Fluralaner (Bravecto®) treatment kills Aedes aegypti after feeding on Dirofilaria immitis-infected dogs

Parasites & Vectors

Table 2 Mean (arithmetic) counts of live mosquitoes 6 h (h), 24 h, 48 h, and 72 h after feeding on non-treated (n = 3)^a and fluralaner-treated (n = 4) heartworm-infected, microfilaremic dogs

Days after treatment	Live, fed mosquitoes	6 h	24 h	48 h	72 h
2
Control	95.7	94.7	63.3	13.7	8.7
Fluralaner	101.3	0	0	0	0
P-value		< 0.0001^b	< 0.0001^b	0.0009^b	0.0225^b
30
Control	90.7	89.3	69.3	13.3	11.0
Fluralaner	85.0	3.3	0.5	0.3	0.3
P-value		< 0.0001^b	< 0.0001^b	< 0.0001^b	0.0001^b
56
Control	86.3	86.0	67.7	33.7	24.3
Fluralaner	95.3	21.8	0	0	0
P-value		0.0276^b	0.0006^b	0.0082^b	0.0165^b
84
Control	92.7	92.7	68.7	24.0	15.0
Fluralaner	94.8	78.0	1.5	1.0	1.0
P-value		0.2183	< 0.0001^b	0.0019^b	< 0.0001^b

Student’s t-tests were performed to determine significant differences between groups. Regardless of treatment group, mosquito survival decreased upon infection with high numbers of microfilaria from infected dogs
^aOne non-treated dog stayed microfilaria-negative throughout, leading to improved mosquito survival; data from this dog was not included in the above calculations
^bIndicates significant difference between control and fluralaner-treated mean live mosquito counts

ISSN: 1756-3305