Table 1 Results of the primary screen of the Global Health Priority Box and four positive-control compounds (monepantel, moxidectin, monepantel/abamectin and M-666) against exsheathed third-stage larvae (xL3s) of Haemonchus contortus and young adults of Caenorhabditis elegans
Compound | H. contortus | C. elegans | ||
|---|---|---|---|---|
Reduction in larval motility; % (SEM)a | Larval development inhibition; %b | Abnormal phenotypeb,c | Reduction in young adult motility; % (SEM)d | |
MMV1577458 | 115 (6) | 100 | Cur | 115 (7) |
MMV688934 | 115 (6) | 100 | Str | 8.28 (16.0) |
MMV002519 | 98.7 (10.7) | 100 | Str | − 10.8 (14.4) |
MMV1794214 | 86.8 (16.8) | 0 | – | 25.6 (0.1) |
MMV1577463 | 82.7 (0.8) | 0 | – | − 6.1 (13.5) |
MMV027339 | 73.6 (15.5) | 0 | – | − 0.9 (16.3) |
MMV1794206 | 72.6 (32.5) | 100 | Cur | 115 (7) |
MMV1577454 | 60.0 (34.9) | 100 | Str | 98.5 (4.1) |
MMV1633829 | 59.8 (3.2) | 90 | – | 98.1 (22.9) |
MMV1578924 | 57.9 (29.8) | 90 | – | 99.3 (7.2) |
MMV1634081 | 57.0 (4.1) | 95 | Str | − 9.8 (2.6) |
MMV1577467 | 51.2 (15.8) | 100 | Str | 21.1 (1.6) |
MMV1633828 | 34.7 (5.1) | 100 | – | 108 (2) |
MMV672931 | 22.0 (16.3) | 95 | – | 104 (12) |
MMV1633823 | 6.98 (35.7) | 90 | – | 68.0 (11.7) |
MMV002231 | − 27.4 (30.1) | 100 | Cur | 101 (19) |
Monepantel | 92.2 (5.4) | 100 | Coi | 68.6 (4.4) |
Moxidectin | 54.7 (13) | 100 | – | 100 (3) |
Monepantel/abamectin | 107 (5) | 100 | Coi | 92.1 (4.5) |
M-666 | 115 (3) | 100 | Cur | 115 (3) |