Table 2 Information on some of the dysregulated pathways and related metabolites
From: Metabolomics analysis of visceral leishmaniasis based on urine of golden hamsters
Infection time | Pathway | Metabolite | Ionic strength changea | Mode | |
|---|---|---|---|---|---|
4 WPI | 12 WPI | ||||
4 WPI | Alanine, aspartate and glutamate metabolism | Citrate | 2.22 (0.041) | − 0.69 (N) | ESI− |
l-Glutamine | 2.47 (0.048) | − 0.88 (N) | ESI+ | ||
d-Glucosamine 6-phosphate | 2.03 (0.017) | − 0.89 (N) | ESI+ | ||
Pentose phosphate pathway | Δ-Gluconic acid δ-lactone | 2.5 (0.009) | − 0.69 (N) | ESI− | |
Gluconic acid | 2.02 (0.003) | − 0.79 (N) | ESI− | ||
Tryptophan metabolism | 5-Hydroxy-l-tryptophan | − 0.63 (0.008) | 1.56 (0.032) | ESI+ | |
5-Hydroxyindole-3-acetic acid | − 0.57 (0.050) | 1.34 (N) | ESI− | ||
Tyrosine metabolism | 2,5-Dihydroxybenzaldehyde | 1.94 (0.009) | − 0.5 (N) | ESI− | |
Noradrenaline | 1.67 (0.002) | − 0.85 (N) | ESI+ | ||
Glyoxylate and dicarboxylate metabolism | Citrate | 2.22 (0.041) | −0.69 (N) | ESI− | |
l-Glutamine | 2.47 (0.048) | − 0.88 (N) | ESI+ | ||
12 WPI | Tyrosine metabolism | Dl-Metanephrine | 1.35 (N) | − 0.63 (0.030) | ESI+ |
l-Dopa | − 0.97 (N) | 1.67 (0.022) | ESI+ | ||
2,5-Dihydroxybenzoate | − 0.91 (N) | 1.63 (0.040) | ESI− | ||
Tryptophan metabolism | 5-Hydroxy-l-tryptophan | − 0.63 (0.008) | 1.56 (0.032) | ESI+ | |
N-Acetylserotonin | − 0.8 (N) | 5.48 (0.006) | ESI+ | ||
Taurine and hypotaurine metabolism | Taurine | 1.26 (N) | 1.91 (0.036) | ESI+ | |
− 0.92 (N) | 2.31 (0.015) | ESI− | |||