Fig. 6

Lentinan mitigated neurite degeneration and increased dendritic spines in the hippocampal CA1 region of Toxoplasma gondii-infected mice. a Representative images of pyramidal neurons in the CA1 region of the hippocampus of control (Con), ConL, Tg and TgL mice (scale bar: 100 μm). b Total neurite length and (c) number of neuritic branches per cell (n = 18–20). d Sum intersection (10–300 μm from soma) per cell (n = 18–20). e Sholl analysis showing the number of intersections at different distances from soma (per 50 μm, 0–300 μm). f–g Representative images (scale bar: 10 μm) and quantification of dendritic spines of neurons in the CA1 region of the hippocampus (n = 50). Con: control group; ConL: Con + Lentinan group; Tg: chronic T. gondii-infected group; TgL: Tg + Lentinan group. Values are mean ± SEM. **P < 0.01, ***P < 0.001