

1.58E−01

14.56

5.55E−98

4.17

1.89E−01

3.88

HPOL_0001278501-mRNA-1

1.67

7.87E−02

1.11

9.81E−39

0.23

5.16E−01

0.20

HPOL_0001278801-mRNA-1

0.17

7.20E−02

0.05

1.16E−02

0.01

NA

0.01

HPOL_0002208401-mRNA-1

0.19

5.18E−01

0.11

3.23E−04

0.01

NA

0.02

HPOL_0000080001-mRNA-1

3.99

1.08E−10

1.52

5.56E−05

1.13

1.48E−08

0.54

unc-38

HPOL_0000053201-mRNA-1

22.93

7.43E−11

11.33

5.47E−92

2.89

6.94E−01

3.23

unc-63

HPOL_0000939601-mRNA-1

7.12

2.38E−01

6.90

2.04E−37

19.16

2.59E−06

28.98

AADs

Choline receptors

acr-23

HPOL_0000939601-mRNA-1

7.12

2.38E−01

6.90

2.04E−37

19.16

2.59E−06

28.98

deg-3

HPOL_0000510801-mRNA-1

2.88

7.91E−22

0.93

3.38E−65

0.16

1.99E−03

0.29

des-2

HPOL_0000510601-mRNA-1

4.79

2.50E−15

1.86

3.84E−63

0.35

3.69E−02

0.54

HPOL_0000510701-mRNA-1

7.38

2.99E−18

2.61

1.21E−66

0.51

8.04E−01

0.58

Cyclic depsipeptides

Potassium channels

slo-1

HPOL_0000350101-mRNA-1

7.88

3.13E−05

9.75

2.17E−81

43.43

3.15E−10

28.62

Cyclic depsipeptides

Latrophilin receptors

lat-1

HPOL_0001283901-mRNA-1

37.69

8.75E−04

50.16

6.33E−03

79.58

8.40E−01

81.43

Benzimidazole

TBBs

ben-1

HPOL_0000661601-mRNA-1

1321.16

1.68E−20

632.90

4.77E−08

1014.55

9.91E−01

1077.80

HPOL_0000662001-mRNA-1

280.90

8.85E−01

240.71

8.45E−04

342.77

9.67E−01

365.69

Of interest^a

Neuropeptide GPCRs

pdfr-1

HPOL_0000292001-mRNA-1

2.80

8.30E−01

2.58

1.72E−15

11.73

9.17E−01

12.89

pcdr-1

HPOL_0000775801-mRNA-1

15.63

7.88E−01

14.02

3.28E−08

24.64

2.19E−02

32.22

npr-11

HPOL_0001846201-mRNA-1

2.12

1.23E−18

4.64

8.17E−79

0.98

5.33E−01

0.93

fshr-1

HPOL_0000573301-mRNA-1

13.07

7.91E−01

10.97

1.81E−08

8.27

8.60E−01

8.55

HPOL_0000675901-mRNA-1

12.42

2.48E−01

8.96

5.23E−12

4.74

7.47E−01

5.38

npr-5

HPOL_0000717801-mRNA-1

25.61

3.44E−06

13.28

2.59E−01

17.56

6.37E−01

20.15

npr-4

HPOL_0000350501-mRNA-1

1.36

7.05E−01

1.26

1.11E−29

0.40

5.48E−03

0.26

npr-10

npr-8

npr-9

frpr-7

HPOL_0000332701-mRNA-1

1.83

5.45E−02

1.01

9.75E−12

0.30

4.69E−01

0.42

HPOL_0001927801-mRNA-1

0.92

1.79E−01

0.58

1.09E−10

0.20

7.28E−01

0.19

frpr-18

HPOL_0002147401-mRNA-1

1.45

4.02E−01

1.42

5.12E−10

0.88

7.03E−06

0.49

HPOL_0002202601-mRNA-1

0.68

3.84E−01

0.71

2.47E−05

0.43

6.38E−03

0.23

HPOL_0002243501-mRNA-1

0.17

2.81E−01

0.25

1.66E−04

0.07

1.95E−01

0.02

dmsr-1

HPOL_0001923201-mRNA-1

13.94

9.97E−01

12.08

5.47E−140

1.99

2.88E−02

2.67

daf-38

dmsr-7

HPOL_0000318201-mRNA-1

4.97

8.99E−01

4.07

4.20E−08

1.05

9.91E−01

1.11

frpr-5

HPOL_0000014001-mRNA-1

281.27

7.71E−02

308.84

3.76E−16

159.23

4.37E−02

129.39

frpr-19

HPOL_0000877201-mRNA-1

28.02

1.19E−06

14.43

4.71E−29

6.12

6.33E−02

8.20

gnrr-1

HPOL_0000032901-mRNA-1

1.05

2.54E−03

2.05

1.07E−29

27.44

9.68E−01

28.57

sprr-1

HPOL_0000343501-mRNA-1

0.76

5.69E−01

0.58

7.87E−18

0.16

9.41E−02

0.10

ckr-2

npr-16

frpr-9

HPOL_0001450601-mRNA-1

2.78

1.21E−06

8.13

4.34E−16

52.54

6.94E−01

64.31