Advances in the study of the interaction between schistosome infections and the host's intestinal microorganisms

Hong, Ao; Umar, Abdulrahim; Chen, Hao; Yu, Zheng; Huang, Jing

doi:10.1186/s13071-024-06245-1

Parasites & Vectors

Table 1 Intestinal commensal bacteria and their association with schistosomiasis

From: Advances in the study of the interaction between schistosome infections and the host's intestinal microorganisms

Phylum	Family/genus/species	Host	Observations	References
Proteobacteria	Comamonas and Psychrobacter	Adults	Negatively correlated with parasite burden	[18]
	Lachnospiraceae_NK4A136	BALB/c mice	Negatively correlated with parasite burden	[17]
	Ruminiclostridium	BALB/c mice	Negatively correlated with parasite burden	[17]
	Methylophilus	Adults	An inflammatory response to acute schistosomiasis, positively correlated with parasite burden	[18]
	Salmonella typhimurium (ATCC14028)	Children	Reduced the number of adult schistosomal worms and eggs and relieved symptoms of schistosomiasis	[103]
Firmicutes	Bacillus amyloliquefaciens	BALB/c mice	Modulated disease severity	[86]
	Bacillus subtilis	BALB/c mice	Modulated disease severity	[87]
	Butyricimonas and Veillonella	Adults	Negatively correlated with parasite burden	[18]
	Clostridium	Adults	Correlated with total cholesterol levels, negatively correlated with parasite burden	[18]
	Faecalibacterium	Adults	Negatively correlated with liver damage in patients with S. japonicum infection	[104]
	Lactobacillaceae	Microtus fortis	A positive role in the natural resistance to schistosome infection, positively correlated with parasite burden in Microtus fortis	[9]
	Megamonas	Adults	A biomarker for diagnosis which helped to discriminate different stages of S. japonicum infection	[105]
	Muribaculaceae	Microtus fortis	A negative role in the natural resistance to schistosome infection, negatively correlated with parasite burden in Microtus fortis	[9]
	Roseburia	C57BL/6 mice	Positively correlated with S. mansoni infection burden	[66]
	Ruminococcus	C57BL/6 mice	Negatively correlated with infection burden	[66]
	Shuttleworthia	C57BL/6 mice	Negatively correlated with S. mansoni infection burden	[66]
	Turicibacter	Adults	An inflammatory response to acute schistosomiasis, positively correlated with parasite burden	[18]
Bacteroidetes	Alistipes	BALB/c mice	Depleted in Salmonella-infected mice, led to the destruction of the intestinal barrier	[31]
	Bacteroides	Adults	Activated an infectious response in the intestine, and they were significantly more abundant in a mouse model of S. mansoni infection, displayed a significant correlation with the level of hepatic granulomas	[18, 31]
	Prevotella	Adults and children	A biomarker for diagnosis which helped to discriminate different stages of S. japonicum and S. haematobium infection	[66, 104]
	Sphingobacterium	Adults	Identified as a marker in urogenital schistosomiasis	[106]
Fusobacteriota	Fusicatenibacter	Adults	A biomarker for diagnosis which helped to discriminate different stages of S. japonicum infection	[105]
Veillonellaceae	Akkermansia muciniphila	C57BL/6 and BALB/c mice	Positively associated with S. mansoni infection	[8, 20]
Saccharibacteria (TM7)	Unclassified	Adults	A novel biomarker associated with S. japonicum infection	[18]
Unclassified	Subdoligranulum	Adults	A biomarker for diagnosis which helped to discriminate different stages of S. japonicum infection	[105]

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ISSN: 1756-3305

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