Quantitative proteomic analysis of local and systemic extracellular vesicles during Eimeria falciformis infectious cycle in the host

Table 1 Differentially expressed immune- and cell death-associated protein in serum-derived extracellular vesicles

Protein ID	Gene name	Protein description	Coverage (%)	Unique peptides (n)	Sequence alignment score	FC
Protein ID	Gene name	Protein description	Coverage (%)	Unique peptides (n)	Sequence alignment score	sEVs, 0/68 hpi	sEVs, 0/116 hpi	sEVs, 0/7 dpi	sEVs, 0/10 dpi
P04223	H2-K1	H-2 class I histocompatibility antigen	10	2	34.8	1.54	2.11	1.67
P14426	H2-D1	H-2 class I histocompatibility antigen	15	2	57.72	1.65	2.22	1.51	0.6
P11672	Lcn2	Neutrophil gelatinase-associated lipocalin	26	5	25.89	ND	2.01	4.35	2.38
P08607	C4bpa	C4b-binding protein	36	15	269.56	ND	2.27	2.02	1.62
Q9Z0M9	Il18bp	Interleukin-18-binding	6	1	8.12	ND	1.64	ND	0.62
P10810	Cd14	Monocyte differentiation antigen CD14	19	6	28.9	ND	ND	2.69	ND
Q9Z121	Ccl8	C-C motif chemokine 8	59	4	21.2	ND	ND	1.61	ND
Q9ESY9	Ifi30	Gamma-interferon-inducible lysosomal thiol reductase	4	1	3.03	ND	1.5	ND	ND
Q61730	Il1rap	Interleukin-1 receptor	16	8	12.54	ND	0.52	0.52	0.59
O08688	Capn5	Calpain-5 accessory protein	25	16	158.62	0.61	0.52	0.4	0.22
P12399	Ctla2a	Protein CTLA-2-alpha	26	3	9.88	0.61	0.5	0.52	0.23
P70445	Eif4ebp2	Eukaryotic translation initiation factor 4E-binding	5	1	2.01	0.48	0.47	0.42	0.15
Q9WU78	Pdcd6ip	Programmed cell death 6-interacting protein	14	11	24.09	ND	0.59	0.61	0.54
Q8CJ96	Rassf8	Ras association domain- containing protein 8	3	1	7.08	ND	0.56	0.33	0.18
P06683	C9	Complement component C9	59	29	267.09	0.45	ND	0.49	0.2
Q01279	Egfr	Epidermal growth factor receptor	25	27	207.31	0.63	ND	0.57	0.28
P09581	Csf1r	Macrophage colony-stimulating factor 1 receptor	11	8	48.61	ND	ND	ND	0.43
P29533	Vcam1	Vascular cell adhesion	12	7	24.93	ND	ND	ND	0.42

dpi Days post-infection, FC fold change, hpi hours post-infection, ND not determined, sEVs serum-derived extracellular vesicle

ISSN: 1756-3305