Fig. 7

Lentinan improved the synaptic ultrastructural impairment in the hippocampus of Toxoplasma gondii-infected mice. a The ultrastructure of synapses on the electron micrograph in the hippocampus CA1 region of Con, ConL, Tg, TgL mice (scale bar: 100 nm). b–e Image analysis of the synaptic ultrastructure with software ImageJ (n = 3, 8 images per mouse): b Thickness of postsynaptic density. c Length of active zone. d The synaptic curvature. e Width of the synaptic cleft. f mRNA expression of postsynaptic density 95 (PSD95) in the hippocampus of Con, ConL, Tg, TgL mice (n = 6–8). g mRNA expression of synaptophysin (SYN) in the hippocampus of Con, ConL, Tg, TgL mice (n = 6–8). Con: control group; ConL: Con + Lentinan group; Tg: chronic T. gondii-infected group; TgL: Tg + Lentinan group. SC synaptic cleft, SV synaptic vesicle. Values are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001