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Dogs, cats, parasites, and humans in Brazil: opening the black box

  • The Erratum to this article has been published in Parasites & Vectors 2016 9:298


Dogs and cats in Brazil serve as primary hosts for a considerable number of parasites, which may affect their health and wellbeing. These may include endoparasites (e.g., protozoa, cestodes, trematodes, and nematodes) and ectoparasites (i.e., fleas, lice, mites, and ticks). While some dog and cat parasites are highly host-specific (e.g., Aelurostrongylus abstrusus and Felicola subrostratus for cats, and Angiostrongylus vasorum and Trichodectes canis for dogs), others may easily switch to other hosts, including humans. In fact, several dog and cat parasites (e.g., Toxoplasma gondii, Dipylidium caninum, Ancylostoma caninum, Strongyloides stercoralis, and Toxocara canis) are important not only from a veterinary perspective but also from a medical standpoint. In addition, some of them (e.g., Lynxacarus radovskyi on cats and Rangelia vitalii in dogs) are little known to most veterinary practitioners working in Brazil. This article is a compendium on dog and cat parasites in Brazil and a call for a One Health approach towards a better management of some of these parasites, which may potentially affect humans. Practical aspects related to the diagnosis, treatment, and control of parasitic diseases of dogs and cats in Brazil are discussed.

Portuguese version

Please see Additional file 1 ( for the Portuguese version of this review article.


The word “parasite” (from Ancient Greek, parasitos: para = beside, sitos = food) means literally a person that eats at the table of another. In the figurative sense, corrupt politicians that make the use their political power and public resources for their own benefit may be called parasites of society. But in parasitology, a parasite is an organism that takes benefit from another (the host), without giving something back and usually causing some damage to it. Incidentally, parasites constitute a diverse group of organisms that may affect a wide range of animal hosts, including amphibians, birds, fishes, mammals, and reptiles. They may be generally subdivided as endoparasites (=internal) and ectoparasites (=external), according to their location in the host. Ectoparasites may also be classified as permanent (e.g., lice and mites) or non-permanent (e.g., ticks and mosquitoes), depending on the relationship with their host; i.e., whether their life cycle takes place solely on their hosts or also in the environment.

Dogs and cats are the most popular pet animals worldwide. Nowadays, dogs for example have assumed many functions as guides for blind people, as therapeutic agents, as guard and hunting dogs. Moreover, in many developing countries, both dogs and cats have become part of human families, regardless of the social class (Figure 1). The benefits of having a pet animal are undisputed [1], but both dogs and cats may harbour many parasites potentially transmissible to humans, which may represent a health risk, especially to children, the elderly and the immunocompromised [2]. For instance, Toxoplasma gondii, Dipylidium caninum, Echinococcus granulosus, Ancylostoma braziliense, Toxocara canis, Onchocerca lupi, and Thelazia callipaeda are common parasites of dogs and cats that can affect humans in different countries around the world. This fact emphasizes the need for a One Health approach towards a more efficient management and control of these parasites [3, 4].

Figure 1

Human-animal bond. A homeless with his inseparable friends that were found abandoned in the streets of Porto Alegre, southern Brazil.

At the beginning of the 21st century, parasitic diseases are still causing a severe burden on animal and human populations in tropical and subtropical regions around the world [57]. Furthermore, the impact of some of these diseases is disproportionally higher in developing countries such as Brazil, because the living conditions of the populations often favour the exposure to certain parasites, whose transmission may be associated with poor housing and sanitary conditions (Figure 2), as well as with inequities in the access to education and primary healthcare services.

Figure 2

Poor living conditions. An owner and his dogs living in a poor rural community in Goiana, north-eastern Brazil, where visceral leishmaniosis is endemic. In poor rural communities people (as this man in the picture) are used to walking barefoot, which is a risk factor for bare feet-related diseases, such as cutaneous larva migrans and tungiasis.

Brazil is a country with continental dimensions (i.e., 8,515,767 km2), occupying most of the land area of South America and representing the largest economy in the region. Despite the persistent social and economic inequalities (e.g., unequal access to education, health care and sanitation, safe drinking water and decent housing), which have become the dark side of the Brazilian history, the importance of dogs and cats as pets, as well as the demand for high standard veterinary services, has increased over the last decades in Brazil. Impressively, according to the Associação Brasileira da Indústria de Produtos para Animais de Estimação (Abinpet), Brazil currently holds the world’s second largest dog and cat populations, with over 37 million dogs and 21 million cats ( Apropos, the growing number of dogs and cats in urban areas in Brazil has been accompanied by substantial increases in the animal feed and pet care markets. According to Abinpet, the Brazilian pet market will earn 15.4 billion Brazilian real (approximately 7 billion US dollars) in 2013, with an overall increase of 8.3% in comparison with 2012. Specifically, it has been estimated that in 2013 the pet service sector (services related to animal care, including bath and hair cut) will increase in 24.5%, pet food (animal feed) in 4.9%, pet care (equipments, accessories and products for animal hygiene and care) in 5.2%, and pet vet (medicines) in 6.7%. These numbers pose Brazil as the world’s second largest pet market, behind only the United States.

The diversity of natural environments present in Brazil is outstanding, as is its biodiversity. By the bye, dogs and cats living in Brazil may harbour a long list of parasites that may affect their wellbeing and eventually pose a risk to the health of their owners [8, 9]. Information on their distribution, epidemiology, and impact on human health is fragmentary and mainly published in Brazilian journals. In this sense, this article is a compendium on dog and cat parasites in Brazil and a call for a One Health approach towards a better management of some of these parasites, which may potentially affect humans. Practical aspects related to the diagnosis, treatment, and control of parasitic diseases of dogs and cats in Brazil are discussed.


Ectoparasites of dogs and cats in Brazil

Ectoparasites may cause irritation, blood depletion, pruritus, and skin lesions, potentially leading to the occurrence of secondary bacterial infections. Some ectoparasites such as fleas, lice and ticks may also transmit pathogens to dogs and cats, including bacteria, protozoa, and helminths reviewed in Ref. [9]. Furthermore, ticks can also cause toxicosis, as it has recently been reported in a dog bitten by the mouro tick Ornithodoros brasiliensis in Brazil [10].

In Brazil, dogs and cats may serve as hosts for a large number of ectoparasites, including fleas, lice, mites, and ticks (Tables 1 and 2). Indeed, dogs may be frequently infested by species of fleas (e.g., Ctenocephalides canis, Ctenocephalides felis felis, and Tunga penetrans), lice (e.g., Heterodoxus spiniger and Trichodectes canis), mites (e.g., Demodex canis, Otodectes cynotis, and Sarcoptes scabiei) and ticks (e.g., Amblyomma aureolatum, Amblyomma ovale, and Rhipicephalus sanguineus sensu lato) [1141]. While some flea species may be common in rural settings (e.g., T. penetrans), C. felis felis is indeed the most common flea infesting dogs in Brazil. Other less common ectoparasites (e.g., the flea Rhopalopsyllus lutzi lutzi) have also been reported in dogs in Brazil [21, 28]. In a similar manner, the findings of some wildlife-associated ticks (e.g., Amblyomma longirostre, Amblyomma naponsense, Amblyomma nodosum, Amblyomma pacae, Amblyomma scalpturatum, and Haemaphysalis juxtakochi) on dogs in Brazil are incidental findings and of unknown clinical significance.

Table 1 Ectoparasites of dogs in Brazil
Table 2 Ectoparasites of cats in Brazil

Cats in Brazil are frequently found infested by fleas (e.g., C. canis, C. felis felis, P. irritans, and T. penetrans), lice (Felicola subrostratus), and mites (e.g., D. cati, Lynxacarus radovskyi, Notoedres cati, and O. cynotis) [19, 22, 4249]. Less frequently, they have been found infested by ticks such as R. sanguineus s.l. and Amblyomma triste[49, 50]. Some of these ectoparasites are well known in certain regions (e.g., L. radovskyi in north-eastern Brazil), but completely unknown or considered rare in others. Even if cats have more knowhow than dogs when the issue is “ectoparasite removal” by grooming, they may be highly exposed to ectoparasites, particularly in high-density situations such as in catteries [45].

Even if most fleas, lice, mites, and ticks infesting dogs and cats may be easily identified, the delineation of some species may be troublesome for non-taxonomists [51, 52]. While some keys for fleas, lice, and ticks have been published in books [13, 14, 53] and journals [5456], there are no comprehensive pictorial keys for the identification of dog and cat ectoparasites in Brazil (see Table 3 and Figure 3).

Table 3 Key for ectoparasites identification
Figure 3

Ectoparasites of dogs and cats. Line drawings for the identification of common dog and cat ectoparasites (fleas: A-F; lice: G-J and mites: K-P) found in Brazil. For details see Table 3).

Flying insects may also represent a significant clinical problem to dogs as cats in Brazil [9, 5766]. For instance, mosquitoes, phlebotomine sand flies and triatomine bugs are vectors of Dirofilaria immitis, Leishmania infantum, and Trypanosoma cruzi, respectively, to both dogs and cats [9]. Myiasis is also quite a common problem in dogs and cats in Brazil, being most frequently associated with infestation by larvae of Cochliomyia hominivorax and Dermatobia hominis [5865], and less commonly by other species of flies (e.g., Lucilia eximia) [57, 65]. Furthermore, stable flies (Stomoxys calcitrans) can produce skin lesions on the ears of these animals, which may also lead to the occurrence of secondary bacterial infections [9, 66].

