Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa
© Braae et al. 2015
Received: 6 May 2015
Accepted: 5 June 2015
Published: 12 June 2015
This study aimed to map the distribution of Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa. These two major neglected tropical diseases are presumed to be widely distributed in Africa, but currently the level of co-distribution is unclear.
A literature search on T. solium taeniosis/cysticercosis was performed to compile all known studies on the presence of T. solium and apparent prevalence of taeniosis and porcine cysticercosis in Africa. Studies were geo-referenced using an online gazetteer. A Bayesian framework was used to combine the epidemiological data on the apparent prevalence with external information on test characteristics to estimate informed district-level prevalence of taeniosis and porcine cysticercosis. Districts with T. solium taeniosis/cysticercosis presence were cross-referenced with the Global Neglected Tropical Diseases Database for schistosomiasis presence.
The search strategies identified 141 reports of T. solium in Africa from 1985 to 2014 from a total of 476 districts in 29 countries, 20 with porcine cysticercosis, 22 with human cysticercosis, and 16 with taeniosis, in addition to 2 countries identified from OIE reports. All 31 countries were considered, on national scale, to have co-distribution with schistosomiasis. Presence of both parasites was confirmed in 124 districts in 17 countries. The informed prevalence of taeniosis and porcine cysticercosis were estimated for 14 and 41 districts in 10 and 13 countries, respectively.
With the paucity of data, T. solium infection is grossly under-reported and expected to be more widespread than this study suggests. In areas where co-distribution occurs there is a need for increased emphasis on evaluation of integrated intervention approaches for these two helminth infections and allocation of resources for evaluating the extent of adverse effects caused by mass drug administration.
KeywordsAfrican pig population Co-distribution Cysticercosis Mapping Prevalence Schistosomiasis Taenia solium
The major neglected tropical diseases, Taenia solium taeniosis/cysticercosis and schistosomiasis caused by Schistosoma mansoni or S. haematobium are presumed to be widely distributed in Africa. Taenia solium taeniosis/cysticercosis has been reported as an emerging disease in different regions of Africa [1, 2], but currently the exact distribution remains unclear. Reported prevalences of T. solium taeniosis and cysticercosis in African countries are not extensive and are further complicated by the lack of ‘gold standard’ tests for diagnosis. Diagnosis has so far been performed using several diagnostic tests with varying sensitivity and specificity [3–5]. Therefore, estimating informed prevalence is important to determine the actual disease burden. Informed prevalence is an estimation of the true prevalence based on the apparent prevalence while factoring in the imperfections in sensitivity and specificity of the diagnostic tests used. The distribution of schistosomiasis in Africa has been more extensively investigated than T. solium taeniosis/cysticercosis and this has allowed for country level prevalence and risk estimation of schistosomiasis for all African countries .
The World Health Organization (WHO) is aiming for elimination of schistosomiasis by 2020 and the road map for elimination of T. solium taeniosis/cysticercosis is under consideration by the WHO . The WHO strategy for schistosomiasis elimination is primarily mass drug administration (MDA) of preventive chemotherapy as the main intervention tool. The WHO advocates that MDA against schistosomiasis will reduce morbidity and decrease transmission, which might also carry the added benefit of controlling other infections in co-endemic areas such as T. solium taeniosis/cysticercosis . A way forward for control of T. solium is integration with schistosomiasis control programmes. However, the potential benefit of an integrated control effort against the two parasites has yet to be evaluated. The anthelminthic drug used against schistosomiasis is praziquantel (PZQ) because of its safety profile, easy administration, and mild side-effects . The current recommended dose of PZQ for treatment of schistosomiasis is 40 mg/kg as a single dose . PZQ has proved highly efficacious against taeniosis at a dose of 5–10 mg/kg , and the drug can therefore be used against both parasites. However, the dose recommended for schistosomiasis treatment may increase the risk of seizures in people who are suffering from human cysticercosis where the larvae are lodged in the central nervous system (neurocysticercosis, NCC). Even a single dose, lower than that recommended for schistosomiasis treatment, has been reported to induce seizures . Flisser and colleagues  reported suspected cases of NCC based on clinical signs following treatment with 5 mg/kg PZQ, and in a follow-up of 2452 participants subjected to an MDA using PZQ at 5 mg/kg where of 1.3 % reported complaints of severe headache after treatment. Although MDA has been widely applied for control of schistosomiasis in Africa, the safety of PZQ in MDA in communities where schistosomiasis and NCC coexist is yet to be systematically assessed.
The distribution of T. solium taeniosis/cysticercosis in Africa is unclear and up-to-date prevalence maps do not exist. The distribution of schistosomiasis is also to some extent uncertain, but through the work of the Global Neglected Tropical Diseases Database (GNTD; http://www.gntd.org), a prevalence map based on more than 20,000 locations can be created. The database is continuously updated with the goal to use the information for public health campaigns against schistosomiasis. With the launch of online virtual globes such as Google Earth, online gazetteers have become a useful tool for geo-referencing of locations and also disease distribution. The GNTD has used online gazetteers in order to geographically locate the distribution of schistosomiasis , which in turn have been utilised for modelling past and future distribution maps of infection [13–15]. This paper aims to compile the available information on T. solium taeniosis/cysticercosis in Africa and use the information to estimate the informed prevalence of taeniosis and porcine cysticercosis on a district level, and determine districts were co-distribution of T. solium taeniosis/cysticercosis and schistosomiasis occurs.
The following data were included in this study 1) peer-reviewed studies of T. solium taeniosis/cysticercosis in Africa, 2) “grey literature” on T. solium taeniosis/cysticercosis presence in Africa which consisted of informally published written materials such as reports and theses, 3) official reports of national pig populations in Africa available through national census data and FAOSTAT , the statistical database of the Food and Agriculture Organization of the United Nations, 4) porcine cysticercosis reports from the World Organisation for Animal Health (OIE), and 5) the schistosomiasis prevalence map currently used by the WHO for assessing MDA intervals .
We performed a literature search using PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) with date restriction from 01-01-1985 to 05-01-2015 using the following search term: (solium OR Tapeworm OR Taeniasis OR Taeni* OR Taeniosis OR Neurocysticercosis OR Cysticerc* OR cellulosae) AND (Algeria OR Angola OR Benin OR Botswana OR Burkina Faso OR Burundi OR Cameroon OR Central African Republic OR Chad OR Congo OR Zaire OR Cote d’Ivoire OR Ivory Coast OR Djibouti OR Egypt OR Equatorial Guinea OR Eritrea OR Ethiopia OR Gabon OR Gambia OR Ghana OR Guinea OR Guinea-Bissau OR Kenya OR Lesotho OR Liberia OR Libya OR Madagascar OR Malawi OR Mali OR Mauritania OR Morocco OR Mozambique OR Namibia OR Niger OR Nigeria OR Rwanda OR Senegal OR Sierra Leone OR Somalia OR South Africa OR South Sudan OR Sudan OR Swaziland OR Tanzania OR Togo OR Tunisia OR Uganda OR Zambia OR Zimbabwe). We also searched other databases such as Google Scholar (http://scholar.google.com), Thomson Reuter’s Web of Knowledge (http://www.wokinfo.com), Cab Direct (http://www.cabdirect.org), Société de Pathologie Exotique (http://www.pathexo.fr/), ProMED (http://www.isid.org), and African Journals Online (http://www.ajol.info) using the following keywords: “Taenia solium”, “porcine cysticercosis”, “Cysticercus cellulosae”, “neurocysticercosis”, “human cysticercosis”, “taeniosis”, and “taeniasis”. In addition, references found in suitable articles were also investigated to compile all known studies on presence of T. solium and prevalence of taeniosis and porcine cysticercosis.
Taenia solium taeniosis/cysticercosis cases were geo-referenced by extracting geographic information on the study quoted in the literature. If no geographic coordinates were provided by the authors, the geographic location was found by using the online gazetteer ‘Geonames’ (http://geonames.org). Distribution of schistosomiasis was extracted as point data from the GNTD and overlaid on the district-level occurrence of T. solium taeniosis/cysticercosis to determine districts with co-distribution.
