Table 1 Overview of study design in five studies evaluating the efficacy of treatment with moxidectin against the JYD-34 isolate of Dirofilaria immitis
Study no.1 | Calendar year of execution | Group | No. of dogs per group | Treatment2 | Dose (µg/kg) | Day(s) of treatment3 | Days post infection of necropsy | No. of dogs with worms | Worm count range | Worm count geometric mean | % Efficacy | P-value4 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2013 | A | 4 | Control | N/A5 | N/A | 148 | 4 | 30–37 | 32.9 | N/A | N/A |
B | 4 | Moxidectin | 30 | 0, 30, 60 | 148 | 2 | 0–3 | 0.7 | 97.9 | 0.0030 | ||
C | 4 | Moxidectin | 50 | 0, 30, 60 | 148 | 1 | 0–2 | 0.3 | 99.0 | 0.0009 | ||
D | 4 | Moxidectin | 100 | 0 | 148 | 4 | 1–9 | 2.9 | 91.1 | 0.0133 | ||
2 | 2017 | A | 5 | Control | N/A | N/A | 180 | 5 | 8–29 | 15.2 | N/A | N/A |
B | 4 | Moxidectin | 9 | 0, 30, 60, 90, 120 | 180 | 1 | 0–1 | 0.2 | 98.8 | < 0.0001 | ||
3 | 2017 | A | 5 | Control | N/A | N/A | 176 | 5 | 32–39 | 34.5 | N/A | N/A |
B | 4 | Moxidectin | 9 | 0, 31, 61, 90, 119 | 176 | 4 | 1–6 | 2.0 | 94.1 | 0.0025 | ||
4 | 2017 | A | 5 | Control | N/A | N/A | 181 | 5 | 23–51 | 35.9 | N/A | N/A |
B | 4 | Moxidectin | 6 | 0, 31, 60, 90, 119 | 181 | 4 | 1–14 | 6.0 | 83.3 | 0.0277 | ||
5 | 2018 | A | 5 | Control | N/A | N/A | 180 | 5 | 29–48 | 38.0 | N/A | N/A |
B | 4 | Moxidectin | 6 | 0, 31, 60, 90, 1196 | 180 | 4 | 1–6 | 3.7 | 90.2 | 0.0021 |