Endoparasites of dogs and cats in Brazil

In addition to ectoparasites, dogs in Brazil may be affected by numerous endoparasites (Table 4), including protozoa, cestodes (tapeworms), trematodes (flukes), and nematodes (roundworms) [32, 67130]. For instance, endoparasites such as Dipylidium caninum, Echinococcus granulosus, A. braziliense, Ancylostoma caninum, Strongyloides stercoralis, Toxocara canis, Trichuris vulpis, and Dirofilaria immitis are commonly found in dogs from different Brazilian regions [67, 69]. Other endoparasites such as Angiostrongylus vasorum have only sporadically been reported in Brazil [74]. Similarly, cats have frequently been found affected by several endoparasites (Table 5) in Brazil, including T. gondii, D. caninum, Taenia taeniformis, Spirometra mansonoides, Aelurostrongylus abstrusus, A. braziliense, A. caninum, A. tubaeforme, Toxascaris leonina, Toxocara cati, Pearsonema feliscati, Trichuris campanula, Trichuris serrata, Physaloptera praeputialis, and Platynosomum fastosum [47, 71, 87, 90, 92, 97, 131137]. Less common endoparasites have also been reported in cats, such as the acanthocephalan Sphaerirostris erraticus [137].

Table 4 Endoparasites of dogs in Brazil
Table 5 Endoparasites of cats in Brazil

Dogs have been found infected by vector-borne protozoa, including Babesia gibsoni, Babesia vogeli, Rangelia vitalii, Hepatozoon canis, Leishmania amazonensis, Leishmania braziliensis, Leishmania infantum, Trypanosoma cruzi, and Trypanosoma evansi [73, 7882, 85, 8790, 96, 102104, 109113, 117121],[124, 128130]. Other protozoa of unknown pathogenicity (e.g., Trypanosoma caninum) have also been described in Brazilian dogs [108]. In addition, other vector-borne organisms have also been frequently reported in dogs, including Anaplasma platys, Ehrlichia canis and, less frequently, Rickettsia rickettsii [9].

Cats have also been found infected by vector-borne protozoa such as B. vogeli, Cytauxzoon felis, H. canis, Hepatozoon felis, L. amazonensis, L. braziliensis, and L. infantum [42, 44, 129, 136, 138148]. Indeed, the diversity of endoparasites of cats and dogs in Brazil is impressive, but certainly underestimated, mainly because most studies carried out in this country have been based on the detection and identification of eggs and oocysts in faecal samples using ordinary coprological techniques. This emphasizes the need for additional diagnostic methods (e.g., coproantigen tests, molecular tests or post-mortem examination) if we are to understand the actual diversity and prevalence of endoparasites of dogs and cats in Brazil.

Geographical distribution and prevalence

Dog and cat parasites are widespread in Brazil and in most cases occur virtually in all geographical regions (north, northeast, south, southeast, and centre-west) of the country. However, for several common external parasites (e.g., D. canis, N. cati e O. cynotis) and internal (e.g., D. caninum, A. brasiliense e T. canis) there is relatively limited published information, particularly in international journals. Therefore, it is presently difficult to generate informative, bona fide maps for most dog and cat parasites occurring in Brazil, even if most of these parasites are certainly present in all regions of the country. For instance, in a study carried out in south-eastern Brazil, 155 dogs were necropsied and D. caninum was diagnose in 57 (36.8%) of them, A. caninum in 30 (19.4%), and T. canis in 24 (15.5%) [36]. Similarly, a study conducted in north-eastern Brazil, revealed that A. caninum (prevalence, 95.7%) was the most prevalent endoparasite in 46 stray dogs necropsied, followed by D. caninum (45.7%), T. canis (8.7%), and T. vulpis (4.3%) [32]. These studies indicate high prevalence rates of infestation by endoparasites in stray dogs from different Brazilian regions representing a permanent source of endoparasites to pet animals and a major zoonotic hazard for humans, through the contamination of public parks and beaches (see “Dogs, cats, parasites and humans: public health aspects”).

Stray cats are also frequently exposed to endoparasites. For instance, a study conducted in south-eastern Brazil reported infestations by A. braziliense (67.3%), A. caninum (21.1%), and A. tubaeforme (9.6%) in 52 cats necropsied [116]. Similarly, in a recent study conducted in centre-western Brazil, 146 cats were necropsied and 98 of them were infested by roundworms [A. braziliense (50.68%); A. tubaeforme (10.27%); T. cati (4.11%); P. praeputialis (2.05%); P. feliscati (3.42%); and A. abstrusus (1.37%)], cestodes [S. mansonoides (4.11%); D. caninum (3.42%); and T. taeniformis (0.68%)], trematodes [P. fastosum (26.03%)], and acanthocephalans [S. erraticus (3.42%)] [137]. Again, these studies reveal a considerable diversity of endoparasites in cats from different Brazilian regions, with relatively high prevalence rates.

The geographical distribution of vector-borne protozoa and heminths of dogs has been reviewed elsewhere [9]. For instance, L. infantum is widespread in all Brazilian regions [81, 113, 149, 150], but less frequent in southern parts of the country [151, 152]. However, L. longipalpis, the principal vector for L. infantum, is present in northern Argentina [153], Paraguay [154], and has recently been detected in Uruguay [155]. Furthermore, L. longipalpis is abundant in Mato Grosso do Sul State [156], which makes border with Paraná State in southern Brazil. Last but not least, the presence of L. longipalpis in Rio Grande do Sul (the southernmost Brazilian state) has been proven [157]. These findings may suggest that L. longipalpis may have already colonized other areas of southern Brazil and that canine leishmaniosis may become a problem in that region in the near future.

The little known protozoan R. vitalii occurs mainly in southern and south-eastern Brazil [119, 124, 158, 159], where ticks such as A. aureolatum, the putative vector, are commonly found in dogs frequenting the Atlantic rainforest environment [160]. Interestingly, B. gibsoni has been reported exclusively in southern Brazil [87, 104], which also suggests that R. sanguineus s.l. is not the vector of this protozoan in Brazil, considering that this tick is prevalent in virtually all regions of the country [52, 161, 162]. In fact, pathogens that are transmitted by R. sanguineus s.l. (e.g., B. vogeli and Ehrlichia canis) are usually widespread in Brazil [9], not concentrated in a specific region as it occurs with B. gibsoni. In any case, the possibility that R. sanguineus s.l. ticks are acting as vectors of B. gibsoni in Brazil cannot be ruled out.

Ctenocephalides spp. fleas are also widespread in Brazil [18, 35, 36, 38, 129], but C. felis felis surpasses C. canis in distribution, the latter being reputed to be more common in regions with more temperate climates, as in the south-east and south of the country [51]. Indeed, C. felis felis has been reported in 17 states (Alagoas, Amazonas, Bahia, Ceará, Espírito Santo, Goiás, Mato Grosso, Minas Gerais, Paraíba, Paraná, Pernambuco, Rio de Janeiro, Rio Grande do Norte, Rio Grande do Sul, Roraima, Santa Catarina, and São Paulo), while C. canis has been reported in only nine (Amazonas, Bahia, Maranhão, Minas Gerais, Paraná, Pernambuco, Rio Grande do Sul, Santa Catarina, and São Paulo) [51]. As a consequence of the widespread distribution of Ctenocephalides spp. fleas on dogs and cats, flea-borne parasites like D. caninum and A. reconditum [163167] are widespread in Brazil as reviewed in Ref. [9].

Even if fleas, lice and ticks may be found infesting dogs in all Brazilian regions, the distribution and prevalence at the local level may vary widely, also according to climate conditions and the degree of urbanization of each area. For instance, in a study conducted in north-eastern Brazil, the frequency of infestation by R. sanguineus s.l. tended to be higher in urban than in rural areas, whereas infestations by Amblyomma ticks and C. felis felis was more common on rural dogs [39]. In the same study, mixed infestations were significantly more frequent on rural than on urban dogs. Nonetheless, even if R. sanguineus s.l. ticks are more prevalent in urban settings [18, 28, 32], they may infest a high proportion of rural dogs in some areas [30, 33, 36].

Serological surveys have also reported moderate to high levels of exposure to parasites such as Neospora caninum and T. gondii in dogs and cats in Brazil [151, 168173]. For instance, in a recent study carried out in south-eastern Brazil, 386 cats were assayed by indirect immunofluorescence antibody tests (IFAT) for the presence of antibodies against T. gondii and 63 (16.3%) of them were positive [172]. Prevalence rates of anti-N. caninum antibodies in dogs ranging from 26% to 34.5% were reported in north-eastern Brazil, with 57.6% of the seropositive dogs also being positive for anti-T. gondii antibodies [169]. In another study conducted in south-eastern Brazil, 703 dogs from urban and rural areas were tested for N. caninum and 11.4% of them were positive. The likelihood of being positive to N. caninum was associated with dogs aged >4 years, guard dogs, hunting dogs, and with dogs from dairy farms with a history of bovine abortion [173]. In particular, among rural dogs, an association with seroprevalence was recorded for milk farms, dogs not fed with commercial food, hunting, and guard dogs. Altogether, these studies reveal that dogs and cats from different regions both rural and urban areas are at risk of infection by parasites such as N. caninum and T. gondii. This is also true for Leishmania spp. in dogs, for which seroprevalence rates higher than 60% have been reported in some highly endemic areas [168].

