Immunological and genomic characterization of Ibizan Hound dogs in an endemic Leishmania infantum region

Parasites & Vectors

Table 3 Genomic variants found in genes encoding analyzed cytokines and their receptors

Gene encodes cytokine, receptor, or gene related¹	rsID	Chromosome position	Ref.–alt.²	Frequency	Functional class of variant
IFN-γ (IFNG)	rs22078594	10:10,408,724	G-A	0.86	Intronic
IL-2 (IL2)	rs22707631	19: 17,756,202	T-C	0.63	3′UTR
IL-6 receptor (IL6R)	rs24423644	7: 42,878,605	C-T	1.00	3′UTR
	rs24416159	7: 42,902,063	G-A	0.78	Intronic
	rs24433326	7: 42,888,754	T-C	0.22	Intronic
IL-6 cytokine family signal transducer (IL6ST) gene	rs22868191	2:43,260,700	T-C	0.15	Intronic

Table shows the variant identification (rsID), chromosome position, reference and alternative alleles, frequency of alternative variant in the analyzed samples (those with frequencies > 0.7 are highlighted in bold) and functional class of variant
¹IFN- γ: interferon gamma, IL: interleukin
²C: cytosine, T: thymine; A: adenine; G: guanine

ISSN: 1756-3305