Fig. 7
From: Construction of luciferase-expressing Neospora caninum and drug screening
Therapeutic effect of TAK-632 on N. caninum infection in mice. BALB/c mice were infected with a dose of 1 × 107 Nc1 tachyzoites by intraperitoneal injection. After 24 h of infection, mice were orally administered corn oil or TAK-632 once daily for 10 consecutive days at the indicated concentrations (six mice per group). Mice were observed for 30 days. A Survival curves. B Body weight (%). The weight was measured every 2 days. C Detection of parasite burden in the brains of surviving mice by qPCR. Results are shown as mean ± SD. Survival curves were plotted with GraphPad Prism using the log-rank (Mantel–Cox) test (San Diego, CA). Body weight and parasite burden in the brain were analyzed by t-test in GraphPad Prism (San Diego, CA, USA). **** P<  0.0001; ***P < 0.001; **P < 0.01; *P < 0.05