Seasonal dynamics in the tropics

Information on the ecology of parasites of dogs and cats in Brazil is fragmentary, meagre, and, for several parasites, completely lacking. Considering the variety of biomes (Atlantic Rainforest, Amazon, Pantanal, Cerrado, Caatinga, and Pampa) and climates (from tropical north to temperate zones below the Tropic of Capricorn) registered in Brazil, the seasonal dynamics of dog and cat parasite populations would be expectedly variable from region to region. Nonetheless, the climate conditions in Brazil are so suitable that a range of arthropod vectors are found the year-round. For instance, studies carried out in an area of D. immitis endemicity in Rio de Janeiro indicated that mosquito vectors (e.g., Ochlerotatus scapularis and Ochlerotatus taeniorhynchus) are more abundant during summer months, but may also be captured in high number in winter months [174]. These findings suggest that dogs and cats may be at risk of D. immitis infestation during the whole year, especially because the average annual temperature in most of the Brazilian territory is between 21 and 30°C, which indeed facilitates the development of infective larvae (L3) in the mosquito vector.

The presence of ectoparasites during the whole year in Brazil is apparently the rule, not the exception. Phlebotomine sand fly vectors of Leishmania parasites such as L. longipalpis (Figure 4) and L. whitmani may be found in high numbers throughout the year in different Brazilian regions [175180], even if some species may display population peaks during the months of highest rainfall [181]. The same applies for fleas and ticks. A recent study developed in south-eastern Brazil revealed high prevalence rates of flea (C. felis felis) and tick (A. cajennense and R. sanguineus s.l.) infestations during the dry and rainy seasons [35]. Another study carried out in the same region indicated that R. sanguineus s.l. may infest dogs during any period of the year and completes three generations per year [182]. Similarly, an investigation conducted in centre-western Brazil suggested that this tick may complete up to four generations per year [183]. Again, these findings suggest that different Brazilian regions possess climate types and environmental conditions that enable the occurrence of ticks during all months of the year. For example, even if a study has identified variations in B. vogeli infection in dogs apparently associated with peaks in the tick vector population [184], evidence indicates that this protozoan may infect dogs at any period of the year in some regions, regardless of the season [120]. On the other hand, myiasis by C. hominivorax in dogs and cats presents a clearly defined seasonal pattern in Brazil, peaking during the hottest months of the year [5961, 65].

Figure 4

Vector density. Hundreds of phlebotomine sand flies (Lutzomyia longipalpis) on a chicken (A) that was resting on a tree trunk in Passira, north-eastern Brazil, where visceral leishmaniosis is endemic. (B) shows a close-up of the phlebotomine sand flies

Data concerning the seasonal dynamics of endoparasites in dogs and cats in Brazil is meagre. The incidence of hookworm-related cutaneous larva migrans is higher during the rainy season [185]. Interestingly, a study reported a marked peak in Ancylostoma eggs shedding in dog faeces during summer and autumn, suggesting that winter conditions in São Paulo (south-eastern Brazil) have a negative effect on hookworm transmission [74]. Another study concluded that the southern region of Brazil has favourable edaphic and climatic conditions for soil contaminants (e.g., Toxocara eggs) to persist year-round, even if the species diversity of parasites was lower in winter and the number of parasites lower in summer [186]. This is in agreement with studies carried out in other parts of South America. For instance, a study conducted in Mar del Plata, Argentina, reported a high prevalence of intestinal parasites of dogs throughout the year, with some seasonal variations according to the genus or species of parasite [187]. Hookworms (Ancylostoma spp.) were more prevalent in the summer-autumn period, ascarids (T. canis) in winter, whereas whipworms (T. vulpis) peaked in winter, spring and summer. Once again, these data demonstrate a high risk of parasite infestation in all seasons in this part of the Americas.

Diagnostic and management approaches

Diagnosis of parasitic diseases

The diagnosis of parasitic diseases affecting dogs and cats in Brazil is still predominately made by traditional methods. For instance, gastrointestinal parasites are usually detected by ordinary coprological techniques, such as Willis (flotation in saturated sodium chloride solution), Faust (zinc sulphate centrifugal flotation) and Hoffman-Pons-Janer (spontaneous faecal sedimentation in water) techniques [188, 189]. These methods may present low sensitivity in some instances and result in the underestimation of the real prevalence of some parasites, such as D. caninum [74, 77, 100, 188, 190], when compared with necropsy data e.g., [32]. A commercial assay for faecal concentration (namely, TF-test®) designed for detecting human intestinal parasites [191] has also been used for detecting helminth eggs, protozoan cysts and oocysts in canine faeces [190]. A comparative study revealed that the centrifugal flotation technique was more sensitive than centrifugal sedimentation and TF-test® in detecting Ancylostoma spp., T. canis, T. vulpis and Giardia in dog faeces [190]. Another study reported that the Willis technique was more efficient in detecting eggs of A. caninum and T. canis in dog faeces [188]. As a corollary, a more recent study showed that the Willis and the centrifugal flotation techniques performed better than the Hoffman-Pons-Janer technique for detecting Ancylostoma spp. in dog faeces [189]. Other methods have also been proposed, but apparently with no significant difference in terms of sensitivity, as compared with traditional methods [98]. The use of an enzyme linked immunosorbent assay (ELISA) for the detection E. granulosus coproantigen revealed high positivity rates (from 27.69 to 47.37%) in rural dogs from southern Brazil [192]. In the same way, PCR-based techniques have been used to detect endoparasites (heminths and protozoa) of dogs in Brazil e.g., [83, 126, 193, 194] but currently these methods are mostly restricted to research.

Blood-dwelling protozoan parasites (e.g., B. vogeli and H. canis) are usually diagnosed by examination of stained-blood smears under a light microscope, which may lack in sensitivity, particularly if blood samples are collected outside the acute phase of the infection [195]. Serological tests are widely used to assess exposure to pathogens, such as B. vogeli, Leishmania spp., N. caninum, and T. gondii [168, 169, 184, 196198]. The use of molecular tools for diagnosing protozoan parasites (e.g., B. vogeli, H. canis, and L. infantum) is becoming more and more popular, but it is still mostly restricted to research [121, 199204]. Indeed, current PCR protocols have shown a good level of concordance with parasitological methods [150]. Unfortunately, the costs of molecular tools are still prohibitive for most pet owners living in endemic areas and this severely impairs the diagnosis of diseases such as visceral and cutaneous leishmaniosis in dogs. Indeed, current serological tools cannot distinguish between L. braziliensis and L. infantum [113, 205]. This may have direct implications for veterinary practitioners in Brazil because seropositive dogs are usually eliminated as part of the control programme against human visceral leishmaniosis, whilst it has been demonstrated that many of these dogs are infected by L. braziliensis rather than L. infantum [113, 205, 206]. Indeed, the high diversity of parasites in Brazil may be a confounding factor for the diagnosis of some diseases in dogs and cats in this country. For instance, different Leishmania species have been reported in these animals in Brazil and the clinical picture is not always predictable. A recent report described a case of canine leishmaniosis by L. infantum in which the dog presented a skin ulcer that is typically found in dogs and humans infected by L. braziliensis [207]. Again, dogs infected by L. amazonensis generally display clinical signs commonly observed in dogs with visceral leishmaniosis [96, 117]. On the other hand, cats infected by L. amazonensis typically display a cutaneous disease that resembles sporotrichosis [141, 208]. It means that the same parasite may eventually induce different clinical diseases in dogs and cats, which emphasizes the need for a proper laboratory diagnosis to confirm the parasite species involved. This is also true for eggs of ascarids (Toxocara spp.), and taenids (Taenia spp. and Echinococcus spp.) found in dog faeces, which cannot be normally differentiated by light microscopy [209, 210]. Hookworm eggs are not easily distinguishable by morphology, but morphometric data suggests that they can be differentiated [211]. Nonetheless, the use of improved, specific diagnostic techniques is fundamental towards a better management of parasitic diseases of dogs and cats in Brazil.

Controlling dog and cat parasites

Veterinary practitioners working in Brazil are provided with a relatively vast repertory of tools to control parasites affecting dogs and cats. Nonetheless, the control of common parasites such as fleas and ticks may sometimes appear quite difficult, mainly when the available tools are not properly used or when veterinary practitioners do not possess basic knowledge on the bio-ecology of some of these parasites. In Brazil, there are no official guidelines for the control of ecto- and endoparasites of dogs and cats, such as those provided by European Scientific Counsel Companion Animal Parasites (ESCCAP: in Europe and the Companion Animal Parasite Council (CAPC: in the United States. These guidelines are fundamental to ensure the delivery of the latest scientific information on parasite control to veterinary practitioners.

