New benzimidazole derivative compounds with in vitro fasciolicidal properties

Parasites & Vectors

Table 4 Ovicidal activity of BZDs, CLR, TCBZ, ABZSO, and OXF at a dose of 5 µM against Fasciola hepatica, susceptible and resistant to ABZ

Compound identification	% Ovicidal activity susceptible isolate	% Ovicidal activity resistant isolate
BZD31	74.59 ± 05.72	53.24 ± 20.94
BZD46	71.21 ± 09.91	11.06 ± 05.30
BZD56	89.22 ± 02.88	12.39 ± 03.71
BZD59	73.51 ± 08.88	06.28 ± 05.20
OXF	98.48 ± 00.37	03.41 ± 02.08
ABZSO	99.37 ± 00.34	26.12 ± 11.87
TCBZ	01.60 ± 01.44	–
CLR	00.70 ± 04.50	–
ABZ (DD)	98.55 ± 00.41	36.46 ± 02.36

Values are represented as a mean ± standard error of the mean (SEM). All experiments were done by triplicate two different days
ABZ, albendazole; ABZSO, albendazole sulfoxide; CLR, clorsulon; DD, discriminant dose to detect ABZ resistance; OFX, oxfendazole; TCBZ, triclabendazole

ISSN: 1756-3305