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Table 4 Adverse events and adherence to the treatment regimens in the patients*

From: Artemisinin-naphthoquine plus lower-dose primaquine to treat and prevent recurrence of Plasmodium vivax malaria: an open-label randomized and non-inferiority trial

 

ANPQ3 group (N = 177)

CQPQ14 group (N = 130)

P value

Adverse effects

 Dizziness—no. (%; 95% CI)

1 (0.6, 0.01–3.1)

1 (0.8, 0.02–4.2)

1.000

 Nausea—no. (%; 95% CI)

4 (2.3, 0.6–5.7)

2 (1.5, 0.2–5.5)

1.000

 Diarrhoea—no. (%; 95% CI)

1 (0.6, 0.01–3.1)

0 (0, 0–2.8)

1.000

 Haemolysis—no. (%; 95% CI)

0 (0, 0–2.1)

5 (3.9, 1.3–8.8)

0.0130

 Total—no. (%; 95% CI)

6 (3.4, 1.3–7.3)

7 (5.4, 2.2–10.8)*

0.4056

Patient adherence

 Person-days of planned medication

531

1820

 

 Person-days of actual medication

523

1666

 

 Medication percentage (95% CI)

98.5 (97.1–99.2)

91.5 (90.2–92.7)

 < 0.0001

  1. ANPQ3 artemisinin-naphthoquine plus primaquine for 3 days, CQPQ14 chloroquine plus primaquine for 14 days, 95% CI 95% confidence interval
  2. *One patient had more than one adverse event