Fig. 4

Biological processes for protein families abundant in small extracellular vesicles (EVs) and EV-depleted excretory/secretory products (ESPs) of Haemonchus contortus. A Sankey diagram showing the involved biological processes of protein families unique or abundant in the small (EVs) of H. contortus. B Sankey diagram showing the involved biological processes of protein families unique or abundant in the EV-depleted ESPs of H. contortus. Protein families are listed above the red dashed line, with biological processes linked. Diagrams are drawn in R environment using a sankeywheel package (version 0.1.0). PIs protease inhibitors, E/S proteins, excretory/secretory proteins, DUFs domain of unknown function, LBPs lipid-binding proteins, CBPs calcium-binding proteins, HSPs heat shock proteins, Rhos small GTPases, TTRs transthyretin-like family, IgLs Ig-like superfamily