Parameters used for the probabilistic constraints for sensitivity and specificity of the different diagnostic tests using the 95 % confidence intervals reported in key papers
Data on the African pig population were extracted from national livestock census reports or FAOSTAT database if national census data were missing, and divided with the countries human population obtained from the UN to yield a per capita pig population . Data on recent (2005 to 2014) reports of porcine cysticercosis that have been submitted to the OIE were extracted from the OIE database WAHID Interface . Reports from the database are in 6 months intervals with disease status divided into 5 categories: disease was present, suspected but not confirmed, not reported during this period, never reported, and no information available. We have pooled the data into one ‘disease status’ during the period 2005 to 2014, ranking the five categories in the following order 1) disease was present, 2) suspected but not confirmed, 3) not reported during this period, 4) never reported, and 5) no information available.
Presence of Taenia solium cysticercosis recorded in African countries from 1985 to 2014. Taenia solium taeniosis was not confirmed unless otherwise stated
No of References
Central African Republic
Democratic Republic of Congo
According to the ranking of OIE’s reports of porcine cysticercosis for 2005–2014, the disease was present in 18 African countries and additionally suspected in three: Equatorial Guinea, Kenya, and Tanzania. For both Kenya and Tanzania, literature confirms the presence of T. solium during this period [28–31], but no data exist from Equatorial Guinea. This indicates insufficient national reporting to the OIE. In 2 of the 18 countries with porcine cysticercosis according to the OIE, i.e., Congo and Niger, no other documentation of T. solium presence could be found.
Studies included in the calculation of informed prevalence of Taenia solium taeniosis and porcine cysticercosis by Bayesian inference
Democratic Republic of Congo
Taenia solium taeniosis/cysticercosis was confirmed in 476 districts in 29 African countries based on the literature search. According to the OIE reports from 2005 to 2014, the parasite is present in additional two countries, totalling 31 endemic countries in Africa. The findings correspond well to the WHO risk map for cysticercosis previously published , but have a much higher level of accuracy with distribution on district level in certain areas. With only 141 references identified from surveys in Africa, occurrence is probably grossly underreported. Several countries e.g. Guinea, Sierra Leone, and Liberia, with relatively large porcine populations still need to be investigated for T. solium presence, which emphasises the need for more research on disease distribution. However, this is complicated by the fact that T. solium has a focal distribution . Pig keeping is far from evenly distributed across the African continent, nor within single countries, region or even districts.
In all 31 countries where T. solium occurrence was documented, schistosomiasis and T. solium taeniosis/cysticercosis can be considered to co-exist. Data on the distribution of T. solium is sparse on the district level and more data is essential to construct more accurate co-distribution maps, but nonetheless co-distribution was confirmed in 124 districts in 17 countries. Identifying co-endemic clusters on the same administrative level as MDA is carried out in the respective countries will enable identification of communities at risk of adverse effects from treatment with PZQ due to NCC. Even at village level significant variation in disease distribution is expected for both schistosomiasis and T. solium taeniosis/cysticercosis, as transmission of the disease is dependent on the presences of the respective intermediate hosts. This can result in large differences in disease prevalence within small geographical areas. However, since inadequate sanitation is an important risk factor for both parasites, frequent overlaps would be expected.
According to the WHO, preventive chemotherapy against schistosomiasis is required in some districts of all sub-Saharan countries, except Lesotho where the disease is not endemic . More than 240 million people in Africa were in need of preventive chemotherapy against schistosomiasis in 2013 and just over 130 million of these were school-aged children . School-aged children typically make-up a relatively large proportion of the total population within African countries and are considered the main group at risk for severe schistosomiasis morbidity and main contributors to egg excretion . Taeniosis is however more equally distributed across age groups within the population , thus MDA of PZQ to school-aged children might therefore not be sufficient to significantly lower Taenia egg excretion within a community even though school-aged children make-up a large proportion of the population .
Currently there has been no monitoring or evaluation of MDA for schistosomiasis in communities where T. solium taeniosis/cysticercosis and schistosomiasis are co-distributed, which is highly warranted. Since the geographical distribution of T. solium remains to be fully elucidated in most African countries, the risk of adverse effects could be significantly underestimated. Several studies in Africa have confirmed the presence of human cysticercosis and specifically NCC in areas where schistosomiasis is endemic [36, 38–41]. Although NCC is considered more common in adults , children are also infected and in South Africa children down to the age of three have been found to suffer from NCC .
On-going control programmes in communities where pigs are kept or consumed, should be systematically monitored for adverse events that may incur from NCC in order to make precautionary implementations for future MDAs, such as determining prevalence of NCC in communities. Therefore, the number of pigs present in the communities, regions, and countries is an important key figure to obtain. Currently few African countries have performed a national census on livestock which makes the presumed rough estimates on national pig populations in Africa from FAOSTAT the only data available. However, the problem of NCC is not necessarily confined to areas where pigs are kept. Numerous accounts have shown that persons who neither raise pigs nor consume pork are also at risk of cysticercosis as people can accidently ingest T. solium eggs after coming into direct or indirect contact with tapeworm carriers, irrespective of their own cultural and religious practices or the presence of pigs [44–47]. Therefore, communication between the veterinary and public health sector is crucial for local authorities to get insight into the consequences of applying MDA to communities where schistosomiasis and T. solium taeniosis/cysticercosis are co-endemic.
Findings from the literature search indicate a discrepancy between the reports on the presence of porcine cysticercosis stated in the literature and that of which has been reported to the OIE. This may be due to porcine cysticercosis not being an international notifiable disease, which may lead to inconsistencies in reporting to the OIE by member states. There is a need to improve communication between the scientific community and OIE in addition to the respective member states from Africa to alleviate this problem.
The informed prevalences of taeniosis and porcine cysticercosis should be regarded as best estimates rather than absolute truths. Sensitivity and specificity are not necessarily intrinsic to the specific diagnostic test used, but affected by external factors , or by the intensity of the infection, which commonly vary among studies . The Bayesian inference does however give the best possible comparison and thereby provides a rough overview of the disease burden within certain areas in the affected countries. Unfortunately, it does not provide any information on the T. solium cysticercosis burden for any entire nation. This requires more detailed nationwide epidemiological surveys .
Allowing pigs to roam freely is a well-known risk factor for porcine cysticercosis [51, 52], but production type and management were not considered in the study. Likewise, no differentiation was made between studies performed at slaughter slabs and farms. There is consensus that pigs in endemic African countries often are screened for cysticercosis by tongue examination before being sent for slaughter, resulting in higher apparent prevalence on farms compared to slaughter slabs. This causes bias in the surveys performed at slaughter slabs, which will underestimate the prevalence of porcine cysticercosis, because pigs with high intensity infections have been eliminated from the sample.
Pinpointing the origin of T. solium cases is difficult because taeniosis is often asymptomatic and symptoms of NCC often occur between 2 and 5 years after infection . Thus, the subject would therefore require accurate long-term recollection of where and when the infection might have been contracted, and depending on travel history of the infected person the infection might not have been acquired at the same place as they were surveyed.
Although T. solium is reported from the majority of African countries it is still grossly under-reported and for many areas the co-distribution with schistosomiasis on district level is still unknown. In areas where T. solium and schistosomiasis is co-distributed, an increased emphasis should be put on evaluating an integrated intervention approach for these two helminth infections. Resources should be allocated to evaluate the extent of adverse effects caused by the MDA of PZQ as preventive treatment in areas where people suffer from NCC. On-going control programmes should therefore be monitored, but reaching the goal of eliminating T. solium will require a One Health approach addressing both human and animal health.
Dr Davies Pfukenyi from the Faculty of Veterinary Science, University of Zimbabwe for supplying us with T. solium data from Zimbabwe.
