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Table 3 Percent survival (and 95% confidence intervals) of mosquitoes at 6 h, 24 h, 48 h, and 72 h after feeding on non-treated control (n = 3)a or fluralaner-treated (n = 4) heartworm-infected, microfilaremic dogs

From: Fluralaner (Bravecto®) treatment kills Aedes aegypti after feeding on Dirofilaria immitis-infected dogs

Days after treatment

6 h

24 h

48 h

72 h

2

Control

99.0% (96.8–99.8)

66.2% (60.5–71.4)

14.3% (10.7–18.8)

9.1% (6.2–13.0)

Fluralaner

0% (0.0–1.1)

0% (0.0–1.1)

0% (0.0–1.1)

0% (0.0–1.1)

30

    

Control

98.5% (96.1–99.6)

76.5% (71.1–81.1)

14.7% (11.0–19.4)

12.1% (8.7–16.6)

Fluralaner

3.8% (2.2–6.5)

0.6% (0.0–2.3)

0.3% (0.0–1.8)

0.3% (0.0–1.8)

56

Control

99.6% (97.6–100.0)

78.4% (73.0–83.0)

39.0% (33.3–45.1)

28.2% (23.1–34.0)

Fluralaner

22.8% (18.9–27.3)

0% (0.0–1.2)

0% (0.0–1.2)

0% (0.0–1.2)

84

Control

100% (98.4–100.0)

74.1% (68.6–78.9)

25.9% (21.1–31.4)

16.2% (12.3–21.0)

Fluralaner

82.3% (78.2–85.9)

1.6% (0.6–3.5)

1.1% (0.3–2.8)

1.1% (0.3–2.8)

  1. aOne non-treated dog stayed microfilaria-negative throughout, leading to improved mosquito survival; data from this dog were not included in the above calculations