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Table 2 Number (%) of participants with mfAC number increases from pre-treatment to Day 4 or Month 1 and from Day 4 to Month 1 resulting in mfAC levels in a higher mfAC category

From: Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia

mfAC category

Moxidectin

Ivermectin

Nf

1–5 mfAC

6–10 mfAC

11–20 mfAC

21–40 mfAC

 > 40

Any mfAC increase

Nf

1–5 mfAC

6–10 mfAC

11–20 mfAC

21–40 mfAC

 > 40 mfAC

Any mfAC increase

  

n

%

n

%

n

%

n

%

n

%

n

%

 

N

%

n

%

n

%

n

%

n

%

n

%

PreTx

 

Day 4

       

Day 4

      

0

596

135

22.7

11

1.8

3

0.5

1

0.2

  

150

25.2

289

49

17.0

4

1.4

1

0.3

2

0.7

  

56

19.4

1–5

183

  

16

8.7

13

7.1

3

1.6

4

2.2

36

19.7

96

  

15

15.6

3

3.1

4

4.2

  

22

22.9

6–10

59

    

3

5.1

4

6.8

2

3.4

9

15.3

29

    

2

6.9

2

6.9

3

10.3

7

24.1

11–20

67

      

1

1.5

2

3.0

3

4.5

45

      

5

11.1

2

4.4

7

15.6

21–40

52

        

4

7.7

4

7.7

18

            

Sum

957

135

14.1

27

2.8

19

2.0

9

0.9

12

1.3

202

21.1

477

49

10.3

19

4.0

6

1.3

13

2.7

5

1.0

92

19.3

PreTx

 

Month 1

       

Month 1

      

0

592

113

19.1

5

0.8

2

0.3

1

0.2

  

121

20.4

287

45

15.7

6

2.1

  

1

0.3

  

52

18.1

1–5

181

  

9

5.0

9

5.0

5

2.8

2

1.1

25

13.8

96

  

3

3.1

6

6.3

  

1

1.0

10

10.4

6–10

59

    

4

6.8

3

5.1

1

1.7

8

13.6

29

    

1

3.4

2

6.9

  

3

10.3

11–20

67

      

1

1.5

  

1

1.5

45

      

5

11.1

1

2.2

6

13.3

21–40

52

        

2

3.8

2

3.8

18

            

Sum

951

113

11.9

14

1.5

15

1.6

10

1.1

5

0.5

157

16.5

475

45

9.5

9

1.9

7

1.5

8

1.7

2

0.4

71

14.9

Day 4

 

Month 1

       

Month 1

      

0

533

68

12.8

9

1.7

2

0.4

    

79

14.8

263

37

14.1

4

1.5

      

41

15.6

1–5

237

  

4

1.7

4

1.7

3

1.3

1

0.4

12

5.1

105

  

3

2.9

1

1.0

  

1

1.0

5

4.8

6–10

71

    

2

2.8

3

4.2

  

5

7.0

42

    

2

4.8

    

2

4.8

11–20

72

      

2

2.8

  

2

2.8

34

      

2

5.9

  

2

5.9

21–40

32

        

2

6.3

2

6.3

29

            

Sum

945

68

7.2

13

1.4

8

0.8

8

0.8

3

0.3

100

10.6

473

37

7.8

7

1.5

3

0.6

2

0.4

1

0.2

50

10.6

  1. mfAC: live microfilariae in the anterior chamber; PreTx: pre-treatment; Nf: number of participants with data at relevant follow-up timepoints; % calculated based on Nf
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