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Credelio™ (lotilaner; Elanco) is indicated for the treatment ... and tick infestations on cats at a recommended lotilaner dose rate of 6–24 mg/kg. ... This study evaluated the efficacy and safety of lotilaner fol...
The New World screwworm fly, Cochliomyia hominivorax..., is widely distributed across South America. This parasitic insect is a significant cause of primary myiasis in animals, including dogs. There is an urgent ...
Studies show that the novel isoxazoline, lotilaner (Credelioâ„¢ CAT; Elanco Animal Health),...
Throughout Japan, Korea and China, Haemaphysalis longicornis ticks are vectors of Babesia gibsoni..., which causes severe and progressive anemia in dogs. This study evaluated the efficacy of a single administrati...
With the geographical expansion of tick species and increased recognition of pathogens they transmit, there is a requirement for safe and rapidly effective control measures for dogs. Lotilaner, a novel isoxazolin...
A blinded, randomized, negative controlled laboratory study was conducted to evaluate the efficacy of lotilaner (CredelioTM, Elanco) when administered orally to dogs, against experimentally induced adult flea inf...
There is a continuing need for novel approaches to tick control in dogs. One such approach lies in the ability of lotilaner (Credelioâ„¢)..., an isoxazoline with a rapid onset of action, to provide sustained effica...
Lotilaner is a new oral ectoparasiticide from the...S...-enantiomer in flavoured chewable tablets (Credelioâ„¢). The pharmacokinetics of lotilaner were thoroughly determined after intravenous and oral...
Lotilaner (Credelio™, Elanco), a novel isoxazoline ... development program, studies were undertaken to investigate lotilaner’s initial and sustained efficacy and speed...
CredelioTM (lotilaner) is an oral ectoparasiticide from the isoxazoline...S...-enantiomer in flavoured chewable tablets. The pharmacokinetics of lotilaner were investigated after intravenous or oral administratio...
Lotilaner is a new isoxazoline developed as an...
Oral administration of lotilaner flavoured chewable tablets (Credelio™, Elanco) ... A study was undertaken in Europe to confirm lotilaner’s safety and anti-tick efficacy in...
The isoxazolines are a novel class of parasiticides that are potent inhibitors of γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and, to a lesser extent, of inhibitory glutamate-gated chloride chann...
Lotilaner is a novel isoxazoline developed for oral administration to dogs. In laboratory studies, lotilaner was shown to be safe and to ... safety and palatability of three monthly doses of lotilaner flavoured c...
Preclinical studies have shown that the novel isoxazoline, lotilaner (Credelioâ„¢, Elanco) administered orally to...
The ascarid, Toxocara canis, is a common and important zoonotic intestinal nematode parasite that infects dogs globally. An effective treatment that kills any pre-patent stages of immature T. canis...could additi...
Dirofilaria immitis,...a globally distributed filarial parasite of dogs, is known to cause serious or fatal cardiopulmonary disease. Client-owned dogs were enrolled in a clinical field study in the USA to evaluat...
The combination of milbemycin oxime (MO) and lotilaner (Credelio® Plus) is a novel systemic endectocide that provides month-long effectiveness in dogs after a single oral treatment. The safety of Credelio®...Plus...
The speed with which acaricides paralyze and kill ticks is relevant to impeding pathogen transmission. The objective of this study was to assess early-onset lotilaner effects on the motility and weights of Amblyo...
A pivotal randomised, blinded, positive-controlled, multicentre, European field study was conducted to evaluate the effectiveness and safety of a novel combination tablet of lotilaner and milbemycin oxime (Credel...
The hookworm, Ancylostoma caninum, is a common and important zoonotic intestinal nematode parasite that infects dogs globally. Both the immature and adult stages of A. caninum...ingest large volumes of blood duri...
A randomised, blinded, positive controlled, multicentre, Good Clinical Practice-compliant, pivotal field study was conducted to evaluate the effectiveness and safety of a new combination of lotilaner + milbemycin...
Effective control of tick infestations on dogs is important to reduce the risk of transmission of bacterial, viral, and protozoal pathogens. Laboratory studies were initiated to determine the efficacy of lotilaner
From three days following host attachment, the Australian paralysis tick, Ixodes holocyclus..., secretes a neurotoxin that annually causes paralysis in approximately 10,000 domestic pets. Lotilaner, a novel isoxa...