Role of funding source
The funder had no role in study design, data collection, analysis, interpretation of the data, or drafting of the manuscript. The corresponding author had full access to all data in the study and had the final responsibility for decision to submit for publication.
- Zoli A, Shey-Njila O, Assana E, Nguekam JP, Dorny P, Brandt J, et al. Regional status, epidemiology and impact of Taenia solium cysticercosis in Western and Central Africa. Acta Trop. 2003;87(1):35–42.PubMedGoogle Scholar
- Phiri IK, Ngowi H, Afonso S, Matenga E, Boa M, Mukaratirwa S, et al. The emergence of Taenia solium cysticercosis in Eastern and Southern Africa as a serious agricultural problem and public health risk. Acta Trop. 2003;87(1):13–23.PubMedGoogle Scholar
- Deckers N, Dorny P. Immunodiagnosis of Taenia solium taeniosis/cysticercosis. Trends Parasitol. 2010;26(3):137–44.PubMedGoogle Scholar
- Dorny P, Phiri IK, Vercruysse J, Gabriel S, Willingham AL, Brandt J, et al. A Bayesian approach for estimating values for prevalence and diagnostic test characteristics of porcine cysticercosis. Int J Parasitol. 2004;34(5):569–76.PubMedGoogle Scholar
- Gonzalez AE, Cama V, Gilman RH, Tsang VCW, Pilcher JB, Chavera A, et al. Prevalence and comparison of serologic assays, necropsy, and tongue examination for the diagnosis of porcine cysticercosis in Peru. Am J Trop Med Hyg. 1990;43(2):194–9.PubMedGoogle Scholar
- Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis. 2006;6(7):411–25.PubMedGoogle Scholar
- WHO. Working to overcome the global impact of neglected tropical diseases - First WHO report on neglected tropical diseases. Geneva: World Health Organization; 2010.Google Scholar
- WHO. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: Report of a WHO Expert Committee. World Health Organization; 2002.Google Scholar
- Pawlowski ZS. Efficacy of low doses of praziquantel in taeniasis. Acta Trop. 1991;48(2):83–8.Google Scholar
- Torres JR. Use of praziquantel in populations at risk of neurocysticercosis. Rev Inst Med Trop Sao Paulo. 1989;31(4):290.PubMedGoogle Scholar
- Flisser A, Madrazo I, Plancarte A, Schantz P, Allan J, Craig P, et al. Neurological symptoms in occult neurocysticercosis after single taeniacidal dose of praziquantel. Lancet. 1993;342(8873):748.PubMedGoogle Scholar
- Hurlimann E, Schur N, Boutsika K, Stensgaard AS, de Himpsl ML, Ziegelbauer K, et al. Toward an open-access global database for mapping, control, and surveillance of neglected tropical diseases. Plos Negl Trop Dis. 2011;5(12):e1404.PubMed CentralPubMedGoogle Scholar
- Stensgaard A-S, Utzinger J, Vounatsou P, Hürlimann E, Schur N, Saarnak CF, et al. Large-scale determinants of intestinal schistosomiasis and intermediate host snail distribution across Africa: does climate matter? Acta Trop. 2013;128(2):378–90.PubMedGoogle Scholar
- Schur N, Hürlimann E, Garba A, Traoré MS, Ndir O, Ratard RC, et al. Geostatistical model-based estimates of schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa. Plos Negl Trop Dis. 2011;5(6), e1194.PubMed CentralPubMedGoogle Scholar
- Schur N, Hürlimann E, Stensgaard A-S, Chimfwembe K, Mushinge G, Simoonga C, et al. Spatially explicit Schistosoma infection risk in eastern Africa using Bayesian geostatistical modelling. Acta Trop. 2013;128(2):365–77.PubMedGoogle Scholar
- FAO (Food and Agriculture Organization of the United Nations) statistical databases. [http://faostat3.fao.org/home/index.html].
- Global Health Observatory Map Gallery. [http://gamapserver.who.int/mapLibrary/Files/Maps/Schistosomiasis_2012.png].
- Pönnighaus JM, Nkhosa P, Baum HP. Cutaneous manifestation of cysticercosis. Hautarzt. 2001;52(12):1098–100.PubMedGoogle Scholar
- Berkvens D, Speybroeck N, Praet N, Adel A, Lesaffre E. Estimating disease prevalence in a Bayesian framework using probabilistic constraints. Epidemiology. 2006;17(2):145–53.PubMedGoogle Scholar
- Speybroeck N, Devleesschauwer B, Joseph L, Berkvens D. Misclassification errors in prevalence estimation: Bayesian handling with care. Int Public Health J. 2013;58(5):791–5.Google Scholar
- Devleesschauwer B, Torgerson P, Charlier J, Levecke B, Praet N, Roelandt S, et al. Prevalence: Tools for prevalence assessment studies. R package version 0.3.0. 2014. Available: http://cran.r-project.org/package=prevalence.Google Scholar
- World Population Prospects: The 2012 Revision. [http://esa.un.org/wpp/].
- OIE. World Animal Health Information Database (WAHID) Interface. 2014.Google Scholar
- Menan EIH, Rouamba E, Ouhon J, Nebavi NGF, Adjetey TAK, Barro-Kiki PCMK, et al. Intestinal helminthiases: results of five years of parasitological coprology at the Pasteur Institute of Cocody (Abidjan - Côte d’Ivoire). Med Afr Noire. 1997;44(7):415–9.Google Scholar
- Evans AC, Joubert JJ. Intestinal helminths of hospital patients in Kavango territory, Namibia. Trans R Soc Trop Med Hyg. 1989;83(5):681–3.PubMedGoogle Scholar
- Mishra G, N’depo A. Les cysticerques des animaux abattus à l’abattoir de Port-Bouet (Abidjan). Rev Elev Med Vet Pays Trop. 1978;31(4):431–6.PubMedGoogle Scholar
- Motsepe T, Ackerman D. Spinal and vertebral neurocysticercosis in an HIV-positive female patient: case report. South Afr J Epidemiol Infect. 2012;27(3):133–6.Google Scholar
- Mellau BL, Nonga HE, Karimuribo ED. Slaughter stock abattoir survey of carcasses and organ/offal condemnations in Arusha region, northern Tanzania. Trop Anim Health Pro. 2011;43(4):857–64.Google Scholar
- Mkupasi EM, Ngowi HA, Nonga HE. Prevalence of extra-intestinal porcine helminth infections and assessment of sanitary conditions of pig slaughter slabs in Dar es Salaam city, Tanzania. Trop Anim Health Pro. 2011;43(2):417–23.Google Scholar
- Eshitera EE, Githigia SM, Kitala P, Thomas LF, Fevre EM, Harrison LJS, et al. Prevalence of porcine cysticercosis and associated risk factors in Homa Bay District, Kenya. BMC Vet Res. 2012;8:234.PubMed CentralPubMedGoogle Scholar
- Komba EV, Kimbi EC, Ngowi HA, Kimera SI, Mlangwa JE, Lekule FP, et al. Prevalence of porcine cysticercosis and associated risk factors in smallholder pig production systems in Mbeya region, southern highlands of Tanzania. Vet Parasitol. 2013;198(3):284–91.PubMedGoogle Scholar
- Countries and areas at risk of cysticercosis, 2009. [http://gamapserver.who.int/mapLibrary/Files/Maps/Global_cysticercosis_2009.png].
