Fig. 6

Regulatory mechanism of apoptosis induced by ER stress. This figure shows that the classic ER stress pathway induces cell apoptosis. Apaf1, Cytc, Fodrin, PERK, eiF2α, IRE1α, TRAF2, ASK1, and API were coded with apaf1, cycs, sptan1, eif2ak3, eif2s1, ern1, traf2, map3k5, and fos, respectively. Beta-actin and γ-actin were respectively coded with actb and actg1. Calpains included the calpain-1 catalytic subunit and the calpain-2 catalytic subunit, which were coded with capn1 and capn2. PARPs include poly [ADP-ribose] polymerase 2 and poly [ADP-ribose] polymerase 4, which were coded with parp2 and parp4. JNKs include mitogen-activated protein kinase 9 and mitogen-activated protein kinase 10, which were respectively coded with mapk9 and mapk10. IP3Rs include inositol 1,4,5-trisphosphate receptor type 2 and inositol 1,4,5-trisphosphate receptor type 3, which were respectively coded with itpr1, itpr2, and itpr3. The mRNA expression of itpr2, capn1, mc, actg1, actb, parp2, traf2, and fos increased significantly in this study