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Volume 10 Supplement 2

Proceedings of the 15th American Heartworm Society Triennial Symposium 2016

Research

Publication of this supplement was funded by the American Heartworm Society. The articles have undergone the journal's standard peer review process for supplements. The Supplement Editor declares that they have no competing interests.

New Orleans, LA, USASeptember 11-13, 2016

Edited by Patricia A. Payne

  1. Several reports have confirmed that macrocyclic lactone-resistant isolates of Dirofilaria immitis are circulating in the United States; however, the prevalence and potential impact of drug resistance is unknown. ...

    Authors: Mary J. Maclean, Molly D. Savadelis, Ruby Coates, Michael T. Dzimianski, Corey Jones, Cynthia Benbow, Bobby E. Storey, Ray M. Kaplan, Andrew R. Moorhead and Adrian J. Wolstenholme

    Citation: Parasites & Vectors 2017 10(Suppl 2):480

    Content type: Research

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  2. Macrocyclic lactone (ML) anthelmintics are used for chemoprophylaxis for heartworm infection in dogs and cats. Cases of dogs becoming infected with heartworms, despite apparent compliance to recommended chemop...

    Authors: Catherine Bourguinat, Francois Lefebvre, Johanna Sandoval, Brenda Bondesen, Yovany Moreno and Roger K. Prichard

    Citation: Parasites & Vectors 2017 10(Suppl 2):494

    Content type: Research

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  3. For dogs and cats, chemoprophylaxis with macrocyclic lactone (ML) preventives for heartworm disease is widely used in the United States and other countries. Since 2005, cases of loss of efficacy (LOE) of heart...

    Authors: Catherine Bourguinat, Kathy Keller, Jianguo Xia, Pierre Lepage, Tom L. McTier, Debra J. Woods and Roger K. Prichard

    Citation: Parasites & Vectors 2017 10(Suppl 2):504

    Content type: Research

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  4. Monthly topical and sustained-release injectable formulations of moxidectin are currently marketed; however, an oral formulation, while approved at a dose of 3 μg/kg, is not currently marketed in the United St...

    Authors: Tom L. McTier, Robert H. Six, Aleah Pullins, Sara Chapin, John W. McCall, Douglas Rugg, Steven J. Maeder and Debra J. Woods

    Citation: Parasites & Vectors 2017 10(Suppl 2):482

    Content type: Research

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  5. Emerging resistance of heartworms (Dirofilaria immitis) to macrocyclic lactone (ML) preventives is an increasing concern for veterinarians, pet owners and animal health companies that supply heartworm preventives...

    Authors: Tom L. McTier, Aleah Pullins, Gregory A. Inskeep, Genevieve Gagnon, Huihao Fan, Adam Schoell, Tara Bidgood, Joyce Login and Patrick Meeus

    Citation: Parasites & Vectors 2017 10(Suppl 2):485

    Content type: Research

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  6. In a previous study, it was demonstrated that ProHeart® 6 (PH6) (moxidectin, Zoetis) provided only about 20% efficacy in a small six-dog study against a macrocyclic lactone –resistant Dirofilaria immitis isolate ...

    Authors: Dwight D. Bowman, Tom L. McTier, Eric L. Adams, Sean P. Mahabir, Joyce A. Login, Tara Bidgood and Debra J. Woods

    Citation: Parasites & Vectors 2017 10(Suppl 2):502

    Content type: Research

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  7. Prior work has shown that the levels of moxidectin in dogs treated with Advantage Multi® for Dogs (Bayer Animal Health) remain at a high plasma concentration for the full month after application. The objective...

    Authors: Dwight D. Bowman, Cameon M. Ohmes, Joseph A. Hostetler, Daniel J. Keil, Terry L. Settje and Samuel D. Charles

    Citation: Parasites & Vectors 2017 10(Suppl 2):478

    Content type: Research

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  8. This study assessed the influence of a topical ectoparasiticide (dinotefuran-permethrin-pyriproxyfen, DPP, Vectra® 3D, Ceva Animal Health) combined with a macrocyclic lactone (milbemycin oxime, MBO, Intercepto...

    Authors: John W. McCall, Marie Varloud, Elizabeth Hodgkins, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, James Carmichael, Ben Carson and Justin Carter

    Citation: Parasites & Vectors 2017 10(Suppl 2):525

    Content type: Research

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  9. This study assessed the influence of a topical ectoparasiticide (dinotefuran-permethrin-pyriproxyfen, DPP, Vectra®3D, Ceva Animal Health) on the acquisition of heartworm microfilariae by mosquitoes exposed to ...

    Authors: John W. McCall, Elizabeth Hodgkins, Marie Varloud, Abdelmoneim Mansour and Utami DiCosty

    Citation: Parasites & Vectors 2017 10(Suppl 2):511

    Content type: Research

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  10. Initial studies of heartworm preventive drugs all yielded an observed efficacy of 100% with a single dose, and based on these data the US Food and Drug Administration (FDA) required all products to meet this s...

    Authors: Anand N. Vidyashankar, Pablo D. Jimenez Castro and Ray M. Kaplan

    Citation: Parasites & Vectors 2017 10(Suppl 2):516

    Content type: Research

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  11. The emergence of macrocyclic lactone resistance in canine heartworm poses a substantial threat to what is currently the only effective, FDA-approved available method of prevention. Further study of the biotype...

