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Table 4 Newly-discovered GPCRs identified by ensemble*†

From: Identification of novel arthropod vector G protein-coupled receptors

Sequence ID Species Prediction likelihood value Evidence BLAST sequence name
AAEL013430-PA Ae. aegypti 0.346 ScanPROSITE and BLAST and I-TASSER putative GPCR class a orphan receptor 5
AAEL000818-PA Ae. aegypti 0.188 ScanPROSITE and BLAST class C metabotropic glutamate-like G- protein coupled receptor GPRmgl4, putative
AGAP002229-PA An. gambiae 0.691 ScanPROSITE and BLAST serotonin receptor
AGAP004930-PA An. gambiae 0.658 ScanPROSITE and BLAST and I-TASSER G protein coupled receptor
AGAP000383-PA An. gambiae 0.480 ScanPROSITE and BLAST G protein coupled receptor
AGAP005229-PA An. gambiae 0.440 ScanPROSITE and BLAST and I-TASSER G protein coupled receptor
AGAP000606-PA An. gambiae 0.411 ScanPROSITE and BLAST alpha-2 adrenergic receptor
AGAP013324-PA An. gambiae 0.409 ScanPROSITE and BLAST G protein-coupled receptor
AGAP008703-PA An. gambiae 0.278 ScanPROSITE and BLAST and I-TASSER G protein-coupled receptor
AGAP008237-PA An. gambiae 0.250 BLAST and I- TASSER G protein-coupled receptor 143
AGAP011320-PA An. gambiae 0.236 ScanPROSITE and BLAST and I-TASSER Beta-3 adrenergic receptor
AGAP012824-PA An. gambiae 0.167 ScanPROSITEand BLAST and I-TASSER tachykinin receptor
AGAP011646-PA An. gambiae 0.112 ScanPROSITE and BLAST class C metabotropic glutamate-like G-protein coupled receptor
PHUM074100-PA Pe. humanus 0.375 ScanPROSITE and BLAST Frizzled-7
PHUM010590-PA Pe. humanus 0.342 ScanPROSITE and I-TASSER PREDICTED: cadherin EGF LAG seven-pass G-type receptor 3-like
PHUM423330-PA Pe. humanus 0.289 ScanPROSITE and I-TASSER N/A
PHUM447490-PA Pe. humanus 0.250 ScanPROSITE and I-TASSER neuropeptide receptor A31
PHUM618870-PA Pe. humanus 0.208 ScanPROSITE and I-TASSER G protein-coupled receptor
PHUM128700-PA Pe. humanus 0.167 ScanPROSITE and I-TASSER G protein-coupled receptor
AAEL005994-PA Ae. aegypti 0.278 Unconfirmed uridine cytidine kinase i
AAEL002694-PA Ae. aegypti 0.250 Unconfirmed transmembrane protein 87A
AAEL000851-PA Ae. aegypti 0.217 Unconfirmed N/A
AAEL010852-PA Ae. aegypti 0.214 Unconfirmed Transmembrane protein 145
AGAP000130-PA An. gambiae 0.430 Unconfirmed PREDICTED: latrophilin 2-like
AGAP005356-PA An. gambiae 0.423 Unconfirmed PREDICTED: alpha-1A adrenergic receptor-like
AGAP011701-PA An. gambiae 0.400 Unconfirmed GPRmgl4
AGAP004783-PA An. gambiae 0.227 Unconfirmed neuropeptide receptor A16
AGAP007896-PA An. gambiae 0.141 Unconfirmed sprinter
PHUM596180-PA Pe. humanus 0.476 Unconfirmed transmembrane protein 145
PHUM288590-PA Pe. humanus 0.136 Unconfirmed N/A
  1. † Sequences were predicted using the Ensemble* classifier. Independent validation was performed using ScanPROSITE, I-TASSER, and homology to GPCRs in other organisms as determined by a BLAST search of the NCBI nr database. Status as a newly-discovered GPCR was contingent upon identification by the Ensemble* classifier and the existence of no contrary evidence, while confirmed GPCRs also had to be validated by at least two independent methods.