- Devleesschauwer B, Aryal A, Joshi DD, Rijal S, Sherchand JB, Praet N, et al. Epidemiology of Taenia solium in Nepal: is it influenced by the social characteristics of the population and the presence of Taenia asiatica? Trop Med Int Health. 2012;17(8):1019–22.PubMedGoogle Scholar
- WHO. Schistosomiasis: number of people treated worldwide in 2013. Wkly Epidemiol Rec. 2015;90:25–32.Google Scholar
- Naus CW, Booth M, Jones FM, Kemijumbi J, Vennervald BJ, Kariuki CH, et al. The relationship between age, sex, egg‐count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community. Trop Med Int Health. 2003;8(6):561–8.PubMedGoogle Scholar
- Mwape KE, Phiri IK, Praet N, Muma JB, Zulu G, Van den Bossche P, et al. Taenia solium infections in a Rural Area of Eastern Zambia - A community based study. Plos Negl Trop Dis. 2012;6(3):e1594.PubMed CentralPubMedGoogle Scholar
- Kyvsgaard NC, Johansen MV, Carabin H. Simulating transmission and control of Taenia solium infections using a Reed-Frost stochastic model. Int J Parasitol. 2007;37(5):547–58.PubMedGoogle Scholar
- Kanobana K, Praet N, Kabwe C, Dorny P, Lukanu P, Madinga J, et al. High prevalence of Taenia solium cysticerosis in a village community of Bas-Congo, Democratic Republic of Congo. Int J Parasitol. 2011;41(10):1015–8.PubMedGoogle Scholar
- Mwanjali G, Kihamia C, Kakoko DVC, Lekule F, Ngowi H, Johansen MV, et al. Prevalence and risk factors associated with human Taenia solium infections in Mbozi district, Mbeya Region, Tanzania. Plos Negl Trop Dis. 2013;7(3):e2102.PubMed CentralPubMedGoogle Scholar
- Weka RP, Ikeh EI, Kamani J. Seroprevalence of antibodies (IgG) to Taenia solium among pig rearers and associated risk factors in Jos metropolis, Nigeria. J Infect Dev Ctries. 2013;7(2):67–72.Google Scholar
- Prado-Jean A, Kanobana K, Druet-Cabanac M, Nsengyiumva G, Dorny P, Preux PM, et al. Combined use of an antigen and antibody detection enzyme-linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi. Trop Med Int Health. 2007;12(7):895–901.PubMedGoogle Scholar
- Praet N, Speybroeck N, Rodriguez-Hidalgo R, Benitez-Ortiz W, Berkvens D, Brandt J, et al. Age-related infection and transmission patterns of human cysticercosis. Int J Parasitol. 2010;40(1):85–90.PubMedGoogle Scholar
- Thomson AJ, De Villiers JC, Moosa A, Van Dellen J. Cerebral cysticercosis in children in South Africa. Ann Trop Paediatr. 1984;4(2):67–77.PubMedGoogle Scholar
- Schantz PM, Moore AC, Muñoz JL, Hartman BJ, Schaefer JA, Aron AM, et al. Neurocysticercosis in an orthodox Jewish community in New York City. N Engl J Med. 1992;327(10):692–5.PubMedGoogle Scholar
- Al Shahrani D, Frayha HH, Dabbagh O, Al Shail E. First case of neurocysticercosis in Saudi Arabia. J Trop Pediatr. 2003;49(1):58–60.PubMedGoogle Scholar
- Khan FY, Imam YZ, Kamel H, Shafaee M. Neurocysticercosis in Qatari patients: case reports. Travel Med Infect Dis. 2011;9(6):298–302.PubMedGoogle Scholar
- Hira PR, Francis I, Abdella NA, Gupta R, Al-Ali FM, Grover S, et al. Cysticercosis: imported and autochthonous infections in Kuwait. Trans R Soc Trop Med Hyg. 2004;98(4):233–9.PubMedGoogle Scholar
- Begg CB. Biases in the assessment of diagnostic tests. Stat Med. 1987;6(4):411–23.PubMedGoogle Scholar
- Greiner M, Gardner I. Epidemiologic issues in the validation of veterinary diagnostic tests. Prev Vet Med. 2000;45(1):3–22.PubMedGoogle Scholar
- Devleesschauwer B, Ale A, Torgerson P, Praet N, de Noordhout CM, Pandey BD, et al. The burden of parasitic zoonoses in Nepal: a systematic review. Plos Negl Trop Dis. 2014;8(1):e2634.PubMed CentralPubMedGoogle Scholar
- Pondja A, Neves L, Mlangwa J, Afonso S, Fafetine J, Willingham AL, et al. Prevalence and risk factors of porcine cysticercosis in Angonia District, Mozambique. Plos Negl Trop Dis. 2010;4(2):e594.PubMed CentralPubMedGoogle Scholar
- Sikasunge CS, Phiri IK, Phiri AM, Dorny P, Siziya S, Willingham III AL. Risk factors associated with porcine cysticercosis in selected districts of Eastern and Southern provinces of Zambia. Vet Parasitol. 2007;143(1):59–66.PubMedGoogle Scholar
- Garcia HH, Gonzalez AE, Evans CAW, Gilman RH, Cysticercosis Working Grp P. Taenia solium cysticercosis. Lancet. 2003;362(9383):547–56.PubMed CentralPubMedGoogle Scholar
- Krecek RC, Michael LM, Schantz PM, Ntanjana L, Smith MF, Dorny P, et al. Corrigendum to “Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa” [Vet. Parasitol. 154(2008) 38–47]. Vet Parasitol. 2011;183(1–2):198–200.Google Scholar
- Krecek RC, Michael LM, Schantz PM, Ntanjana L, Smith MF, Dorny P, et al. Prevalence of Taenia solium cysticercosis in swine from a community-based study in 21 villages of the Eastern Cape Province, South Africa. Vet Parasitol. 2008;154(1–2):38–47.PubMedGoogle Scholar
- Praet N, Verweij JJ, Mwape KE, Phiri IK, Muma JB, Zulu G, et al. Bayesian modelling to estimate the test characteristics of coprology, coproantigen ELISA and a novel real-time PCR for the diagnosis of taeniasis. Trop Med Int Health. 2013;18(5):608–14.PubMedGoogle Scholar
- Tomlinson M, Adams V, Chopra M, Jooste P, Strydom E, Dhansay A. Survey of iodine deficiency and intestinal parasitic infections in school-going children: Bie Province, Angola. Public Health Nutr. 2010;13(9):1314.PubMedGoogle Scholar
- Goussanou JSE, Kpodekon TM, Saegerman C, Azagoun E, Youssao AKI, Farougou S, et al. Spatial distribution and risks factors of porcine cysticercosis in southern Benin based meat inspection records. Int Res J Microbiol. 2013;4:188–96.Google Scholar
- Adjidé C, Bouteille B, Josse R, Adjidé-Szmidt V, Avodé D, Dumas M. Séroprévalence de la cysticercose dans la commune lacustre de Vekky, Département de l’Atlantique (Bénin). Bull Soc Pathol Exo. 1996;89(1):24–9.Google Scholar
- Avode DG, Bouteille B, Houngbe F, Adjien C, Adjide C, Houinato D, et al. Epilepsy, cysticercosis and neurocysticercosis in Benin. Eur Neurol. 1998;39(1):60–1.PubMedGoogle Scholar
- Houinato D, Ramanankandrasana B, Adjide C, Melaku Z, Josse R, Avode G, et al. Seroprevalence of cysticercosis in Benin. Trans R Soc Trop Med Hyg. 1998;92(6):621–4.PubMedGoogle Scholar
- Ganaba R, Praet N, Carabin H, Millogo A, Tarnagda Z, Dorny P, et al. Factors associated with the prevalence of circulating antigens to porcine cysticercosis in Three Villages of Burkina Faso. Plos Negl Trop Dis. 2011;5(1):e927.PubMed CentralPubMedGoogle Scholar
