Fig. 2

The potency of four active test compounds (MMV1794214, MMV1794206, MMV1577463 and MMV027339) against exsheathed third-stage larvae (xL3s) of Haemonchus contortus, the potency of two active test compounds (MMV1794214 and MMV1794206) on adult females of H. contortus, and the potency of one active test compound (MMV1794206) on young adults of Caenorhabditis elegans, with reference to monepantel and/or moxidectin (positive controls). Each curve shows (A) the inhibition of H. contortus larval motility at 90 h, (B) the inhibition of H. contortus larval development at 7 days, (C) the in vitro motility inhibition (%) of H. contortus adult females over a period of 24 h (motility scores assessed at 3-, 6-, 12- and 24 h time points; cf. Taki et al. [59]) and (D) the reduction of C. elegans motility at 40 h. Data points represent either one (C) or three (A, B and D) experiments conducted in triplicate; the mean ± standard deviation (SD, C) or standard error the mean (SEM, A, B and D). Statistical significance was evaluated with reference to a negative control (C); **** denotes P ≤ 0.0001