Fluralaner systemic treatment of chickens results in mortality in Triatoma gerstaeckeri, vector of the agent of Chagas disease

Table 3 Concentrations of product active ingredients in chicken blood sample

Product	DPT	Repetition^a	N^b	Concentration (ng/ml)^c	Engorgement^d	Survival time (days)^d
Fluralaner	3	1	2	43.05	2.0	3.5
		2	1	4.45	3.0	3
		3	3	LOQ	3.0	2
	7	1	2	65.9	1.0	7.5
		2	3	2.52	3.0	8.3
		3	3	93.55	1.7	5.3
	14	1	1	24.92	3.0	11
		2	3	LOQ	1.7	10
		3	2	5.40	3.0	11
	28	1	2	LOQ	2.5	11
		2	2	LOQ	2.5	11
		3	3	LOQ	3.0	11
	56	1	3	LOQ	2.7	11
		2	3	LOQ	2.3	11
		3	2	LOQ	2.0	11
Fenbendazole	3	1	3	LOQ	2.0	11
		2	3	LOQ	2.0	11
		3	3	LOQ	3.0	11
	7	1	2	LOQ	2.0	11
		2	2	LOQ	2.5	11
		3	3	LOQ	3.0	11
	14	1	2	LOQ	3.0	11
		2	2	LOQ	2.0	11
		3	3	LOQ	2.0	11
	28	1	0	LOQ	NA^e	NA^e
		2	3	LOQ	2.0	11
		3	3	LOQ	2.0	11
	56	1	2	LOQ	3.0	11
		2	3	LOQ	3.0	11
		3	1	LOQ	3.0	11

DPT Days post-treatment
^aTotal of 3 repetitions of each trial
^bNumber of triatomines that fed on chicken
^cLOQ = less than the limit of quantification. Fluralaner: 2.5 ng/ml; fenbendazole: 5 ng/ml
^dMean of the fed triatomines
^eNot applicable; no triatomines took a blood meal from this chicken

ISSN: 1756-3305