- Barro-Traoré F, Ouédraogo M, Sanou-Lamien A, Lompo-Goumbri O, Bassolé A, Sawadogo S, et al. Cysticercose sous-cutanée généralisée: à propos de six cas au Burkina Faso. Bull Soc Pathol Exot. 2008;101(1):17–9.PubMedGoogle Scholar
- Carabin H, Millogo A, Praet N, Hounton S, Tarnagda Z, Ganaba R, et al. Seroprevalence to the antigens of Taenia solium Cysticercosis among residents of Three Villages in Burkina Faso: A Cross-Sectional Study. Plos Negl Trop Dis. 2009;3(11):e555.PubMed CentralPubMedGoogle Scholar
- Fortunato S, Castagna B, Monteleone MR, Pierro R, Cringoli G, Bruschi F. Parasite prevalence in a village in Burkina Faso: the contribution of new techniques. J Infect Dev Ctries. 2014;8(5):670–5.PubMedGoogle Scholar
- Millogo A, Nitiéma P, Carabin H, Boncoeur‐Martel MP, Rajshekhar V, Tarnagda Z, et al. Prevalence of neurocysticercosis among people with epilepsy in rural areas of Burkina Faso. Epilepsia. 2012;53(12):2194–202.PubMedGoogle Scholar
- Napon C, Ouédraogo D, Diallo O, Kapto O, Kabore J. Syndrome de Wallenberg et neurocysticercose: à propos d’un cas à Ouagadougou, Burkina Faso. Bull Soc Pathol Exot. 2009;102(1):5–6.PubMedGoogle Scholar
- Nitiéma P, Carabin H, Hounton S, Praet N, Cowan L, Ganaba R, et al. Prevalence case‐control study of epilepsy in three Burkina Faso villages. Acta Neurol Scand. 2012;126(4):270–8.PubMed CentralPubMedGoogle Scholar
- Sakandé B, Traoré S, Kaboré J, Ouattara T, Soudré R. Parasitoses humaines au Burkina Faso, Approche histopathologique. Bull Soc Pathol Exot. 1998;91:217–20.PubMedGoogle Scholar
- Newell E, Vyungimana F, Geerts S, VanKerckhoven I, Tsang VCW, Engels D. Prevalence of cysticercosis in epileptics and members of their families in Burundi. Trans R Soc Trop Med Hyg. 1997;91(4):389–91.PubMedGoogle Scholar
- Diagana M, Nsengiyumva G, Tuillas M, Druet-Cabanac M, Bouteille B, Preux PM, et al. Électroencéphalogrammes réalisés chez 250 patients épileptiques dans une zone d’endémie cysticerquienne au Burund. Neurophysiol Clin. 2005;35(1):1–10.PubMedGoogle Scholar
- Nsengiyumva G, Druet-Cabanac M, Ramanankandrasana B, Bouteille B, Nsizabira L, Preux PM. Cysticercosis as a major risk factor for epilepsy in Burundi, East Africa. Epilepsia. 2003;44(7):950–5.PubMedGoogle Scholar
- Nzisabira L, Nsengiyumva G, Bouteille B, Ndayiragije A, Niyongabo T, Bigirimana V, et al. Cysticercosis in the province of Kayanza (Burundi). Bull Soc Pathol Exo. 1991;85(5):374–7.Google Scholar
- Assana E, Amadou F, Thys E, Lightowlers MW, Zoli AP, Dorny P, et al. Pig-farming systems and porcine cysticercosis in the north of Cameroon. J Helminthol. 2010;84(4):441–6.PubMed CentralPubMedGoogle Scholar
- Ngwing NAN, Pone JW, Mbida M, Pagnah AZ, Njakoi H, Bilong CFB. A preliminary analysis of some epidemiological factors involved in porcine cysticercosis in Bafut and Santa subdivisions, North West Region of Cameroon. Asian Pac J Trop Med. 2012;5(10):814–7.PubMedGoogle Scholar
- Pouedet MSR, Zoli AP, Nguekam, Vondou L, Assana E, Speybroeck N, et al. Epidemiological survey of swine cysticercosis in two rural communities of West-Cameroon. Vet Parasitol. 2002;106(1):45–54.PubMedGoogle Scholar
- Shey-Njila O, Zoli P, Awah-Ndukum J, Assana E, Byambas P, Dorny P, et al. Porcine cysticercosis in village pigs of North-West Cameroon. J Helminthol. 2003;77(4):351.PubMedGoogle Scholar
- Assana E, Zoli P, Sadou H, Vondou L, Pouedet M, Dorny P, et al. Prevalence of porcine cysticercosis in Mayo-Danay (North Cameroon) and Mayo-Kebbi (Southwest Chad). Rev Elev Med Vet Pays Trop. 2001;54(2):123–7.Google Scholar
- Marty P, Mary C, Pagliardini G, Quilici M, Le Fichoux Y. Deux cas de Cysticercose observé au Cameroun. Med Trop (Mars). 1986;46(2):181–3.Google Scholar
- Vondou L, Zoli A, Pouedet S, Assana E, Kamga Tokam A, Dorny P, et al. La taeniose/cysticercose à Taenia solium dans la Menoua (Ouest-cameroun). Parasite. 2002;9(3):271–4.PubMedGoogle Scholar
- Dongmo L, Druet-Cabanac M, Moyou S, Zebaze D, Njamnshi A, Sini V, et al. Cysticercose et épilepsie: étude cas-témoins dans la Vallée du Mbam, Cameroun. Bull Soc Pathol Exot. 2004;97(2):105–8.PubMedGoogle Scholar
- Elliott I, Jerome A, Angwafor SA, Smith ML, Takougang I, Noh J, et al. Epilepsy and cysticercosis in North-West Cameroon: A serological study. Seizure. 2013;22(4):283–6.PubMedGoogle Scholar
- Gascon J, Corachan M, Ramirez J. 5 cases of cysticercosis in Rwanda. Med Trop (Mars). 1989;49(1):77.Google Scholar
- Nguekam, Zoli AP, Ongolo-Zogo P, Dorny P, Brandt J, Geerts S. Follow-up of neurocysticercosis patients after treatment using an antigen detection ELISA. Parasite. 2003;10(1):65–8.PubMedGoogle Scholar
- Nguekam JP, Zoli AP, Zogo PO, Kamga ACT, Speybroeck N, Dorny P, et al. A seroepidemiological study of human cysticercosis in West Cameroon. Trop Med Int Health. 2003;8(2):144–9.PubMedGoogle Scholar
- Nkouawa A, Sako Y, Itoh S, Kouojip-Mabou A, Nganou CN, Saijo Y, et al. Serological studies of neurologic helminthic infections in rural areas of southwest Cameroon: toxocariasis, cysticercosis and paragonimiasis. Plos Negl Trop Dis. 2010;4(7):e732.PubMed CentralPubMedGoogle Scholar
- Zoli AP, Nguekam A, Shey-Njila O, Nforninwe DN, Speybroeek N, Ito A, et al. Neurocysticercosis and epilepsy in Cameroon. Trans R Soc Trop Med Hyg. 2003;97(6):683–6.PubMedGoogle Scholar
- Druet-Cabanac M, Preux PM, Bouteille B, Bernet-Bernady P, Dunand J, Hopkins A, et al. Onchocerciasis and epilepsy: A matched case–control study in the Central African Republic. Am J Epidemiol. 1999;149(6):565–70.PubMedGoogle Scholar
- Chartier C, Mutesi U, Ndakala N. Les helminthes du porc domestique en Ituri, haut Zaïre. In: Annales de la société belge de médecine tropicale. 1990. p. 213–25.Google Scholar
- Praet N, Kanobana K, Kabwe C, Maketa V, Lukanu P, Lutumba P, et al. Taenia solium Cysticercosis in the Democratic Republic of Congo: How does pork trade affect the transmission of the parasite? Plos Negl Trop Dis. 2010;4:9.Google Scholar
- Haridy FM, Ibrahim BB, Morsy TA, Ramadan NII. Human taenaisis and cysticercosis in slaughtered cattle, buffaloes and pigs in Egypt. J Egypt Soc Parasitol. 1999;29(2):375–94.PubMedGoogle Scholar