Because lice and mites live in permanent association with their hosts, they are relatively easily controlled and, once eliminated, re-infestation only occurs following contact with other infested animals [212, 213]. As such, the control of louse infestations in dogs and cats is mostly based on the application of insecticides on infested animals, which may be available as collars, spot-on solutions, and sprays [214216]. Mites are also permanent ectoparasites, with some of them living in the fur (L. radovskyi), others in the outer ear canal (O. cynotis), hair follicles and sebaceous glands (D. canis and D. cati), or even in galleries burrowed under the epidermis (N. cati e and S. scabiei). The treatment may be systemic (e.g., oral selamectin for S. scabiei) or topic (e.g., amitraz dip for D. canis). For instance, the treatment of infestations by the cat fur mite (L. radovskyi) in Brazil has been successfully performed with weekly baths using a soap containing tetramethylthiuram monosulfide [217]. Similarly, a single subcutaneous injection of doramectin 1% (0.3 mg/kg) has been effective in treating dogs with sarcoptic mange and endoparasites as well [218]. However, the treatment of demodicosis in dogs may vary depending on case severity, animal age, and the presence of underlying conditions [219]. Indeed, most young dogs with juvenile-onset localized demodicosis will resolve spontaneously without treatment, whereas adult dogs with generalized demodicosis usually require aggressive therapy, for example, with amitraz dip every two weeks for several months [219]. Furthermore, an underlying disease or condition (e.g., cancer, hyperadrenocorticism, use of immunosuppressive drugs) should always be investigated and treated accordingly, especially in cases of demodicosis in adult dogs. It is clear that the treatment of mange in dogs and cats depends on several factors linked to the mite species involved and to the characteristics of each individual patient. Veterinary practitioners should use the products specifically labelled for mange treatment in dogs and cats in Brazil and strictly follow the manufacturer’s recommendations.

In contrast to mites and lice, ticks and fleas are non-permanent parasites [212] and therefore specimens found on dogs and cats may represent only a small proportion of the whole flea and tick population present in the environment where infested animals live. A vast repertory of products are available in the veterinary market in Brazil for controlling fleas and ticks on dogs and cats. Insecticides and acaricides with potent anti-feeding and fast killing effects, repellents, insect growth regulators, and juvenile hormone analogues are available as spot-on pipettes, collars, shampoos, and sprays [212, 220]. However, before deciding the best control strategy to be adopted, the veterinary practitioner should also investigate the presence and the abundance of fleas/ticks in the environment where the animal lives. Ticks tend to drop off during the night when the dog is sleeping [221]. Moreover, flea eggs are not sticky, falling from the animal’s fur in the environment along with adult flea faeces. Newly hatched larvae usually avoid sunlight and actively move deep into carpet fibres or under organic debris [222]. Vacuuming places frequented by pets (e.g., carpets, furniture cushions, rugs, or other substrata), with a vacuum cleaner as well as washing of pet bedding or bed linen frequented by pets will help in the removal of flea eggs and larvae [222]. Furthermore, the treatment of the indoor and outdoor environment with insecticides and acaricides may be required in some situations, such as in kennels and catteries with high levels of environment flea and tick infestation. Care should be taken when applying chemical products in the environment and it is advisable that pet owners consult with a veterinarian or licensed pest control specialist [222].

The chemical control of other arthropods (e.g., kissing bugs, mosquitoes, and phlebotomine sand flies) in the environment is more complex and should also be performed in conjunction with public health authorities. For example, because mosquito larvae and pupae are strictly associated with water collections (e.g., containers, deactivated swimming pools, abandoned tyres), their population may be reduced and sometimes eradicated locally by destroying their breeding sites or by using biological control agents, such as the Bacillus thuringiensis israelensis and fishes such as bettas (Betta splendens) and guppies (Poecilia reticulata) [223, 224]. The spraying of houses and animal shelters (e.g., chicken pen) with residual insecticides has long been recommended for controlling insect vectors, such as phlebotomine sand flies in Brazil [225, 226]. However, results indicate that an effective vector population control may be difficult to achieve and resistance to insecticides currently in use in Brazil has been documented [227, 228]. The use of insecticide-treated bed nets has also been proven to be effective in protecting humans against L. longipalpis bites [229], but this strategy is not currently used in Brazil as part of the national programme against zoonotic visceral leishmaniosis.

The control of common endoparasites of dogs (e.g., A. caninum and T. canis) and cats (e.g., A. braziliense and T. cati) usually consists of the routine administration of anthelminthics associated with vector control for those that are vector borne (e.g., D. caninum, D. immitis, and P. praeputialis); reviewed in Ref. [8]. Indeed, the control of zoonotic tapeworms (e.g., E. granulosus) may be effectively performed by the systematic use of praziquantel. For instance, a pilot control programme was conducted in southern Brazil, in which 44 rural dogs were treated monthly with praziquantel during 8 months [192]. At the beginning of the programme, 17 out 44 (28%) dogs were positive for E. granulosus coproantigens by ELISA and 30 days after the last treatment administration no dog was found positive [192]. Specifically, in the case of the double-pore tapeworm D. caninum, the control of fleas and lice is also advocated [8].

The level of awareness and compliance of pet owners may be low in some settings, particularly in outskirts and rural areas. Even if an important part of pet owners in Brazil cannot handle the costs of year-round preventive programmes, the lack of compliance of wealthy people to cope with veterinary recommendations is usually due to their reduced risk perception. Alternative strategies have been proposed, including the use of the nematophagous fungus Pochonia chlamydosporia as a biological control agent against embryonated eggs of T. canis [230]. Nevertheless, these alternatives are still a bit far from reality in Brazil.

Finally, the control of vector-borne parasites is usually based on the use of repellents on animals and on the control of arthropod vectors in the environment, whenever applicable [9, 231]; e.g., for the control of H. canis, which is associated with high levels of environmental tick infestation [232, 233]. However, other strategies such as dog culling have long been used in Brazil to control zoonotic visceral leishmaniasis, even if this strategy has been considered unethical and scientifically unsound [234]. Recently, the Minister Joaquim Barbosa, President of the Supreme Federal Court of Brazil, refused the request to suspend the judgment of the Interministerial Ordinance 1.426/2008, which prohibits the treatment and recommends the euthanasia of L. infantum-infected dogs ( The Minister stated that this Ordinance violates the Federal Constitution and that the public power should find alternatives to confront this issue, in partnership with scientists and veterinarians.

Prevention is better than cure

Most dog owners seek the aid of a veterinary practitioner only when their animals display overt disease signs. This is particularly true in developing countries, where most dog owners cannot handle the costs of year-round preventive programmes. Naturally, in some rural and suburban areas the level of compliance may be even more reduced. Nonetheless, a considerable number of pet owners are increasingly aware of the risks and potential costs attached to the non-adoption of preventive measures directed at avoiding the exposure to certain pathogens, such as L. infantum. Thus, it is fundamental that veterinary practitioners recommend preventatives to pet owners towards the establishment of a long-term preventive programme against endoparasites and ectoparasites in Brazil.

The only vaccines against parasitic diseases available in Brazil are those against leishmaniosis, which are designed and approved against “canine leishmaniosis”, not against “L. infantum infection”. Indeed, none of the currently available vaccines against canine leishmaniosis will prevent dogs from becoming infected by L. infantum, but they should reduce the probability of vaccinated dogs to develop overt disease [231]. Importantly, if a vaccinated dog is able to mount an effective immune response against L. infantum, it will probably maintain the parasitic burden at low levels, eventually representing a poor source of parasites to phlebotomine vectors [235]. But again, it is important to emphasize that vaccines are not repellents and thus will not prevent dogs from being bitten by phlebotomine sand flies [235].

The use of repellents on dogs is an important strategy against ectoparasites and the pathogens they transmit [236238]. Currently, there are several products formulated as spot-on solutions, collars, and sprays with fast killing effects, but synthetic pyrethroids remain the only chemical compounds with repellent properties available in the global veterinary market [239]. By virtue of their repellent and anti-feeding effects, synthetic pyrethroids (e.g., deltamethrin and permethrin) are highly efficacious against ectoparasites such as fleas, lice, sand flies, and ticks, but may also help to prevent the transmission of pathogens such as B. vogeli, E. canis, and L. infantum [236238]. In the same way, some products with a fast killing effect are able to interrupt the attachment and blood feeding processes at their very early stages, thus also reducing the risk of pathogen transmission [240, 241].

Dogs, cats, parasites and humans: public health aspects

While some dog and cat ectoparasites are strictly associated to these animals, some of them may also infest humans. For instance, cases of human infestation by dog-associated ticks (e.g., A. aureolatum, A. ovale, and R. sanguineus s.l.) have sporadically been described in different Brazilian regions [242247]. Cases of human infestations by dog ticks (R. sanguineus s.l.) appear to be associated with high levels of environmental infestation in human dwellings and with people working in veterinary clinics or kennels [242, 244]. Importantly, some of these ticks may potentially transmit life-threatening pathogens to humans, including Rickettsia rickettsii[248]. For instance, R. sanguineus s.l. ticks have been implicated in the transmission of rickettsial organisms (e.g., Rickettsia conorii, Rickettsia massiliae, and R. rickettsii) to humans in the Mexico, the United States and the Mediterranean region [3]. Moreover, cases of human ehrlichiosis by E. canis have been described in Venezuela [249] and there is serological evidence that humans may be in jeopardy of being infected by E. canis in Brazil as well [250]. Importantly, E. canis is widespread and highly prevalent in Brazil [199, 251255], being primarily vectored by R. sanguineus s.l. ticks [256]. Cases of human infestation by Ctenocephalides spp. fleas have also been reported in Brazil [13, 257], and it is now acknowledged that those fleas may carry Rickettsia felis [258], an emerging human pathogen worldwide [259]. It means that the control of some common dog and cat ectoparasites (e.g., C. felis felis and R. sanguineus s.l.) is fundamental not only for their health, but also to safeguard the health of their owners.

