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Table 5 Number (%) of participants by mfAC category on Day 4 and Month 1 and pre-treatment IoI for participants with mfAC number increases from pre-treatment to Day 4 or Month 1 and from Day 4 to Month 1 resulting in mfAC levels in a higher mfAC category

From: Onchocerca volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia

IoI

Moxidectin

Ivermectin

 

1–5

6–10

11–20

21–40

 > 40

Any increase

 

1–5

6–10

11–20

21–40

 > 40

Any increase

N

n

%

n

%

n

%

n

%

n

%

n

%

N

n

%

n

%

n

%

n

%

n

%

N

%

 

Day 4 mfAC category of participants with mfAC increase from preTx to Day 4

 < 20

279

38

13.62

1

0.36

1

0.36

1

0.36

2

0.72

43

15.41

148

38

13.62

1

0.36

1

0.36

1

0.36

2

0.72

43

15.41

20- < 50

454

68

14.98

13

2.86

7

1.54

2

0.44

2

0.44

92

20.26

181

68

14.98

13

2.86

7

1.54

2

0.44

2

0.44

92

20.26

 ≥ 50

240

29

12.08

13

5.42

11

4.58

6

2.5

8

3.33

67

27.92

161

29

12.08

13

5.42

11

4.58

6

2.5

8

3.33

67

27.92

All

973

135

13.87

27

2.77

19

1.95

9

0.92

12

1.23

202

20.76

490

135

13.87

27

2.77

19

1.95

9

0.92

12

1.23

202

20.76

 

Month 1 mfAC category for participants with mfAC increase from preTx to Month 1

 < 20

278

24

8.63

 

0

1

0.36

 

0

 

0

25

8.99

148

10

6.76

1

0.68

2

1.35

2

1.35

 

0

15

10.14

20- < 50

450

56

12.44

8

1.78

8

1.78

1

0.22

 

0

73

16.22

181

16

8.84

 

0

1

0.55

 

0

 

0

17

9.39

 ≥ 50

239

33

13.81

6

2.51

6

2.51

9

3.77

5

2.09

59

24.69

159

19

11.95

8

5.03

4

2.52

6

3.77

2

1.26

39

24.53

All

967

113

11.69

14

1.45

15

1.55

10

1.03

5

0.52

157

16.24

488

45

9.22

9

1.84

7

1.43

8

1.64

2

0.41

71

14.55

 

Month 1 mfAC category for participants with mfAC increase from Day 4 to Month 1

 < 20

278

13

4.68

 

0

1

0.36

 

0

 

0

14

5.04

148

9

6.08

1

0.68

1

0.68

1

0.68

 

0

12

8.11

20- < 50

450

32

7.11

9

2

3

0.67

1

0.22

 

0

45

10.00

181

20

11.05

 

0

1

0.55

 

0

 

0

21

11.60

 ≥ 50

239

23

9.62

4

1.67

4

1.67

7

2.93

3

1.26

41

17.15

159

8

5.03

6

3.77

1

0.63

1

0.63

1

0.63

17

10.69

All

967

68

7.03

13

1.34

8

0.83

8

0.83

3

0.31

100

10.34

488

37

7.58

7

1.43

3

0.61

2

0.41

1

0.2

50

10.25

  1. mfAC: live microfilariae in the anterior chamber; PreTx: pre-treatment; N: number of participants with mfAC data at Day 4 and Month 1, respectively; % calculated based on total number of participants with mfAC data on Day 4 or Month 1 within each IoI category
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