- Okome-Nkoumou M, Ondounda M, Dzeing-Ella A, Mounguengui D, Nziengui Madjinou M, Magne C, et al. Epileptiform seizures revealing neurocysticercosis: report of two clinical cases in Libreville, Gabon. Asian Pac J Trop Med. 2010;3(8):671–2.Google Scholar
- Secka A, Marcotty T, De Deken R, Van Marck E, Geerts S. Porcine cysticercosis and risk factors in The Gambia and Senegal. J Parasitol Res. 2010;2010:823892.PubMed CentralPubMedGoogle Scholar
- Permin A, Yelifari L, Bloch P, Steenhard N, Hansen NP, Nansen P. Parasites in cross-bred pigs in the Upper East Region of Ghana. Vet Parasitol. 1999;87(1):63–71.PubMedGoogle Scholar
- Ngugi AK, Bottomley C, Kleinschmidt I, Wagner RG, Kakooza-Mwesige A, Ae-Ngibise K, et al. Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case–control studies. Lancet Neurol. 2013;12(3):253–63.PubMed CentralPubMedGoogle Scholar
- Pampiglione S, Ricciardi ML, Visconti S, Branca A, Olivieri E, Zamberletti A. Ricerche sui parassiti intestinali dell’uomo in Africa subsahariana. 1. Boe Orientale e Isola de Canhabaque (Guinea-Bissau). Parassitologia. 1987;29(1):1–13.PubMedGoogle Scholar
- Carstensen H, Hansen HL, Kristiansen HO, Gomme G. The epidemiology of cryptosporidiosis and other intestinal parasitoses in children in southern Guinea-Bissau. Trans R Soc Trop Med Hyg. 1987;81(5):860–4.PubMedGoogle Scholar
- Githigia S, Murekefu A, Otieno R. Prevalence of porcine cysticercosis and risk factors for Taenia solium taeniosis in Funyula Division of Busia District, Kenya. Kenya Veterinarian. 2007;29(1):37–9.Google Scholar
- Kagira JM, Maingi N, Kanyari PWN, Githigia SM, Ng'ang'a JC, Gachohi JM. Seroprevalence of Cysticercus cellulosae and associated risk factors in free-range pigs in Kenya. J Helminthol. 2010;84(4):398–403.PubMedGoogle Scholar
- Mutua FK, Randolph TF, Arimi SM, Kitala PM, Githigia SM, Willingham AL, et al. Palpable lingual cysts, a possible indicator of porcine cysticercosis, in Teso District, Western Kenya. J Swine Health Prod. 2007;15(4):206.Google Scholar
- Waruingi M, Ramanankandrasana B, Druet-Cabanac M, Nsengiyumva G, Bouteille B, Preux P. Kenya: a new human cysticercosis focus. Afr J Neurol Sci. 2002;21:46.Google Scholar
- Michelet L, Carod J-F, Rakontondrazaka M, Ma L, Gay F, Dauga C. The pig tapeworm Taenia solium, the cause of cysticercosis: Biogeographic (temporal and spacial) origins in Madagascar. Mol Phylogenet Evol. 2010;55(2):744–50.PubMedGoogle Scholar
- Ramahefarisoa RM, Rakotondrazaka M, Jambou R, Carod JF. Comparison of ELISA and PCR assays for the diagnosis of porcine cysticercosis. Vet Parasitol. 2010;173(3–4):336–9.PubMedGoogle Scholar
- Yanagida T, Carod JF, Sako Y, Nakao M, Hoberg EP, Ito A. Genetics of the pig tapeworm in madagascar reveal a history of human dispersal and colonization. PLoS One. 2014;9(10), e109002.PubMed CentralPubMedGoogle Scholar
- Buchy P. Intestinal parasitoses in the Mahajanga region, west coast of Madagascar. Bull Soc Pathol Exo. 2003;96(1):41–5.Google Scholar
- Andriantsimahavandy A, Lesbordes JL, Rasoaharimalala B, Peghini M, Rabarijaona L, Roux J, et al. Neurocysticercosis: A major aetiological factor of late-onset epilepsy in Madagascar. Trop Med Int Health. 1997;2(8):741–6.PubMedGoogle Scholar
- Barba G, Doireau V, Lippa A, Tauzin C, Mensire A, Choulot JJ, et al. Cas radiologique du mois. Arch Pediatr. 1999;6(3):315–6.PubMedGoogle Scholar
- Bernardin P, Auzemery A, Rabenantoandro C. La cysticercose oculaire (C.O.) a Madagascar (a propos de 6 cas). Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1994;71:103–13.PubMedGoogle Scholar
- Grill J, Rakotomalala W, Andriantsimahavandy A, Boisier P, Guyon P, Roux J, et al. High prevalence of serological markers of cysticercosis among epileptic Malagasy children. Ann Trop Paediatr. 1996;16(3):185–91.PubMedGoogle Scholar
- Michel P, Callies P, Raharison H, Guyon P, Holvoet L, Genin C. Epidemiology of cysticercosis in Madagascar. Bull Soc Pathol Exo. 1993;86(1):62.Google Scholar
- Migliani R, Rasolomaharo M, Rajaonarison P, Ravaoalimalala V, Rabarijaona L, Andriantsimahavandy A. La cysticercose dans le port de Mahajanga: plus fréquente qu'on ne l'imagine! Arch Inst Pasteur Madagascar. 2000;66(1–2):39–42.PubMedGoogle Scholar
- Kumwenda JJ, Mateyu G, Kampondeni S, van Dam AP, van Lieshout L, Zijlstra EE. Differential diagnosis of stroke in a setting of high HIV prevalence in Blantyre, Malawi. Stroke. 2005;36(5):960–4.PubMedGoogle Scholar
- Maïga Y, Diallo M, Bouteille B, Konate A, Diarra M, Maïga M, et al. Àpropos d’un cas autochtone de neurocysticercose au Mali (premier cas de la littérature?). Bull Soc Pathol Exo. 2009;102(4):211–4.Google Scholar
- Matos C, Sitoe C, Afonso S, Banze J, Baptista J, Dias G, et al. A pilot study of common health problems in smallholder pigs in Angónia and Boane districts, Mozambique. J S Afr Vet Assoc. 2011;82(3):166–9.PubMedGoogle Scholar
- Pondja A, Neves L, Mlangwa J, Afonso S, Fafetine J, Willingham AL, et al. Use of oxfendazole to control porcine cysticercosis in a high-endemic area of mozambique. Plos Negl Trop Dis. 2012;6(5):e1651.PubMed CentralPubMedGoogle Scholar
- Noormahomed EV, Pividal JG, Azzouz S, Mascaro C, Delgado-Rodriguez M, Osuna A. Seroprevalence of anti-cysticercus antibodies among the children living in the urban environs of Maputo, Mozambique. Ann Trop Med Parasitol. 2003;97(1):31–5.PubMedGoogle Scholar
- Noormahomed EV, Nhacupe N, Mascaró-Lazcano C, Mauaie MN, Buene T, Funzamo CA, et al. A cross-sectional serological study of cysticercosis, schistosomiasis, toxocariasis and echinococcosis in HIV-1 infected people in Beira, Mozambique. Plos Negl Trop Dis. 2014;8(9), e3121.PubMed CentralPubMedGoogle Scholar
- Vilhena M, Santos M, Torgal J. Seroprevalence of human cysticercosis in Maputo, Mozambique. Am J Trop Med Hyg. 1999;61(1):59–62.PubMedGoogle Scholar
- Biu AA, Ijudai J. Prevalence and morphometric studies on porcine cysticercosis in Adamawa State, Nigeria. Sokoto J Vet Sci. 2012;10(1):28–31.Google Scholar
- Gweba M, Faleke OO, Junaidu AU, Fabiyi JP, Fajinmi AO. Some risk factors for Taenia solium cysticercosis in semi-intensively raised pigs in Zuru, Nigeria. Vet Ital. 2010;46(1):57–67.PubMedGoogle Scholar