Ascarids (Toxocara spp.) and hookworms (Ancylostoma spp.) of dogs and cats are parasites of great veterinary and public health relevance, even if the general perception of pet owners is that intestinal parasites of dogs and cats are of minor public health significance; reviewed in Ref. [260]. For instance, a study carried out in south-eastern Brazil revealed that most dog owners do not know the species of dog intestinal parasites, the mechanisms of transmission, the risk factors for zoonotic infections, and specific prophylactic measures [100]. Nonetheless, a number of cases of visceral and cutaneous larva migrans in humans have been described in Brazil [261264] and serological data confirmed a high level of exposure to Toxocara spp. in humans in this country, reaching over 50% in some cities [265269]. Accordingly, high levels of environmental contamination by Toxocara and Ancylostoma eggs in public parks and squares have been reported in different Brazilian regions [270274]. Furthermore, human lagochilascariasis is an emerging zoonosis in the Americas caused by the roundworm Lagochilascaris minor and has been sporadically reported in Brazil [275279], which holds the largest number of human cases reported in the literature [280]. Cats have been found naturally infested by L. minor and Lagochilascaris major in Brazil [281283]. Indeed, the role of cats as reservoirs of L. minor has been speculated [284] and the contamination by Lagochilascaris eggs in public playgrounds has been documented in southern Brazil [285]. The soil contamination by dog and cat faeces is a common phenomenon in public gardens, sand boxes, and beaches (Figure 5) in Brazil, not only due to the large population of stray animals present in the cities, but also due to the lack of proper sanitary and health education of some pet owners.

Figure 5

Environmental contamination with dog faeces. Stray dogs roaming freely in a beach in southern Brazil. Dog faeces are an important source of zoonotic parasites that may cause diseases such as cutaneous larva migrans.

Tapeworms are also an underestimated problem in Brazil and other South American countries. For instance, human cases of D. caninum have been described in Brazil [286288]. Indeed, the high prevalence of D. caninum in dogs in Brazil (e.g., 45.7% in north-eastern and 36.8% in south-eastern Brazil) [32, 36] is a consequence of the high prevalence of flea and lice infestations reported in different regions of the country [18, 28, 30, 32, 35] and indicates a high risk of zoonotic transmission in humans, particularly children, who live in close contact with infected animals. In the same way, cystic echinococcosis caused by E. granulosus is one of the most prevalent zoonosis in Argentina, Brazil, Chile, Peru, and Uruguay [289], being highly prevalent in southern Brazil, where up to 50% of the dogs may be infested [72, 290]. While other canids (Pseudalopex gymnocercus, Cerdocyon thous, and Chrysocyon brachyurus) have been found naturally infested by E. granulosus in southern Brazil [290], dogs are the main reservoir of the parasite. In southern Brazil, E. granulosus is maintained principally in a dog-sheep cycle, with the sheep strain (G1) as the most prevalent genotype; reviewed in Ref. [290]. Furthermore, human cases of polycystic echinococcosis by Echinococcus vogeli have been diagnosed in northern Brazil [291] and dogs have also been suspected to play a role in the zoonotic transmission of this parasite in the Neotropical region [292]. Similarly, experimental evidence indicates that cats may act as definitive hosts for E. oligarthrus [293], another agent of polycystic echinococcosis in humans in Latin America [292], which is traditionally associated with wild felids. Last but not least, there is limited published information on other dog-associated taenids (e.g., T. hydatigena and T. multiceps) in Brazil [91], which suggests that human cysticercosis and coenuruses may be a silent, underestimated public health problem in some regions of this country.

Human pulmonary dirofilariosis is another common, yet underestimated public health issue in Brazil; reviewed in Ref. [294]. Even if several human cases have been described in the literature, most cases are accidentally found by chance on chest radiographies and chest computerized tomography scans, which are usually requested for other reasons [295]. Furthermore, even if most patients with pulmonary dirofilariosis present no apparent clinical signs, many of them will present cough, chest pain, haemoptysis, and dyspnoea [295298]. Most importantly, the presence of pulmonary nodules could lead to the suspicion of diseases such as tuberculosis or lung cancer and in these cases thoracotomy is usually recommended. Indeed, human pulmonary dirofilariosis is a public health issue that has been so far neglected in Brazil. In the same way, the recent report of a case of ocular dirofilariosis in northern Brazil [299] suggests the risk of Dirofilaria infestation in certain Brazilian regions may be higher than currently appreciated.

Zoonotic protozoa are also a serious public health issue in Brazil. For instance, thousands of human cases of visceral leishmaniosis caused by L. infantum are notified each year to the Ministry of Health, but control measures mostly based on the elimination of seropositive dogs, vector control (in specific situations) and human treatment have not been enough to control the disease [300]. Indeed, human visceral leishmaniosis is widespread in all Brazilian regions, being less common in the southern part of the country [301]. The occurrence of asymptomatic Leishmania infections in humans has been documented in different regions of the country [302304] and even if the Ministry of Health of Brazil affords the treatment of human patients, the lethality rate may reach 18.4% or much higher in some settings [305307]. Another important zoonotic protozoan is T. gondii, an opportunistic pathogen highly prevalent in Brazil. Indeed, studies indicate that up to 50% of elementary school children and 50-80% of women of child-bearing age have anti-T. gondii antibodies; reviewed in Ref. [308]. A recent outbreak of acute toxoplasmosis in an industrial plant in São Paulo, south-eastern Brazil, indicated that ingestion of green vegetables (not meat or water) was associated with the incidence of acute disease [309]. Another recent study revealed a high seropositivity (80%) among HIV-positive patients from southern Brazil, some of which had a history of neurotoxoplasmosis (4.8%) and ocular toxoplasmosis (1.6%) [310].

Chagas disease caused by T. cruzi remains an important public health issue in the Americas, affecting about 10% of the poorest people in the region [311]. Dogs and cats are considered important reservoirs of T. cruzi in the domestic cycle of transmission [312]. For instance, studies indicate that around 15-50% of dogs living in areas where Chagas disease is endemic are seropositive [313318]. However, the real role played by dogs and cats in the transmission cycle of T. cruzi in the current epidemiological context of Chagas disease in Brazil is arguable, because the great majority of recent human cases have been associated with oral transmission, via the ingestion of contaminated juices [319].

Final considerations and future research directions

Brazil holds a vast territory and one of the largest dog and cat populations on the Planet. The economic growth and the increasing level of human development recorded in Brazil are provoking profound changes in the attitude of some dog owners and veterinary practitioners towards high-standard healthcare services. Nonetheless, the macroeconomic boom masks historical inequalities in terms of access to basic sanitation, decent housing, safe drinking water, health care and education at both local and regional levels. So, in reality, many dog owners cannot afford preventive measures and will act only when a life-threatening problem is affecting their animals. Furthermore, Brazil is still home to a large population of dogs and cats living as “strays” or “community” animals, not only in rural areas, but also in suburbs and large urban centres. Public health authorities are not able to manage these animals due to the lack of adequate infrastructure and trained personnel to conduct an effective long-term population control program. As a result, pet dogs and cats are usually endangered by a wide range of parasites that may cause disease in them and eventually in their human counterpart. This invariably brings us to the One Health concept, which invites veterinary practitioners and medical physicians to unify their efforts to combat zoonotic parasites (e.g., T. canis, A. caninum, D. caninum, D. immitis, E. granulosus, and L. infantum). Indeed, the unification of “veterinary and human medicines” in One Medicine is fundamental, instrumentally to reduce health hazards to pet animals and humans.

The outstanding diversity of ectoparasites infesting dogs and cats in Brazil is certainly a consequence of a combination of factors. The variety of natural environments and climates occurring in this country is impressive and favours the establishment of different parasites in all geographical regions. In the same way, dogs and cats living in either urban or rural areas may eventually live in close contact with livestock and wildlife species (e.g., foxes, wild cats, and opossums), which ultimately may favour the exchange of ectoparasites such as fleas and ticks with these animals [320323]. For instance, R. sanguineus s.l. has been found on coati (Nasua nasua) living in a zoological park in a large urban area in north-eastern Brazil [322]. Even if this is an accidental finding, it suggests the presence of stray dogs circulating freely within the park’s territory and living in close contact with captive wild animals. Conversely, dogs and cats intruding or living near to forested environments may be found infested by wildlife-associated ectoparasites [12, 28, 50, 321]. The exchange of ectoparasites between domestic and wild animals may also have implications from a conservational perspective, also because dogs may exchange endoparasites [324326] and viruses [327, 328] with wildlife species. For example, several wild canids (e.g., C. thous and P. gymnocercus) and felids (e.g., Panthera onca, Puma concolor, Puma yagouaroundi, and Leopardus pardalis) have been found harbouring parasites that may affect dogs and cats, including heminths (e.g., A. caninum, D. caninum, T. canis, and T. vulpis) and protozoa (e.g., L. infantum) [324326, 329333]. Remarkably, while free-roaming wild canids infected with L. infantum are usually asymptomatic, captive ones seems to be more prone to develop clinical signs [329] and may even die from infection [332].

