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Table 3 Number (%) of participants by mfAC category at Months 6, 12 and 18 by pre-treatment mfAC category and treatment arm

From: Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia

PreTx

Moxidectin

Ivermectin

mfAC

Any mfAC

0 mfAC

1–5 mfAC

6–10 mfAC

11–20 mfAC

21–40 mfAC

 > 40 mfAC

Any mfAC

0 mfAC

1–5 mfAC

6–10 mfAC

11–20 mfAC

21–40 mfAC

 > 40 mfAC

 

N

n

%

n

%

n

%

n

%

n

%

n

%

N

n

%

n

%

n

%

n

%

n

%

n

%

  

Month 6

 

Month 6

0

586

571

97.4

15

2.6

 

0.0

      

287

279

97.2

8

2.8

        

1–5

179

164

91.6

12

6.7

1

0.6

2

1.1

    

95

89

93.7

6

6.3

        

6–10

58

51

87.9

6

10.3

1

1.7

      

29

26

89.7

3

10.3

        

11–20

65

61

93.8

2

3.1

1

1.5

1

1.5

    

45

43

95.6

2

4.4

        

21–40

52

45

86.5

5

9.6

1

1.9

1

1.9

    

18

18

100.0

          

 > 40

16

14

87.5

1

6.3

1

6.3

      

13

10

76.9

1

7.7

  

1

7.7

  

1

7.7

All

956

906

94.8

41

4.3

5

0.5

4

0.4

    

487

465

95.5

20

4.1

  

1

0.2

  

1

0.2

  

Month 12

 

Month 12

0

574

570

99.3

3

0.5

1

0.2

      

281

276

98.2

4

1.4

1

0.4

      

1–5

180

175

97.2

5

2.8

        

93

91

97.8

2

2.2

        

6–10

57

53

93.0

4

7.0

        

28

26

92.9

2

7.1

        

11–20

63

61

96.8

1

1.6

1

1.6

      

43

37

86.0

6

14.0

        

21–40

51

50

98.0

1

2.0

        

18

18

100.0

 

0.0

        

 > 40

16

14

87.5

 

0.0

  

1

6.3

1

6.3

  

13

7

53.8

3

23.1

1

7.7

1

7.7

  

1

7.7

All

941

923

98.1

14

1.5

2

0.2

1

0.1

1

0.1

  

476

455

95.6

17

3.6

2

0.4

1

0.2

  

1

0.2

  

Month 18

 

Month 18

0

449

444

98.9

5

1.1

        

223

220

98.7

2

0.9

1

042

      

1–5

145

143

98.6

2

1.4

        

69

65

94.2

3

4.3

1

1.4

      

6–10

49

48

98.0

1

2.0

        

28

25

89.3

3

10.7

        

11–20

56

55

98.2

  

1

1.8

      

36

35

97.2

1

2.8

        

21–40

46

45

97.8

1

2.2

        

15

15

100.0

 

0.0

        

 > 40

13

13

100.0

          

11

6

54.5

3

27.3

  

1

9.1

  

1

9.1

All

758

748

98.7

9

1.2

1

0.1

      

382

366

95.8

12

3.1

2

0.5

1

0.3

  

1

0.3

  1. mfAC: live microfilariae in the anterior chambers; % calculated based on all participants with data in the specified PreTx mfAC category (N)
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