- Karshima N, Bobbo A, Udokainyang A, Salihu A. Taenia Solium Cysticercosis in pigs slaughtered in IBI local government area of Taraba State, Nigeria. J Anim Sci Adv. 2013;3(3):109–13.Google Scholar
- Oladele SB, Ibrahim NDG, Fatihu MY, Mohammed B, Sambo SJ, Aluko RK. Twenty six years retrospective studies of the prevalence of gastrointestinal helminths isolated from necropsied animals in Zaria, Nigeria. Bull Epizoot Dis Afr. 2006;54(4):234–40.Google Scholar
- Onah DN, Chiejina SN. Taenia soluim cysticercosis and human taeniasis in the Nsukka area of Enugu State, Nigeria. Ann Trop Med Parasitol. 1995;89(4):399–407.PubMedGoogle Scholar
- Agbolade OM, Agu NC, Adesanya OO, Odejayi AO, Adigun AA, Adesanlu EB, et al. Intestinal helminthiases and schistosomiasis among school children in an urban center and some rural communities in southwest Nigeria. Korean J Parasitol. 2007;45(3):233–8.PubMed CentralPubMedGoogle Scholar
- Akogun OB. Some social aspects of helminthiasis among the people of Gumau District, Bauchi State, Nigeria. J Trop Med Hyg. 1989;92(3):193–6.PubMedGoogle Scholar
- Ekpo UF, Odoemene SN, Mafiana CF, Sam-Wobo SO. Helminthiasis and hygiene conditions of schools in Ikenne, Ogun State, Nigeria. PLoS Negl Trop Dis. 2008;2(1):e146.PubMed CentralPubMedGoogle Scholar
- Ojurongbe O, Raji OA, Akindele AA, Kareem MI, Adefioye OA, Adeyeba AO. Cryptosporidium and other enteric parasitic infections in HIV-seropositive individuals with and without diarrhoea in Osogbo, Nigeria. Br J Biomed Sci. 2011;68(2):75–8.PubMedGoogle Scholar
- Kanu I, Anyanwu EC, Nwachukwu NC, Ehiri JE, Merrick J. Clinical microbiological aspects of epileptic seizures in the tropical countries with specific focus on Nigeria. Sci World J. 2005;5:401–9.Google Scholar
- Omonisi AE, Odujoko OO, Aluko JA, Akinyemi HA, Alatishe OI, Omoniyi-Esan GO. Human cysticercosis of the breast mimicking breast cancer: a report of a case from Ile-Ife, Nigeria. Niger J Med. 2014;23(4):351–4.Google Scholar
- Rottbeck R, Nshimiyimana JF, Tugirimana P, Dull UE, Sattler J, Hategekimana JC, et al. High prevalence of cysticercosis in people with epilepsy in southern rwanda. Plos Negl Trop Dis. 2013;7(11):e2558.PubMed CentralPubMedGoogle Scholar
- Ndiaye D, Ndiaye M, Gueye PA, Badiane A, Fall ID, Ndiaye YD, et al. Intestinal helminthiasis diagnosed in Dakar, Senegal. Med Sante Trop. 2013;23(1):35–8.PubMedGoogle Scholar
- Secka A, Grimm F, Marcotty T, Geysen D, Niang AM, Ngale V, et al. Old focus of cysticercosis in a senegalese village revisited after half a century. Acta Trop. 2011;119(2–3):199–202.PubMedGoogle Scholar
- Pammenter M, Rossouw E, Dingle C. Serological detection of cysticercosis in two rural areas of South Africa. Trans R Soc Trop Med Hyg. 1987;81(2):242–4.PubMedGoogle Scholar
- Tronnberg L, Hawksworth D, Hansen A, Archer C, Stenstrom TA. Household-based prevalence of helminths and parasitic protozoa in rural KwaZulu-Natal, South Africa, assessed from faecal vault sampling. Trans R Soc Trop Med Hyg. 2010;104(10):646–52.PubMedGoogle Scholar
- Foyaca-Sibat H, Cowan LD, Carabin H, Targonska I, Anwary MA, Serrano-Ocana G, et al. Accuracy of serological testing for the diagnosis of prevalent neurocysticercosis in outpatients with epilepsy, Eastern Cape Province, South Africa. PLoS Negl Trop Dis. 2009;3(12), e562.PubMed CentralPubMedGoogle Scholar
- Mafojane NA. The neurocysticercosis project in Atteridgeville-Mamelodi townships. S Afr Med J. 1994;84:208–11.PubMedGoogle Scholar
- Naidoo D, Pammenter M, Moosa A, Van Dellen J, Cosnett J. Seventy black epileptics. Cysticercosis, computed tomography and electro-encephalography. S Afr Med J. 1987;72(12):837–8.PubMedGoogle Scholar
- Sacks LV, Berkowitz I. Cysticercosis in an urban black South African community: prevalence and risk factors. Trop Gastroenterol. 1990;11(1):30–3.PubMedGoogle Scholar
- Shasha W, Pammenter M. Sero-epidemiological studies of cysticercosis in school children from two rural areas of Transkei, South Africa. Ann Trop Med Parasitol. 1991;85(3):349–55.PubMedGoogle Scholar
- van As AD, Joubert J. Neurocysticercosis in 578 black epileptic patients. S Afr Med J. 1991;80(7):327–8.PubMedGoogle Scholar
- Boa ME, Mahundi EA, Kassuku AA, Willingham AL, Kyvsgaard NC. Epidemiological survey of swine cysticercosis using ante-mortem and post-mortem examination tests in the southern highlands of Tanzania. Vet Parasitol. 2006;139(1–3):249–55.PubMedGoogle Scholar
- Boa ME, Bogh HO, Kassuku AA, Nansen P. The prevalence of Taenia solium metacestodes in pigs in northern Tanzania. J Helminthol. 1995;69(2):113–7.Google Scholar
- Boa ME, Kassuku AA, Willingham AL, Keyyu JD, Phiri IK, Nansen P. Distribution and density of cysticerci of Taenia solium by muscle groups and organs in naturally infected local finished pigs in Tanzania. Vet Parasitol. 2002;106(2):155–64.PubMedGoogle Scholar
- Braae UC, Magnussen P, Lekule F, Harrison W, Johansen MV. Temporal fluctuations in the sero-prevalence of Taenia solium cysticercosis in pigs in Mbeya Region, Tanzania. Parasit Vectors. 2014;7(1):574.PubMed CentralPubMedGoogle Scholar
- Mkupasi E, Ngowi H, Sikasunge C, Leifsson P, Johansen M. Distribution and histopathological changes induced by cysts of Taenia solium in the brain of pigs from Tanzania. J Helminthol. 2014;1–6.Google Scholar
- Mkupasi EM, Ngowi HA, Sikasunge CS, Leifsson PS, Johansen MV. Efficacy of ivermectin and oxfendazole against Taenia solium cysticercosis and other parasitoses in naturally infected pigs. Acta Trop. 2013;128(1):48–53.PubMedGoogle Scholar
- Ngowi HA, Carabin H, Kassuku AA, Mlozi MRS, Mlangwa JED, Willingham AL. A health-education intervention trial to reduce porcine cysticercosis in Mbulu District, Tanzania. Prev Vet Med. 2008;85(1–2):52–67.PubMedGoogle Scholar
- Ngowi HA, Kassuku AA, Maeda GEM, Boa ME, Willingham AL. A slaughter slab survey for extra-intestinal porcine helminth infections in northern Tanzania. Trop Anim Health Pro. 2004;36(4):335–40.Google Scholar
- Ngowi HA, Kassuku AA, Maeda GEM, Boa ME, Carabin H, Willingham AL. Risk factors for the prevalence of porcine cysticercosis in Mbulu District, Tanzania. Vet Parasitol. 2004;120(4):275–83.PubMedGoogle Scholar
- Yohana C, Mwita CJ, Nkwengulila G. The prevalence of porcine cysticercosis and risk factors for taeniasis in Iringa rural district. Int J Anim Vet Adv. 2013;5(6):251–5.Google Scholar