Veterinary practitioners working in Brazil are provided with a vast repertory of products with proven efficacy against dog and cat parasites. Indeed, the registration of veterinary products in Brazil involves several phases and strict regulatory requirements [334]. However, the success of any parasite control programme depends on the correct use of the chosen product(s) and on the adoption of the best strategy for each situation. As previously discussed, guidelines for the diagnosis, treatment and control of dog and cat parasites in Brazil are currently lacking and are urgently needed. In the meantime, veterinary practitioners working in Brazil should adhere strictly to manufacturers’ instructions while using commercially available products and follow international guidelines for the control of dog and cat parasites, eventually adapting them to regional situations. In addition, the Brazilian Ministry of Agriculture, Livestock and Food Supply recently established the use of a passport for international transit of dogs and cats (,caes-e-gatos-terao-passaporte-e-identificacao-eletronica,1099476,0.htm). This passport will be used as a health certification of origin and will include information about ecto- and endoparasite control. This will help to reduce the risk of unintentional exportation of parasites from Brazil to overseas.

There are many outstanding questions regarding parasites of dogs and cats in Brazil, some of which may have already been answered at the time that this manuscript is being drafted. For instance, it is important to understand why some parasites are apparently restricted to the southern and south-eastern regions of Brazil [9]. This is the case of R. vitalii and B. gibsoni, for example. While B. gibsoni is a relatively rare parasite in dogs in Brazil, R. vitalii is quite common in southern and south-eastern states and may cause severe disease that can be easily misdiagnosed with babesiosis or ehrlichiosis. Interestingly, the vectors of both protozoa remain unknown, but Amblyomma aureolatum is the putative vector for R. vitalii, at least. With this regard, the role of R. sanguineus s.l. in the natural cycle of H. canis in Brazil needs further investigation. Accordingly, other tick species have been implicated as putative vectors of this orally transmitted protozoan, including A. ovale [335, 336] and Rhipicephalus microplus [337]. Some parasites of dogs and cats have only rarely been reported in Brazil, probably due to the limited research effort on these little studied parasites, whose veterinary and medical significance has yet to be ascertained. For instance, enigmatic parasites such as Cercopithifilaria bainae [338] have been originally described in Brazil, but remained doubtful and neglected for long time. Recently, this nematode was redescribed and it is emerging as a common filarioid of dogs in different European countries [339, 340]. Altogether, these examples evidence that much has still to be discovered in Brazil regarding parasites of dogs and cats.

Further research on dog and cat parasites in Brazil may also reveal the existence of new species that have been overlooked over the years. Indeed, the use of molecular biology is revolutionizing in a positive fashion our knowledge on some “well-known” parasites, such as the brown dog tick R. sanguineus s.l. [52, 161, 162, 341]. Likewise, genetic data suggested that nematodes identified as A. vasorum in dogs from South America may represent a different species from that observed in European dogs [342]. In this perspective, the use of molecular biology techniques should become a reality in the daily routine of veterinary practitioners working in Brazil and therefore the development of rapid, economically accessible molecular tools should be a research priority. For example, serological tests currently used by public authorities are not able to discriminate dogs infected by L. infantum from those infected by L. braziliensis or even distinguish vaccinated from naturally infected dogs [343]. Therefore, veterinary practitioners should request additional tests (e.g., parasite isolation and characterization, PCR and DNA sequencing) to confirm whether the dog is actually infected by L. infantum in order to avoid the elimination of dogs infected by other parasites and to decide about the most appropriate therapeutic approach to be adopted. With this respect, it is also important to monitor the emergence of resistance to certain active principles (e.g., amitraz, fipronil, deltamethrin, and permethrin), as these compounds have long been used for ectoparasite control in Brazil. Likewise, there is no information regarding the efficacy level of some endoparasiticides (e.g., praziquantel, pyrantel, febantel, and ivermectin), which are widely used in different Brazilian regions. These issues should be included in the research agenda of parasitologists in Brazil in order to anticipate problems related to parasite resistance to active principles currently used for controlling ectoparasites and endoparasites of dogs and cats in this country.


In conclusion, the benefits of having a dog or a cat as a pet are undisputed, but the limit between benefit and prejudice is subtle. Indeed, the close contact between pets and humans may involuntarily represent a hazard for humans. Therefore, to avoid the potential risks associated to owning a pet dog or cat, it is fundamental to maintain them in good health and protected from zoonotic pathogens. Beyond the shadow of a doubt, it is our job as veterinarians to ensure that pets and their owners may live in harmony without representing a menace to each other. But from a holistic perspective, veterinary practitioners and medical physicians should work together towards improving the wellbeing and general health of both animals and humans. Paraphrasing a famous American singer, a One Health approach could help us to “heal the world” and “make it a better place” for dogs, cats, and humans.


  1. 1.

    McConnell AR, Brown CM, Shoda TM, Stayton LE, Martin CE: Friends with benefits: on the positive consequences of pet ownership. J Pers Soc Psychol. 2011, 101: 1239-1252.

  2. 2.

    Irwin PJ: Companion animal parasitology: a clinical perspective. Int J Parasitol. 2002, 32: 581-593. 10.1016/S0020-7519(01)00361-7.

  3. 3.

    Dantas-Torres F, Chomel BB, Otranto D: Ticks and tick-borne diseases: a One Health perspective. Trends Parasitol. 2012, 28: 437-446. 10.1016/

  4. 4.

    Lorusso V, Dantas-Torres F, Caprio F, Manzionna M, Santoro N, Baneth G, Otranto D: Paediatric visceral leishmaniasis in Italy: a 'One Health' approach is needed. Parasit Vectors. 2013, 6: 123-10.1186/1756-3305-6-123.

  5. 5.

    Pullan R, Brooker S: The health impact of polyparasitism in humans: are we under-estimating the burden of parasitic diseases?. Parasitology. 2008, 135: 783-794.

  6. 6.

    den Boer M, Argaw D, Jannin J, Alvar J: Leishmaniasis impact and treatment access. Clin Microbiol Infect. 2011, 17: 1471-1477. 10.1111/j.1469-0691.2011.03635.x.

  7. 7.

    Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, McCarthy JS, Basáñez MG: A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis. 2012, 6: e1582-10.1371/journal.pntd.0001582.

  8. 8.

    Ribeiro VM: Controle de helmintos de cães e gatos. Rev Bras Parasitol Vet. 2004, 13 (Suppl 1): 88-95.

  9. 9.

    Dantas-Torres F: Canine vector-borne diseases in Brazil. Parasit Vectors. 2008, 1: 25-10.1186/1756-3305-1-25.

  10. 10.

    Reck J, Soares JF, Termignoni C, Labruna MB, Martins JR: Tick toxicosis in a dog bitten by Ornithodoros brasiliensis. Vet Clin Pathol. 2011, 40: 356-360. 10.1111/j.1939-165X.2011.00338.x.

  11. 11.

    Evans DE, Martins JR, Guglielmone AA: A review of the ticks (Acari, ixodida) of Brazil, their hosts and geographic distribution - 1. The state of Rio Grande do Sul, southern Brazil. Mem Inst Oswaldo Cruz. 2000, 95: 453-470. 10.1590/S0074-02762000000400003.

  12. 12.

    Labruna MB, Homem VS, Heinemann MB, Ferreira Neto JS: Ticks (Acari: Ixodidae) associated with rural dogs in Uruará, eastern Amazon, Brazil. J Med Entomol. 2000, 37: 774-776. 10.1603/0022-2585-37.5.774.

  13. 13.

    Linardi PM, Guimarães LR: Sifonápteros do Brasil. 2000, São Paulo: Museu de Zoologia USP/FAPESP

  14. 14.

    Guimarães JH, Tucci EC, Barros-Battesti DM: Ectoparasitos de importância veterinária. 2001, São Paulo: Plêiade/FAPESP

  15. 15.

    Rodrigues AFSF, Daemon E, D'Agosto M: Investigação sobre alguns ectoparasitos em cães de rua no município de Juiz de Fora, Minas Gerais. Rev Bras Parasitol Vet. 2001, 10: 13-19.

  16. 16.

    Szabó MP, Cunha TM, Pinter A, Vicentini F: Ticks (Acari: Ixodidae) associated with domestic dogs in Franca region, São Paulo, Brazil. Exp Appl Acarol. 2001, 25: 909-916. 10.1023/A:1020433003028.

  17. 17.

    Bellato V, Sartor AA, Souza AP, Ramos BC: Ectoparasites in dogs from Lages municipality, Santa Catarina, Brazil. Rev Bras Parasitol Vet. 2003, 12: 95-98.

  18. 18.

    Dantas-Torres F, Figueredo LA, Faustino MAG: Ectoparasites of dogs from some municipalities of the metropolitan region of Recife, Pernambuco state, Brazil. Rev Bras Parasitol Vet. 2004, 13: 151-154.

  19. 19.

    Heukelbach J, Costa AM, Wilcke T, Mencke N, Feldmeier H: The animal reservoir of Tunga penetrans in severely affected communities of north-east Brazil. Med Vet Entomol. 2004, 18: 329-335. 10.1111/j.0269-283X.2004.00532.x.

