Volume 10 Supplement 2

Proceedings of the 15th American Heartworm Society Triennial Symposium 2016


Publication of this supplement was funded by the American Heartworm Society. The articles have undergone the journal's standard peer review process for supplements. The Supplement Editor declares that they have no competing interests.

New Orleans, LA, USA

September 11-13, 2016

Edited by Patricia A. Payne

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  1. Research

    Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones?

    Several reports have confirmed that macrocyclic lactone-resistant isolates of Dirofilaria immitis are circulating in the United States; however, the prevalence and potential impact of drug resistance is unknown. ...

    Mary J. Maclean, Molly D. Savadelis, Ruby Coates, Michael T. Dzimianski, Corey Jones, Cynthia Benbow, Bobby E. Storey, Ray M. Kaplan, Andrew R. Moorhead and Adrian J. Wolstenholme

    Parasites & Vectors 2017 10(Suppl 2):480

    Published on: 9 November 2017

  2. Research

    Dirofilaria immitis JYD-34 isolate: whole genome analysis

    Macrocyclic lactone (ML) anthelmintics are used for chemoprophylaxis for heartworm infection in dogs and cats. Cases of dogs becoming infected with heartworms, despite apparent compliance to recommended chemop...

    Catherine Bourguinat, Francois Lefebvre, Johanna Sandoval, Brenda Bondesen, Yovany Moreno and Roger K. Prichard

    Parasites & Vectors 2017 10(Suppl 2):494

    Published on: 9 November 2017

  3. Research

    Genetic profiles of ten Dirofilaria immitis isolates susceptible or resistant to macrocyclic lactone heartworm preventives

    For dogs and cats, chemoprophylaxis with macrocyclic lactone (ML) preventives for heartworm disease is widely used in the United States and other countries. Since 2005, cases of loss of efficacy (LOE) of heart...

    Catherine Bourguinat, Kathy Keller, Jianguo Xia, Pierre Lepage, Tom L. McTier, Debra J. Woods and Roger K. Prichard

    Parasites & Vectors 2017 10(Suppl 2):504

    Published on: 9 November 2017

  4. Research

    Efficacy of oral moxidectin against susceptible and resistant isolates of Dirofilaria immitis in dogs

    Monthly topical and sustained-release injectable formulations of moxidectin are currently marketed; however, an oral formulation, while approved at a dose of 3 μg/kg, is not currently marketed in the United St...

    Tom L. McTier, Robert H. Six, Aleah Pullins, Sara Chapin, John W. McCall, Douglas Rugg, Steven J. Maeder and Debra J. Woods

    Parasites & Vectors 2017 10(Suppl 2):482

    Published on: 9 November 2017

  5. Research

    Microfilarial reduction following ProHeart® 6 and ProHeart® SR-12 treatment in dogs experimentally inoculated with a resistant isolate of Dirofilaria immitis

    Emerging resistance of heartworms (Dirofilaria immitis) to macrocyclic lactone (ML) preventives is an increasing concern for veterinarians, pet owners and animal health companies that supply heartworm preventives...

    Tom L. McTier, Aleah Pullins, Gregory A. Inskeep, Genevieve Gagnon, Huihao Fan, Adam Schoell, Tara Bidgood, Joyce Login and Patrick Meeus

    Parasites & Vectors 2017 10(Suppl 2):485

    Published on: 9 November 2017

  6. Research

    Evaluation of the efficacy of ProHeart® 6 (moxidectin) against a resistant isolate of Dirofilaria immitis (JYD-34) in dogs

    In a previous study, it was demonstrated that ProHeart® 6 (PH6) (moxidectin, Zoetis) provided only about 20% efficacy in a small six-dog study against a macrocyclic lactone –resistant Dirofilaria immitis isolate ...

    Dwight D. Bowman, Tom L. McTier, Eric L. Adams, Sean P. Mahabir, Joyce A. Login, Tara Bidgood and Debra J. Woods

    Parasites & Vectors 2017 10(Suppl 2):502

    Published on: 9 November 2017

  7. Research

    Efficacy of 10% imidacloprid + 2.5% moxidectin topical solution (Advantage Multi® for Dogs) for the prevention of heartworm disease and infection all month long

    Prior work has shown that the levels of moxidectin in dogs treated with Advantage Multi® for Dogs (Bayer Animal Health) remain at a high plasma concentration for the full month after application. The objective...

