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Table 4 Autoantibody prevalence in serum from patients with systemic lupus erythematosus in relation to anti-Toxoplasma gondii antibodies immunoglobulin G

From: Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus

Autoantibodiesa

All patients (n = 863)

ATxA-IgG+ SLE patients (n = 144)

ATxA-IgG− SLE patients (n = 719)

P valueb

ANA positive, n (%)

669 (88.5%)

107 (88.4%)

562 (88.5%)

0.981

ANUA positive, n (%)

417 (54.4%)

76 (62.3%)

341 (53.0%)

0.057

Anti-rRNP positive, n (%)

246 (37.3%)

51 (47.7%)

195 (35.3%)

0.016*

Anti-Ro/SSA positive, n (%)

349 (46.7%)

59 (49.6%)

290 (46.2%)

0.495

Anti-La/SSB positive, n (%)

87 (11.6%)

14 (15.9%)

73 (11.6%)

0.960

Anti-dsDNA positive, n (%)

518 (65.4%)

97 (75.2%)

421 (63.5%)

0.011*

Anti-cmDNA positive, n (%)

33 (5.4%)

13 (13.5%)

20 (3.9%)

0.00011*

Anti-Sm positive, n (%)

142 (19.1%)

29 (19.1%)

113 (18.1%)

0.113

Anti-Scl-70, n (%)

22 (4.4%)

7 (9.5%)

15 (3.5%)

0.021*

Rheumatoid factor (RF), n (%)

93 (12.9%)

22 (19.0%)

71 (11.8%)

0.035*

Anti-CL, n (%)

134 (19.2%)

36 (32.4%)

98 (16.7%)

0.00011*

Anti-B2GPI, n (%)

78 (11.1%)

18 (16.8%)

60 (10.1%)

0.041*

  1. ATxA IgG+, Anti-Toxoplasma gondii antibodies immunoglobulin G-positive, ATxA IgG− anti-Toxoplasma gondii antibodies immunoglobulin G-negative, SLE systemic lupus erythematosus
  2. *Statistically significant
  3. aANA, Anti-nuclear antigen; ANUA, anti-nucleosome antigen; rRNP, ribosomal RNA protein, Ro/SSA, Ro/Sjögren’s syndrome A; La/SSB, La/Sjögren’s syndrome B; dsDNA, double-stranded DNA; cmDNA, cell membrane DNA; Sm, Smith; Scl-70, scleroderma-70; CL, cardiolipin; B2GPI, beta2-glycoprotein-I
  4. bP value: adjusted for age(years) and sex