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Figure 1 | Parasites & Vectors

Figure 1

From: Leishmania braziliensis replication protein A subunit 1: molecular modelling, protein expression and analysis of its affinity for both DNA and RNA

Figure 1

Multiple alignment of RPA-1 sequences from trypanosomatids and evolutionarily divergent organisms. Sequences were aligned with T-Coffee at the ExPASy. C_f, C. fasciculata (UniProtKB/Swiss-Prot: Q23696.1); H_s, H. sapiens (NCBI: NP_002936.1); L_a, L. amazonensis (GenBank: AAR84278.1); L_b, L. braziliensis (this work; GeneDB: LbrM.28.1990); S_c, S. cerevisiae (GenBank: AAC04960.1); T_b, T. brucei (GeneDB: Tb927.11.9130); T_c, T. cruzi (GeneDB: TcCLB.510901.60); U_m, U. maydis (GenBank: AAU05383.1). Numbers on the right correspond to the amino acid position in the sequence. An asterisk means that amino acids are identical in all sequences shown in the alignment. A colon means that conserved substitutions are observed, and a period means that semi-conserved substitutions are observed. The location of the OB-fold domains (DBD) is indicated by brackets on the sequences. Letters in colors represent the potential phosphorylation sites in L. amazonensis and L. braziliensis RPA-1 proteins: red for serine, blue for threonine and green for tyrosine residues. The conserved zinc finger motif is indicated in magenta.

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