Table 1 Comparison of important proteins identified in small EVs and EV-depleted ESPs

Protease

71

47

57

 Cysteine protease

27

4

16

 Aminopeptidase

2

2

11

 Serine protease

7

1

3

 Metallopeptidase

6

11

4

 Aspartyl protease

8

6

11

 Other protease

21

23

12

Protease inhibitor

4

10

7

 Serine protease inhibitor

3

9

4

 Cysteine protease inhibitor

1

1

2

 Aspartyl protease inhibitor

0

0

1

Excretory/secretory protein

12

75

16

 CRISP/SCP/CAP family

9

59

9

 Secreted protein

3

16

7

Protein of unknown function

19

57

23

Lectin

3

6

8

 C-type Lectin

0

2

0

 Galectin

3

3

6

 Other lectin

0

1

2

Lipid-binding protein

3

8

13

 Nematode fatty acid retinoid-binding protein

0

2

3

 Fatty-acid-binding protein

0

2

3

 Saposin

1

2

4

 Annexin

1

0

1

 START domain-containing protein

0

2

1

 Glycolipid transfer protein

1

0

0

 Vitellogenin domain-containing protein

0

0

1

Calcium ion-binding protein

6

9

17

 EF-hand domain protein

1

4

6

 Other calcium ion-binding protein

5

5

11

Heat shock protein

4

2

10

Small GTPase family

18

4

3

Transthyretin-like family

6

8

17

von Willebrand factor

1

6

1

Ig-like superfamily

2

15

5

DOMON domain-containing protein

1

5

1

Globin

1

2

8

Collagen

7

6

1

Fibrinogen

0

4

1