Lotilaner (Credelioâ„¢) is the newest member of ... developed to treat canine ectoparasitism. Administered orally, lotilaner is rapidly absorbed with peak blood levels ... was undertaken to determine the earliest o...
The oral systemic efficacy of lotilaner (Credelioâ„¢, Elanco) was evaluated against Demodex spp. in naturally infested dogs with generalized demodicosis.
Lotilaner (Credelioâ„¢, Elanco) is a novel ... oral administration to dogs. The safety of lotilaner flavoured chewable tablets was investigated in a ... puppies starting at 8 weeks of age. Lotilaner was administere...
The ixodid tick Amblyomma cajennense (sensu lato) complex, widespread throughout South and Central America, is also present in Mexico, Texas and Florida. As a vector of Rickettsia rickettsii, and potentially of o...
Dogs worldwide are at risk of Babesia spp. infections. Preventive efficacy of lotilaner tablets (Credelioâ„¢, Elanco) against Babesia canis was evaluated in two studies.
Lotilaner is a new member of the isoxazoline ... infestations in cats. This laboratory study with lotilaner vanilla-yeast flavoured chewable tablets (CredelioTM..., Elanco) investigated the safety in healthy kitt...
There is a continuing need for novel approaches to tick infestations treatment and control in cats. Lotilaner, an isoxazoline with rapid onset of action ... studies. A study was undertaken to confirm lotilaner’s ...
Lotilaner is approved for dogs as a chewable ... assessing the efficacy and speed of kill of lotilaner in cats against Ctenocephalides felis fleas following a single oral administration, at the minimum recommende...
Lotilaner, approved for dogs as a chewable tablet...TM...chewable tablets for cats), to meet the need for an easy to use, safe and rapidly effective parasiticide. It is a valid cat- and owner-friendly alternative...
Ectoparasiticide purchase transactions over a 12-month period were evaluated for 626 US veterinary hospitals to determine dose purchase timing and identify consequent gaps between dose administration in dogs. Ora...
A spot-on formulation containing fluralaner (280 mg/ml) plus moxidectin (14 mg/ml) (Bravecto® Plus) has been developed to provide broad spectrum parasite protection for cats. The effectiveness and safety of th...
Recent reports indicate that the isoxazoline compounds have the potential to provide safe and effective treatment of canine generalized demodicosis, a condition that has been traditionally difficult to cure. C...
The human botfly, Dermatobia hominis, is a common cause of furuncular myiasis in dogs in Latin America. Lesions can be single or multiple, each harboring an individual larva, presented as an erythematous nodule t...
Haemaphysalis longicornis ticks represent an ectoparasitic health threat to dogs. This study evaluated the immediate and persistent efficacy of orally administered fluralaner for control of this tick.
The longer the duration of protection of an acaricide against canine infestation with Ixodes holocyclus, the lower the risk of gaps in tick control programs that will place dogs at risk of potentially fatal tick-...
The parthenogenic reproductive ability of Haemaphysalis longicornis, facilitating quick life cycle completion and rapid geographic spread and its pathogen vector potential make infestations a risk to human and ca...
The Australian paralysis tick, Ixodes holocyclus, causes tick paralysis in dogs and cats in the eastern coastal regions of Australia. Prevention is the best option to protect dogs against this potentially fatal d...
Trichodectes canis is a small chewing louse found globally that primarily infests dogs. Limited information is available on the efficacy of isoxazolines against infestation with the chewing louse. In the present ...
Dirofilaria immitis, Leishmania infantum and Toxoplasma gondii are zoonotic parasites which can affect domestic cats. Considering the lack of published data from the local feline population, this study aimed to a...
Compliance failure with administration of heartworm (HW) disease preventives has been reported as the main contributor to HW disease incidence in medicalized dogs. This study aimed to evaluate purchase complia...
Compliant ectoparasiticide product use is a comprehensive way to control ticks and reduce the risk of tick-borne pathogen transmission to dogs. Because the systemically acting isoxazoline ectoparasiticides req...
This study describes the effectiveness of a novel active pharmaceutical ingredient, fluralaner (isoxazoline class), against important ectoparasites infesting cattle in Brazil.
Tick infestations can cause direct deleterious effects to dogs as a result of tick blood-feeding, and indirectly ticks can transmit disease agents that can be detrimental to the health of both dogs and humans....
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