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Table 1 Data on the 14 dogs enrolled in the study at T0

From: Effect of domperidone (leisguard®) on antibody titers, inflammatory markers and creatinine in dogs with leishmaniosis and chronic kidney disease

Dog ID no.

Inclusion (T0)

IRIS stage/NP, BP, Pb

Creatinine (mg/dl) RI: 0.70–1.40

UPCb

Leishmania infantum ELISA (%)c

Globulins (g/dl) RI: 2.8–3.9

CRP (mg/dl) RI: 0.01–0.45

Big ET-1 (pg/ml)

1a

1/BP

1.07

0.21

Low (18.3)

4.1

0.16

2.4

2a

1/P

0.84

1.27

Medium (20.8)

3.6

0.05

2.1

3

1/P

0.74

4.5

High (33.9)

3.4

0.08

3.0

4

1/P

0.95

0.54

Low (14.7)

2.9

0.69

2.0

5a

1/P

0.55

1.69

Low (14.8)

3.1

0.03

NA

6

1/BP

1.12

0.23

High (32.0)

4.5

0.09

1.8

7

1/P

1.00

1.21

Medium (22.3)

3.8

0.29

1.6

8

2/P

2.37

1.74

High (30.5)

4.0

0.24

NA

9

1/BP

0.60

0.41

Medium (24.7)

4.0

0.41

1.8

10a

1/P

1.20

2.07

Low (17.5)

3.7

0.02

2.0

11

1/BP

1.12

0.21

Low (18.1)

4.3

0.19

1.9

12

1/BP

1.22

0.33

High (31.2)

4.5

0.12

1.8

13

1/P

1.10

0.60

Low (18.6)

4.1

0.32

NA

14a

1/BP

0.60

0.41

High (29.5)

4.0

0.41

2.1

  1. All dogs were receiving treatment for chronic kidney disease for > 6 months
  2. Big ET-1 Big endothelin-1, CRP C-reactive protein, ELISA enzyme-linked immuosorbent assay, NA not applicable, RI reference interval, T0 inclusion time point, UPC urinary protein/creatinine ratio
  3. aDogs excluded from the study at different time points
  4. bIRIS stages: 1–4. NP, Non-proteinuric (UPC < 0.20); BP, borderline proteinuric (UPC = 0.21–0.50); P, proteinuric (UPC > 0.50) [31]
  5. cLow 13–20%; medium 20.1–25%; high > 25%
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