Table 1 All 53 proteins of Ts-ML-EVs recognized by 25 dpi swine serum were identified by LC-MS/MS

A0A0V1BD93

Transmembrane protease serine 9

Prss30

126.2

9.22E+09

A0A0V1APR5

Snake venom 5'-nucleotidase

T01_175

61.9

4.36E+08

A0A0V1BSV1

ADP-ribose pyrophosphatase, mitochondrial

Nudt9

58.9

2.33E+08

A0A0V1C075

Deoxyribonuclease-2-alpha (fragment)

Dnase2

142.9

3.02E+09

A0A0V1AKL7

Metallophos domain-containing protein (fragment)

T01_11872

28.5

6.30E+06

A0A0V1ASF3

ADP-ribose pyrophosphatase, mitochondrial

Nudt9

54.5

1.63E+08

E5RYV9

Transmembrane protease serine 9

Tmprss9

71.6

3.37E+07

A1BQX7

Multi cystatin-like domain protein

mcd-1

45.9

7.45E+07

A0A0V1B2X1

Uncharacterized protein

T01_5772

50.7

6.47E+07

A0A0V1AS64

ADP-ribose pyrophosphatase, mitochondrial

Nudt9

57.2

4.31E+06

A0A0V1AVV5

Peptidase inhibitor R3HDML (fragment)

R3HDML

82

4.09E+07

A0A0V1BXV2

Mothers against decapentaplegic homolog

Mad

284.6

1.04E+08

A0A0V1ASF1

53 kDa excretory/secretory antigen (predicted)

T01_13886

41.2

4.52E+07

A0A0V1BH58

Ubiquitin–protein ligase (predicted)

T01_8770

37.2

9.59E+06

A0A0V1AX39

Fructose-bisphosphate aldolase

T01_11246

43.6

4.08E+06

A0A0V1BT87

2-Phospho-D-glycerate hydro-lyase (Fragment)

enol-1

50.3

2.98E+06

A0A0V1BNJ5

Malate dehydrogenase (fragment)

MDH2

109.1

1.72E+06

A0A0V1C1L0

Uncharacterized protein

T01_11591

36.2

2.06E+07

E5S9D6

Apple domain-containing protein

T01_1244

49.9

1.24E+07

A0A0V1B1S0

Putative nudix hydrolase 6

ndx-6

51

1.31E+07

A0A0V1AYM6

Peptidase S1 domain-containing protein

T01_6497

93.1

7.15E+06

E5RYD6

Peptidase S1 domain-containing protein (predicted)

T01_2202

31.2

1.98E+07

A0A0V1BT34

53 kDa excretory/secretory antigen (predicted)

T01_4139

34

8.55E+06

A0A0V1AZ55

Phosphoenolpyruvate carboxykinase (GTP)

PEPCK

83

5.03E+06

A0A0V1BN13

Sodium/potassium-transporting ATPase subunit beta-1

ATP1B1

303.9

3.92E+06

A0A0V1BXN8

Malic enzyme

Me3

137.3

1.50E+06

A0A0V1BCK0

Mannose-6-phosphate isomerase

T01_7294

484

1.75E+07

A0A0V1BWP3

Cysteinylglycine-S-conjugate dipeptidase

lap3

57.2

1.20E+07

A0A0V1B1P7

DDE_Tnp_1_7 domain-containing protein

T01_8160

51.1

1.93E+06

A0A0V0YZ53

Transmembrane protease serine 2 (fragment)

Tmprss2

10

A0A0V1BW27

Glioma pathogenesis-related protein 1

T01_3621

52.7

7.07E+05

A0A0V1ARS7

ADP-ribose pyrophosphatase, mitochondrial

NUDT9

26.8

5.76E+06

A0A0V1AVL6

Tissue-type plasminogen activator

PLAT

44.2

A0A0V1BP23

Cleavage and polyadenylation specificity factor subunit 2

Cpsf2

125.5

2.89E+06

A0A0V1AUA7

Transmembrane protease serine 9

TMPRSS9

152.1

1.59E+06

A0A0V1BIS9

Serine protease 28

Prss28

34

5.41E+06

E5SLU1

Actin-5C

Act5C

41.8

5.24E+06

A0A0V1BW41

Glutamate dehydrogenase (NAD(P)(+))

GLUD2

115.4

A0A0V1BIH7

SML-4

sml-4

15.7

1.35E+06

A0A0V1BU64

PAN domain protein (predicted)

T01_14583

107.5

A0A0V1BUA3

BAR domain-containing protein (fragment)

T01_4307

47.1

1.08E+07

A0A0V1B2I0

Plasma kallikrein

Klkb1

35.2

8.31E+06

A0A0V1AU45

ATP synthase subunit alpha (fragment)

ATP5A1

61.9

3.63E+06

A0A0V1B0A9

Tetratricopeptide repeat protein 37

TTC37

192.9

4.44E+06

A0A0V1C272

Uncharacterized protein

T01_3299

12.7

5.70E+05

A0A0V1BM94

Uncharacterized protein

T01_10190

13

A0A0V1B8T3

Chymotrypsinogen B (fragment)

CTRB1

33.6

1.14E+06

A0A0V1BVG9

Trans-2-enoyl-CoA reductase, mitochondrial (fragment)

MECR

40.4

6.80E+05

A0A0V1B1B9

3-Ketoacyl-CoA thiolase, mitochondrial (fragment)

ACAA2

78

6.81E+05

A0A0V1BBH0

Secreted from muscle stage larvae 1 (predicted)

T01_15448

32.2

A0A0V1B416

Peregrin

BRPF1

132.4

E5SUQ1

Enteropeptidase

Tmprss15

75.1

A0A0V1BNM9

Non-specific serine/threonine protein kinase

ATR

298.4

5.22E+06