    Dwight D. Bowman, Cameon M. Ohmes, Joseph A. Hostetler, Daniel J. Keil, Terry L. Settje and Samuel D. Charles

    Parasites & Vectors 2017 10(Suppl 2):478

    Published on: 9 November 2017

  8. Research

    Shifting the paradigm in Dirofilaria immitis prevention: blocking transmission from mosquitoes to dogs using repellents/insecticides and macrocyclic lactone prevention as part of a multimodal approach

    This study assessed the influence of a topical ectoparasiticide (dinotefuran-permethrin-pyriproxyfen, DPP, Vectra® 3D, Ceva Animal Health) combined with a macrocyclic lactone (milbemycin oxime, MBO, Intercepto...

    John W. McCall, Marie Varloud, Elizabeth Hodgkins, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, James Carmichael, Ben Carson and Justin Carter

    Parasites & Vectors 2017 10(Suppl 2):525

    Published on: 9 November 2017

  9. Research

    Blocking the transmission of heartworm (Dirofilaria immitis) to mosquitoes (Aedes aegypti) by weekly exposure for one month to microfilaremic dogs treated once topically with dinotefuran-permethrin-pyriproxyfen

    This study assessed the influence of a topical ectoparasiticide (dinotefuran-permethrin-pyriproxyfen, DPP, Vectra®3D, Ceva Animal Health) on the acquisition of heartworm microfilariae by mosquitoes exposed to ...

    John W. McCall, Elizabeth Hodgkins, Marie Varloud, Abdelmoneim Mansour and Utami DiCosty

    Parasites & Vectors 2017 10(Suppl 2):511

    Published on: 9 November 2017

  10. Research

    Validation of immune complex dissociation methods for use with heartworm antigen tests

    Antigen testing is routinely used to diagnose canine Dirofilaria immitis infections. Immune complex dissociation (ICD) methods, which were employed in the original heartworm antigen tests to release antigen that ...

    Melissa J. Beall, Andrea Arguello-Marin, Jan Drexel, Jiayou Liu, Ramaswamy Chandrashekar and A. Rick Alleman

    Parasites & Vectors 2017 10(Suppl 2):481

    Published on: 9 November 2017

  11. Research

    Impact of heat treatment on Dirofilaria immitis antigen detection in shelter dogs

    The diagnosis and management of canine heartworm disease is a growing concern for shelter veterinarians. Although the accuracy of commercial antigen test kits has been widely studied, recent reports have renew...

    Brian A. DiGangi, Carly Dworkin, Jason W. Stull, Jeanette O’Quin, Morgan Elser, Antoinette E. Marsh, Lesli Groshong, Wendy Wolfson, Brandy Duhon, Katie Broaddus, Elise N. Gingrich, Emily Swiniarski and Elizabeth A. Berliner

    Parasites & Vectors 2017 10(Suppl 2):483

    Published on: 9 November 2017

  12. Research

    Heat treatment and false-positive heartworm antigen testing in ex vivo parasites and dogs naturally infected by Dirofilaria repens and Angiostrongylus vasorum

    Heartworm antigen testing is considered sensitive and specific. Currently available tests are reported as detecting a glycoprotein found predominantly in the reproductive tract of the female worm and can reach...

    Luigi Venco, Simone Manzocchi, Marco Genchi and Laura H. Kramer

    Parasites & Vectors 2017 10(Suppl 2):476

    Published on: 9 November 2017

  13. Research

    Evaluation of Dirofilaria immitis antigen detection comparing heated and unheated serum in dogs with experimental heartworm infections

    To evaluate whether heated serum allows for earlier detection of Dirofilaria immitis antigen, dogs with experimental D. immitis infections underwent weekly blood sampling to compare antigen results using both hea...

    James Carmichael, Scott McCall, Utami DiCosty, Abdelmoneim Mansour and Linda Roycroft

    Parasites & Vectors 2017 10(Suppl 2):486

    Published on: 9 November 2017

  14. Review

    Cardiopulmonary and inflammatory biomarkers in heartworm disease

    In heartworm disease, several biomarkers of cardiopulmonary injury and inflammatory activity have been studied during the recent years. D-dimer is a fibrin degradation product present after a clot is degraded,...

    Elena Carretón, Rodrigo Morchón and José Alberto Montoya-Alonso

    Parasites & Vectors 2017 10(Suppl 2):534

    Published on: 9 November 2017

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