A nanoparticle vaccine displaying the ookinete PSOP25 antigen elicits transmission-blocking antibody response against Plasmodium berghei

Table 2 Transmission-blocking activity of passively transferred antibodies from different immunization groups

Group	Oocyst density mean (range) (n = 30)	TRA^a (%)	Prevalence of infection mean (%) (n = 30)	TBA^b (%)
rPSOP25	67.8 (0–117)	29.4	86.7 (26/30)	10.0
Untagged AP205 + rPSOP25	63.8 (0–125)	33.6	83.3 (25/30)	13.4
VLP-PSOP25	18.8 (0–66)	80.4	63.3 (19/30)	33.4
rPSOP25 + alum	31.2 (0–98)	67.5	73.3 (22/30)	23.4
PBS	96.1 (0–237)		96.7 (29/30)

^aTRA was calculated as (mean oocyst density_PBS−mean oocyst density_{rPSOP25/untagged AP205 + rPSOP25/VLP-PSOP25/rPSOP25 + alum})/mean oocyst density_PBS × 100%
^bTBA was calculated as % prevalence_PBS−% prevalence_{rPSOP25/untagged AP205 + rPSOP25/VLP-PSOP25/rPSOP25 + alum}

ISSN: 1756-3305