Fig. 3

SNP analysis of decoquinate-resistant strains developed in the laboratory. A PCA analysis of SNPs in the sequencing samples of developing resistant strains. B, C Venn diagram of the SNPs in the H (B) and XJ (C) strains at increasing drug levels during the development of drug resistance. D Venn diagram of genes containing non-synonymous mutations shared between H-120 mg/kg (DecR_H) and XJ-120 mg/kg (DecR_XJ). E Occurrence and allele frequency of missense mutations in the cytochrome b gene during the development of drug resistance. DecR, Decoquinate resistance; H, Houghton strain; PCA, principal component analysis; SNP single nucleotide polymorphism; XJ, Xinjiang strain