    Authors: Andrew R. Moorhead, Christopher C. Evans and Ray M. Kaplan

    Citation: Parasites & Vectors 2017 10(Suppl 2):479

    Content type: Research

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  12. Antigen testing is routinely used to diagnose canine Dirofilaria immitis infections. Immune complex dissociation (ICD) methods, which were employed in the original heartworm antigen tests to release antigen that ...

    Authors: Melissa J. Beall, Andrea Arguello-Marin, Jan Drexel, Jiayou Liu, Ramaswamy Chandrashekar and A. Rick Alleman

    Citation: Parasites & Vectors 2017 10(Suppl 2):481

    Content type: Research

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  13. The diagnosis and management of canine heartworm disease is a growing concern for shelter veterinarians. Although the accuracy of commercial antigen test kits has been widely studied, recent reports have renew...

    Authors: Brian A. DiGangi, Carly Dworkin, Jason W. Stull, Jeanette O’Quin, Morgan Elser, Antoinette E. Marsh, Lesli Groshong, Wendy Wolfson, Brandy Duhon, Katie Broaddus, Elise N. Gingrich, Emily Swiniarski and Elizabeth A. Berliner

    Citation: Parasites & Vectors 2017 10(Suppl 2):483

    Content type: Research

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  14. Heartworm antigen testing is considered sensitive and specific. Currently available tests are reported as detecting a glycoprotein found predominantly in the reproductive tract of the female worm and can reach...

    Authors: Luigi Venco, Simone Manzocchi, Marco Genchi and Laura H. Kramer

    Citation: Parasites & Vectors 2017 10(Suppl 2):476

    Content type: Research

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  15. To evaluate whether heated serum allows for earlier detection of Dirofilaria immitis antigen, dogs with experimental D. immitis infections underwent weekly blood sampling to compare antigen results using both hea...

    Authors: James Carmichael, Scott McCall, Utami DiCosty, Abdelmoneim Mansour and Linda Roycroft

    Citation: Parasites & Vectors 2017 10(Suppl 2):486

    Content type: Research

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  16. Dirofilaria immitis is a worldwide parasite that is endemic in many parts of the United States. There are many commercial assays available for the detection of D. immitis antigen, one ...

    Authors: Lindsay A. Starkey, Joy V. Bowles, Mark E. Payton and Byron L. Blagburn

    Citation: Parasites & Vectors 2017 10(Suppl 2):475

    Content type: Research

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  17. In heartworm disease, several biomarkers of cardiopulmonary injury and inflammatory activity have been studied during the recent years. D-dimer is a fibrin degradation product present after a clot is degraded,...

    Authors: Elena Carretón, Rodrigo Morchón and José Alberto Montoya-Alonso

    Citation: Parasites & Vectors 2017 10(Suppl 2):534

    Content type: Review

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  18. Canine heartworm infection is characterized by pulmonary endarteritis and pulmonary hypertension (PH). The aim of the present study was to evaluate the relationship between PH with the concentrations of differ...

    Authors: Elena Carretón, José Joaquín Cerón, Silvia Martínez-Subiela, Asta Tvarijonaviciute, Alicia Caro-Vadillo and José Alberto Montoya-Alonso

    Citation: Parasites & Vectors 2017 10(Suppl 2):477

    Content type: Research

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  19. Heartworm disease in dogs is a life-threatening parasitic disease. Although adulticide treatment with melarsomine has been proven to be the most effective, complications associated with adulticide treatment ar...

    Authors: Won-Kyoung Yoon, Ye-Won Kim, Sang-I L Suh, Ran Choi, Seung-Gon Lee and Changbaig Hyun

    Citation: Parasites & Vectors 2017 10(Suppl 2):535

    Content type: Research

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  20. Dirofilaria immitis infection occurs in dogs and cats, both of which species are clinically affected by mature adult infections. Cats are uniquely affected by immature-adult infections...

    Authors: Randolph L. Winter, A. Ray Dillon, Russell C. Cattley, Byron L. Blagburn, D. Michael Tillson, Calvin M. Johnson, William R. Brawner, Elizabeth G. Welles and Sharon Barney

    Citation: Parasites & Vectors 2017 10(Suppl 2):492

    Content type: Research

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  21. A controlled, blind research study was conducted to define the initial inflammatory response and lung damage associated with the death of immature adult Dirofilaria immitis in cats as compared with cats developin...

    Authors: A. Ray Dillon, Byron L. Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders and Sharron Barney

    Citation: Parasites & Vectors 2017 10(Suppl 2):514

    Content type: Research

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  22. Heartworm-associated respiratory disease (HARD) in cats is induced by the arrival and death of immature adult Dirofilaria immitis in the pulmonary system and is indistinguishable from mature adult heartworm infec...

    Authors: A. Ray Dillon, Bryon L. Blagburn, Michael Tillson, William Brawner, Betsy Welles, Calvin Johnson, Russell Cattley, Pat Rynders and Sharron Barney

    Citation: Parasites & Vectors 2017 10(Suppl 2):533

    Content type: Research

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