  20. 20.

    Souza CP, Scott FB, Pereira MJS: Validity and reprodutibility of otoscopy and pinnal pedal reflex on the diagnostic of Otodectes cynotis infestation in dogs. Rev Bras Parasitol Vet. 2004, 13: 111-114.

  21. 21.

    Scofield A, Riera MDF, Elisei C, Massard CL, Linardi PM: Occurrence of Rhopalopsyllus lutzi lutzi (Baker) (Siphonaptera, Rhopalopsyllidae) on Canis familiaris (Linnaeus) from rural areas of the county of Piraí, State of Rio de Janeiro, Brazil. Rev Bras Entomol. 2005, 49: 159-161. 10.1590/S0085-56262005000100019.

  22. 22.

    Castro MCM, Rafael JA: Ectoparasites on cats and dogs from Manaus, Amazonas State, Brazil. Acta Amaz. 2006, 36: 535-538. 10.1590/S0044-59672006000400015.

  23. 23.

    Soares AO, Souza AD, Feliciano EA, Rodrigues AF, D'Agosto M, Daemon E: Evaluation of ectoparasites and hemoparasites in dogs kept in apartments and houses with yards in the city of Juiz de Fora, Minas Gerais, Brazil. Rev Bras Parasitol Vet. 2006, 15: 13-16.

  24. 24.

    Dantas-Torres F, Figueredo LA: Heterodoxus spiniger (Enderlein, 1909) on domestic dogs (Canis familiaris, L. 1758) from the city of Recife, Pernambuco state, Brazil. Braz J Vet Res Anim Sci. 2007, 43: 77-80.

  25. 25.

    Szabó MP, Olegário MM, Santos AL: Tick fauna from two locations in the Brazilian savannah. Exp Appl Acarol. 2007, 43: 73-84. 10.1007/s10493-007-9096-8.

  26. 26.

    Cardoso CP, Stalliviere FM, Schelbauer CA, de Souza AP, Bellato V, Sartor AA: Amblyomma tigrinum in the municipality of Lages, SC, and biology observations under laboratory conditions. Rev Bras Parasitol Vet. 2008, 17: 56-58. 10.1590/S1984-29612008000100013.

  27. 27.

    Rocha GS, Ahid SMM, Bezerra ACDS, Filgueira KD, Santos JPS: Mites frequency in dogs and cats at the city of Mossoro, Rio Grande do Norte, Brazil. Acta Sci Vet. 2008, 36: 263-266.

  28. 28.

    Rodrigues DF, Daemon E, Rodrigues AF: Characterization of ectoparasites on dogs in the nucleus of urban expansion of Juiz de Fora, Minas Gerais, Brazil. Rev Bras Parasitol Vet. 2008, 17: 185-188.

  29. 29.

    Dantas-Torres F: Ticks on domestic animals in Pernambuco, Northeastern Brazil. Rev Bras Parasitol Vet. 2009, 18: 22-28. 10.4322/rbpv.01803004.

  30. 30.

    Dantas-Torres F, Melo MF, Figueredo LA, Brandão-Filho SP: Ectoparasite infestation on rural dogs in the municipality of São Vicente Férrer, Pernambuco, Northeastern Brazil. Rev Bras Parasitol Vet. 2009, 18: 75-77. 10.4322/rbpv.01803014.

  31. 31.

    Martins TF, Spolidorio MG, Batista TC, Oliveira IA, Yoshinari NH, Labruna MB: Occurrence of ticks (Acari: Ixodidae) in the municipality of Goiatins, Tocantins. Rev Bras Parasitol Vet. 2009, 18: 50-52. 10.4322/rbpv.01802011.

  32. 32.

    Klimpel S, Heukelbach J, Pothmann D, Rückert S: Gastrointestinal and ectoparasites from urban stray dogs in Fortaleza (Brazil): high infection risk for humans?. Parasitol Res. 2010, 107: 713-719. 10.1007/s00436-010-1926-7.

  33. 33.

    Szabó MP, de Souza LG, Olegário MM, Ferreira FA FA, de Albuquerque Pajuaba Neto A: Ticks (Acari: Ixodidae) on dogs from Uberlândia, Minas Gerais, Brazil. Transbound Emerg Dis. 2010, 57: 72-74. 10.1111/j.1865-1682.2010.01111.x.

  34. 34.

    Guimarães AM, Lima BS, Rocha CMBM: Parasitic ectofauna of urban domiciled dogs examined in private veterinary clinics from Lavras municipality, Minas Gerais state, Brazil. Cien Anim Bras. 2011, 12: 172-177.

  35. 35.

    Costa-Junior LM, Rembeck K, Mendonça FL, Azevedo SC, Passos LM, Ribeiro MF: Occurrence of ectoparasites on dogs in rural regions of the state of Minas Gerais, Brazil. Rev Bras Parasitol Vet. 2012, 21: 237-242. 10.1590/S1984-29612012000300011.

  36. 36.

    Heukelbach J, Frank R, de Ariza L, de Sousa Lopes I, de Assis E, Silva A, Borges AC, Limongi JE, de Alencar CH, Klimpel S: High prevalence of intestinal infections and ectoparasites in dogs, Minas Gerais State (southeast Brazil). Parasitol Res. 2012, 111: 1913-1921. 10.1007/s00436-012-3037-0.

  37. 37.

    Mazioli R, Szabó M, Mafra C: Amblyomma nodosum (Acari: Ixodidae) parasitizing a domestic dog in Colatina, Espírito Santo, Brazil. Rev Bras Parasitol Vet. 2012, 21: 428-432. 10.1590/S1984-29612012005000006.

  38. 38.

    Santos JL, Magalhães NB, Dos Santos HA, Ribeiro RR, Guimarães MP: Parasites of domestic and wild canids in the region of Serra do Cipó National Park, Brazil. Rev Bras Parasitol Vet. 2012, 21: 270-277. 10.1590/S1984-29612012000300016.

  39. 39.

    Costa AP, Silva AB, Costa FB, Xavier GS, Martins TF, Labruna MB, Guerra RM: A survey of ectoparasites infesting urban and rural dogs of Maranhão state, Brazil. J Med Entomol. 2013, 50: 674-678. 10.1603/ME12243.

  40. 40.

    Reck J, Marks FS, Guimarães JA, Termignoni C, Martins JR: Epidemiology of Ornithodoros brasiliensis (mouro tick) in the southern Brazilian highlands and the description of human and animal retrospective cases of tick parasitism. Ticks Tick Borne Dis. 2013, 4: 101-109. 10.1016/j.ttbdis.2012.09.004.

  41. 41.

    Souza CP, Verocai GG, Balbi M, Scott FB: Video otoscopy as a diagnostic tool for canine otoacariasis. Rev Bras Parasitol Vet. 2013, 22: 440-442.

  42. 42.

    Mendes-de-Almeida F, Faria MC, Branco AS, Serrão ML, Souza AM, Almosny N, Charme M, Labarthe N: Sanitary conditions of a colony of urban feral cats (Felis catus Linnaeus, 1758) in a zoological garden of Rio de Janeiro, Brazil. Rev Inst Med Trop Sao Paulo. 2004, 46: 269-274.

  43. 43.

    Pereira SA, Schubach TMP, Figueiredo FB, Paes Leme LR, Santos IB, Okamoto T, Cuzzi T, Reis RS, Schubach A: Demodicosis associated with sporotrichosis and pediculosis in a positive FIV/FeLV cat. Acta Sci Vet. 2005, 33: 75-78.

  44. 44.

    Mendes-de-Almeida F, Labarthe N, Guerrero J, Faria MC, Branco AS, Pereira CD, Barreira JD, Pereira MJ: Follow-up of the health conditions of an urban colony of free-roaming cats (Felis catus Linnaeus, 1758) in the city of Rio de Janeiro, Brazil. Vet Parasitol. 2007, 147: 9-15. 10.1016/j.vetpar.2007.03.035.

  45. 45.

    Romeiro ET, Alves LC, Soares YM, Matoso UN, Faustino MA: Infestation by Lynxacarus radovskyi (Tenorio, 1974) in domestic cats from Metropolitan Region of Recife, Pernambuco, Brazil. Rev Bras Parasitol Vet. 2007, 16: 159-162. 10.1590/S1984-29612007000300009.

  46. 46.

    Aguiar J, Machado MLS, Ferreira RR, Hünning PS, Muschner AC, Ramos RZ: Mixed infestation by Lynxacarus radovskyi and Felicola subrostratus in a cat in Porto Alegre, RS, Brazil. Acta Scie Vet. 2009, 37: 301-305.

  47. 47.

    Stalliviere FM, Bellato V, Souza AP, Sartor AA, Moura AB, Rosa LD: Ectoparasites and intestinal helminths in Felis catus domesticus from Lages city, SC, Brazil and social-economical and cultural aspects of owners of family pets. Rev Bras Parasitol Vet. 2009, 18: 26-31. 10.4322/rbpv.01804005.

  48. 48.

    Ferreira DRA, Alves LC, Faustino MAG: Ectoparasitic species from Felis catus domesticus (Linnaeus, 1758) in João Pessoa city, Paraíba state, Brazil. Biotemas. 2010, 23: 43-50.