- Eom KS, Chai J-Y, Yong T-S, Min D-Y, Rim H-J, Kihamia C, et al. Morphologic and Genetic Identification of Taenia Tapeworms in Tanzania and DNA Genotyping of Taenia solium. Korean J Parasitol. 2011;49(4):399–403.PubMed CentralPubMedGoogle Scholar
- Blocher J, Schmutzhard E, Wilkins PP, Gupton PN, Schaffert M, Auer H, et al. A cross-sectional study of people with Epilepsy and Neurocysticercosis in Tanzania: Clinical characteristics and diagnostic approaches. Plos Negl Trop Dis. 2011;5(6):e1185.PubMed CentralPubMedGoogle Scholar
- Mwang’onde BJ, Nkwengulila G, Chacha M. The serological survey for human cysticercosis prevalence in Mbulu District, Tanzania. Adv Infect Dis. 2012;2:62.Google Scholar
- Mwang’onde BJ, Nkwengulila G, Chacha M. The risk factors for human cysticercosis in Mbulu District, Tanzania. Onderstepoort J Vet Res. 2014;81(2):5.Google Scholar
- Winkler AS, Blocher J, Auer H, Gotwald T, Matuja W, Schmutzhard E. Anticysticercal and antitoxocaral antibodies in people with epilepsy in rural Tanzania. Trans R Soc Trop Med Hyg. 2008;102(10):1032–8.PubMedGoogle Scholar
- Winkler AS, Blocher J, Auer H, Gotwald T, Matuja W, Schmutzhard E. Epilepsy and neurocysticercosis in rural Tanzania—an imaging study. Epilepsia. 2009;50(5):987–93.PubMedGoogle Scholar
- Dumas M, Grunitzky K, Belo M, Dabis F, Deniau M, Bouteille B, et al. Cysticercose et neurocysticercose: enquête épidémiologique dans le nord du Togo. Bull Soc Pathol Exo. 1990;83(2):263–74.Google Scholar
- Balogou A, Grunitzky K, Beketi K, Bouteille B, Dumas M. Cysticercosis and epilepsy in the city of Tone, north of Togo. Rev Neurol (Paris). 2000;156(3):270–3.Google Scholar
- Belo M, Grunitzky EK, Balogou A, Kowu L. Cysticercose cérébrale et céphalées chez une jeune femme togolaise. Rev Neurol (Paris). 2001;157(4):433.Google Scholar
- Dumas M, Grunitzky E, Deniau M, Dabis F, Bouteille B, Belo M, et al. Epidemiological study of nuerocysticercosis in northern Togo West Africa. Acta Leiden. 1989;57(2):191–6.PubMedGoogle Scholar
- Grunitzky E, Balogou AK, M’Bella M, Mofou B, Sadzo A, Bouteille B, et al. La cysticercose chez des malades neurologiques en milieu hospitalier à Lomé, Togo. Ann Med Interne (Paris). 1995;146(6):419–22.Google Scholar
- Anyanzo T. Prevalence of Cysticercosis cellulosae in three sub-counties of Moyo County, Moyo District, Uganda. In: Bachelor of Veterinary Medicine Special Project Report, Faculty of Medicine, Makerere University, Kampala, Uganda. 1999.Google Scholar
- Kisakye J, Masaba S. Cysticercus cellulosae in pigs slaughtered in and around Kampala City. Ug J Agric Sci. 2002;7:23–4.Google Scholar
- Nsadha Z, Thomas LF, Fèvre EM, Nasinyama G, Ojok L, Waiswa C. Prevalence of porcine cysticercosis in the Lake Kyoga Basin, Uganda. BMC Vet Res. 2014;10(1):239.PubMed CentralPubMedGoogle Scholar
- Nsadha Z, Saimo M, Waiswa C, Ojok L, Willingham A, Mutagwanya R, et al. Risk factors and lingual prevalence of porcine cysticercosis in the Lake Kyoga Basin in Uganda. Afri J Anim Biomed Sci. 2010;5(3):43–50.Google Scholar
- Nsadha Z, Saimo M, Waiswa C, Nabwire I, Nkwole A, Sikasunge C, et al. Trans-boundary porcine cysticercosis a possibility on Uganda’s boarders. Afri J Anim Biomed Sci. 2011;6(1):67–71.Google Scholar
- Waiswa C, Fevre EM, Nsadha Z, Sikasunge CS, Willingham AL. Porcine cysticercosis in southeast Uganda: seroprevalence in kamuli and kaliro districts. J Parasitol Res. 2009;2009.Google Scholar
- Kabatereine NB, Kemijumbi J, Kazibwe F, Onapa AW. Human intestinal parasites in primary school children in Kampala, Uganda. East Afr Med J. 1997;74(5):311–4.PubMedGoogle Scholar
- Katabarwa M, Lakwo T, Habumogisha P, Richards F, Eberhard M. Could neurocysticercosis be the cause of “onchocerciasis-associated” epileptic seizures? Am J Trop Med Hyg. 2008;78(3):400–1.PubMedGoogle Scholar
- Phiri I, Dorny P, Gabriël S, Willingham AL, Sikasunge C, Siziya S, et al. Assessment of routine inspection methods for porcine cysticercosis in Zambian village pigs. J Helminthol. 2006;80(1):69–72.PubMedGoogle Scholar
- Phiri IK, Dorny P, Gabriel S, Willingham AL, Speybroeck N, Vercruysse J. The prevalence of porcine cysticercosis in Eastern and Southern provinces of Zambia. Vet Parasitol. 2002;108(1):31–9.PubMedGoogle Scholar
- Sikasunge CS, Phiri IK, Phiri AM, Siziya S, Dorny P, Willingham III AL. Prevalence of Taenia solium porcine cysticercosis in the Eastern, Southern and Western provinces of Zambia. Vet J. 2008;176(2):240–4.PubMedGoogle Scholar
- Mwape KE, Phiri IK, Praet N, Speybroeck N, Muma JB, Dorny P, et al. The incidence of human cysticercosis in a rural community of Eastern Zambia. Plos Negl Trop Dis. 2013;7(3):e2142.PubMed CentralPubMedGoogle Scholar
- Mwape KE, Phiri IK, Praet N, Dorny P, Muma JB, Zulu G, et al. Study and ranking of determinants of Taenia solium infections by classification tree models. Am J Trop Med Hyg. 2015;92(1):56–63.PubMedGoogle Scholar
- Siwila J, Phiri IG, Enemark HL, Nchito M, Olsen A. Intestinal helminths and protozoa in children in pre-schools in Kafue district, Zambia. Trans R Soc Trop Med Hyg. 2010;104(2):122–8.PubMedGoogle Scholar
- Cortnum S, Knudsen KB, Sorensen P. Kirurgisk behandling af neurocysticerkose hos et 12-årigt barn. Ugeskr Laeger. 2011;173(36):2203–4.PubMedGoogle Scholar
- Mwape KE, Praet N, Benitez-Ortiz W, Muma JB, Zulu G, Celi-Erazo M, et al. Field evaluation of urine antigen detection for diagnosis of Taenia solium cysticercosis. Trans R Soc Trop Med Hyg. 2011;105(10):574–8.PubMedGoogle Scholar
- Matenga E, Mukaratirwa S, Willingham A. Prevalence of porcine cysticercosis and hydatidosis in slaughtered animals in southwestern Zimbabwe: a retrospective study. In: Proceedings of the 11th Annual Meeting of ENRECA Livestock Helminths Research Project in Eastern and Southern Africa, 6–9 June 2002. 2002.Google Scholar
- Baily GG, Levy LF. Racemose cysticercosis treated with praziquantel. Trans R Soc Trop Med Hyg. 1989;83(1):95–6.PubMedGoogle Scholar
- Mason P, Houston S, Gwanzura L. Neurocysticercosis: experience with diagnosis by ELISA serology and computerized tomography in Zimbabwe. Cent Afr J Med. 1992;38(4):149–54.PubMedGoogle Scholar
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