Skip to main content

Table 4 Relationship between the kdr mutant gene and insecticide resistance in An. sinensis

From: Insecticide resistance of Anopheles sinensis after elimination of malaria in Henan Province, China

Sampling sites/populations

Insecticide

Statusa

Sample size (n)

Allele frequency, n (%)b

Odds ratio (95% CI)

L1014L

L1014F

L1014C

L1014W

L1014F

L1014C

L1014W

Pingqiao

Beta-cyfluthrin

CR

34

18 (26.47)

47 (69.12)

3 (4.41)

0 (0.00)

2.80* (1.33,5.88)

0.20* (0.05,0.78)

NC

S

27

19 (35.19)

24 (44.44)

10 (18.52)

1 (1.85)

Deltamethrin

CR

11

8 (36.36)

11 (50.00)

3 (13.64)

0 (0.00)

1.00 (0.33,3.00)

0.52 (0.12,2.29)

NC

S

15

8 (26.67)

15 (50.00)

7 (23.33)

0 (0.00)

Total

–

87

53 (31.17)

97 (53.39)

23 (14.97)

1 (0.46)

–

–

–

Tanghe

Beta-cyfluthrin

CR

15

19 (63.33)

9 (30.00)

2 (6.67)

0 (0.00)

5.86* (1.43,23.96)

3.07 (0.27,35.49)

NC

S

22

40 (90.91)

3 (6.82)

1 (2.27)

0 (0.00)

Deltamethrin

CR

24

38 (79.17)

7 (14.58)

3 (6.25)

0 (0.00)

NC

1.13 (0.11,11.66)

NC

S

9

17 (94.44)

0 (0.00)

1 (5.56)

0 (0.00)

Total

–

70

114 (81.96)

19 (12.85)

7 (5.19)

0 (0.00)

–

–

–

Xiangcheng

Beta-cyfluthrin

CR

24

39 (81.25)

6 (12.50)

3 (6.25)

0 (0.00)

1.43 (0.38,5.44)

1.40 (0.22,8.80)

NC

S

22

38 (86.36)

4 (9.09)

2 (4.55)

0 (0.00)

Deltamethrin

CR

31

50 (80.65)

8 (12.90)

4 (6.45)

0 (0.00)

1.41 (0.40,5.01)

0.66 (0.15,2.78)

NC

S

21

34 (80.95)

4 (9.52)

4 (9.52)

0 (0.00)

Total

–

98

161 (82.30)

22 (11.00)

13 (6.69)

0 (0.00)

–

–

–

Xiangfu

Beta-cyfluthrin

CR

32

3 (4.69)

58 (90.63)

3 (4.69)

0 (0.00)

4.39* (1.14,16.96)

0.11* (0.02,0.52)

NC

S

8

0 (0.00)

11 (68.75)

5 (31.25)

0 (0.00)

Deltamethrin

CR

32

2 (3.13)

60 (93.75)

2 (3.13)

0 (0.00)

NC

NC

NC

 

S

12

0 (0.00)

24 (100.00)

0 (0.00)

0 (0.00)

Total

–

84

5 (1.95)

153 (88.28)

10 (9.77)

0 (0.00)

–

–

–

Total

–

–

339

333 (49.35)

291 (41.38)

53 (9.15)

1 (0.12)

–

–

–

  1. kdr Knockdown resistance gene, NC not calculated
  2. *P < 0.05
  3. aCR, Confirmed resistance (mortality < 90%); PR, possible resistance (90% ≤ mortality ≤ 97%); S, susceptible (mortality ≥ 98%)
  4. bL1014F represents a mutated allele from leucine to phenylalanine at codon 1014 of the para sodium ion channel gene; L1014C is a mutated allele from leucine to cysteine; L1014W leads to a leucine to tryptophan substitution; and L1014L is the wild-type allele
Back to article page

Parasites & Vectors

ISSN: 1756-3305

Contact us