  49. 49.

    Mendes-de-Almeida F, Crissiuma AL, Gershony LC, Willi LM, Paiva JP, Guerrero J, Labarthe N: Characterization of ectoparasites in an urban cat (Felis catus Linnaeus, 1758) population of Rio de Janeiro, Brazil. Parasitol Res. 2011, 108: 1431-1435. 10.1007/s00436-010-2189-z.

  50. 50.

    Silva AS, Silva MK, Monteiro SG: Parasitism by Amblyomma triste in domestic cat. Rev Bras Parasitol Vet. 2007, 16: 108-109.

  51. 51.

    Linardi PM, Santos JL: Ctenocephalides felis felis vs. Ctenocephalides canis (Siphonaptera: Pulicidae): some issues in correctly identify these species. Rev Bras Parasitol Vet. 2012, 21: 345-354. 10.1590/S1984-29612012000400002.

  52. 52.

    Dantas-Torres F, Latrofa MS, Annoscia G, Giannelli A, Parisi A, Otranto D: Morphological and genetic diversity of Rhipicephalus sanguineus sensu lato from the New and Old Worlds. Parasit Vectors. 2013, 6: 213-10.1186/1756-3305-6-213.

  53. 53.

    Barros-Battesti DM, Arzua M, Bechara GH: Carrapatos de importância médico-veterinária da Região Neotropical: Um guia ilustrado para identificação de espécies. São Paulo. 2006, Butantan: Vox/International Consortium on Ticks and Tick-borne Diseases (ICTTD-3)

  54. 54.

    Aragão HB, Fonseca F: Notas de ixodologia. VIII. Lista e chave para os representantes da fauna ixodológica brasileira. Mem Inst Oswaldo Cruz. 1961, 59: 115-129.

  55. 55.

    Labruna MB, Campos Pereira M: Carrapato em cães no Brasil. Clin Vet. 2001, 30: 24-32.

  56. 56.

    Martins TF, Onofrio VC, Barros-Battesti DM, Labruna MB: Nymphs of the genus Amblyomma (Acari: Ixodidae) of Brazil: descriptions, redescriptions, and identification key. Ticks Tick Borne Dis. 2010, 1: 75-99. 10.1016/j.ttbdis.2010.03.002.

  57. 57.

    Azeredo-Espin AM, Madeira NG: Primary myiasis in dog caused by Phaenicia eximia (Diptera: Calliphoridae) and preliminary mitochondrial DNA analysis of the species in Brazil. J Med Entomol. 1996, 33: 839-843.

  58. 58.

    Silva Junior VP, Souza Leandro A, Moya Borja GE: Occurrence of berne, Dermatobia hominis (Diptera: Cuterebridae) in several host, in the Rio de Janeiro. Brazil. Parasitol día. 1998, 22: 97-101.

  59. 59.

    Cramer-Ribeiro BC, Sanavria A, Oliveira MQ, Souza FS, Rocco FS, Cardoso PG: Inquiry of cases of myiasis by Cochliomyia hominivorax in dogs of the southern zone of Rio de Janeiro city in 2000. Braz J Vet Res Anim Sci. 2002, 39: 171-175.

  60. 60.

    Cramer-Ribeiro BC, Sanavria A, Oliveira MQ, Souza FS, Rocco FS, Cardoso PG: Inquiry of cases of myiasis by Dermatobia hominis in dogs of the southern zone of Rio de Janeiro municipality in 2000. Braz J Vet Res Anim Sci. 2002, 39: 176-180.

  61. 61.

    Cramer-Ribeiro BC, Sanavria A, Monteiro HHMS, Oliveira MQ, Souza FS: Inquiry of cases of myiasis by Cochliomyia hominivorax in dogs (Canis familiaris) of the Northern and Western zones of Rio de Janeiro city in 2000. Braz J Vet Res Anim Sci. 2003, 40: 13-20. 10.1590/S1413-95962003000100001.

  62. 62.

    Cardozo SV, Ramadinha RR: Evaluation of myiasis treatment in dogs using nitenpyram. R Bras Ci Vet. 2007, 14: 139-142.

  63. 63.

    Correia TR, Scott FB, Verocai GG, Souza CP, Fernandes JI, Melo RM, Vieira VP, Ribeiro FA: Larvicidal efficacy of nitenpyram on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs. Vet Parasitol. 2010, 173: 169-172. 10.1016/j.vetpar.2010.06.019.

  64. 64.

    Marotta CR, Scherer PO, Sanavria A: Cutaneous and oro-nasal internal myiasis by Cochliomyia hominivorax (Coquerel, 1858) in feline (Felis catus) - Case report. Rev Bras Med Vet. 2011, 33: 137-141.

  65. 65.

    Cansi ER, Demo C: Occurrence of myiasis in pets from the Federal District, in Brazil. Acta Sci Vet. 2011, 39: 982-

  66. 66.

    Barros ATM, Koller WW, Catto JB, Soares CO: Stomoxys calcitrans outbreaks in pastured beef cattle in the State of Mato Grosso do Sul, Brazil. Pesq Vet Bras. 2010, 30: 945-952.

  67. 67.

    Freitas MG, Costa HMA: Lista de helmintos parasitos dos animais domésticos do Brasil. Arq Esc Vet UFMG. 1959, 12: 443-510.

  68. 68.

    Travassos L, Freitas JFT, Kohn A: Trematódeos do Brasil. Mem Inst Oswaldo Cruz. 1959, 67: 1-886.

  69. 69.

    Vicente JJ, Rodrigues HO, Gomes DC, Pinto RM: Nematóides do Brasil. Parte V. Nematóides de mamíferos. Rev Bras Zool. 1997, 14 (Supl 1): 1-452.

  70. 70.

    Costa JO, Guimarães MP, Lima WS, Lima EA: Endo and ectoparasites of dogs from Vitoria county - Espírito Santo – Brazil. Arq Bras Med Vet Zootec. 1990, 42: 451-452.

  71. 71.

    Gennari SM, Kasai N, Pena HFJ, Cortez A: Occurrence of protozoa and helminthes in faecal samples of dogs and cats from São Paulo city. Braz J Vet Res An Sci. 1999, 36: 87-91.

  72. 72.

    Hoffmann AN, Malgor R, de la Rue ML: Prevalence of Echinococcus granulosus (Batsch, 1786) in urban stray dogs from Dom Pedrito in the state of Rio Grande do Sul, Brazil. Cienc Rural. 2001, 31: 843-847.

  73. 73.

    Gontijo CM, da Silva ES, de Fuccio MB, de Sousa MC, Pacheco RS, Dias ES, Andrade Filho JD, Brazil RP, Melo MN: Epidemiological studies of an outbreak of cutaneous leishmaniasis in the Rio Jequitinhonha Valley, Minas Gerais, Brazil. Acta Trop. 2002, 81: 143-150. 10.1016/S0001-706X(01)00205-4.

  74. 74.

    Oliveira-Sequeira TC, Amarante AF, Ferrari TB, Nunes LC: Prevalence of intestinal parasites in dogs from São Paulo State, Brazil. Vet Parasitol. 2002, 103: 19-27. 10.1016/S0304-4017(01)00575-1.

  75. 75.

    Oliveira-Júnior SD, Barçante JM, Barçante TA, Ribeiro VM, Lima WS: Ectopic location of adult worms and first-stage larvae of Angiostrongylus vasorum in an infected dog. Vet Parasitol. 2004, 121: 293-296. 10.1016/j.vetpar.2004.02.018.

  76. 76.

    Sreekumar C, Hill DE, Miska KB, Rosenthal BM, Vianna MC, Venturini L, Basso W, Gennari SM, Lindsay DS, Dubey JP: Hammondia heydorni: evidence of genetic diversity among isolates from dogs. Exp Parasitol. 2004, 107: 65-71. 10.1016/j.exppara.2004.04.009.

  77. 77.

    Blazius RD, Emerick S, Prophiro JS, Romão PR, Silva OS: Occurrence of protozoa and helminthes in faecal samples of stray dogs from Itapema City, Santa Catarina. Rev Soc Bras Med Trop. 2005, 38: 73-74.

  78. 78.

    Herrera HM, Norek A, Freitas TP, Rademaker V, Fernandes O, Jansen AM: Domestic and wild mammals infection by Trypanosoma evansi in a pristine area of the Brazilian Pantanal region. Parasitol Res. 2005, 96: 121-126. 10.1007/s00436-005-1334-6.

  79. 79.

    Passos LM, Geiger SM, Ribeiro MF, Pfister K, Zahler-Rinder M: First molecular detection of Babesia vogeli in dogs from Brazil. Vet Parasitol. 2005, 127: 81-85. 10.1016/j.vetpar.2004.07.028.

  80. 80.

    Rubini AS, dos Santos PK, Cavalcante GG, Ribolla PE, O'Dwyer LH: Molecular identification and characterization of canine Hepatozoon species from Brazil. Parasitol Res. 2005, 97: 91-93. 10.1007/s00436-005-1383-x.

  81. 81.

    Savani ES, Nunes VL, Galati EA, Castilho TM, Araujo FS, Ilha IM, Camargo MC, D'Auria SR, Floeter-Winter LM: Occurrence of co-infection by Leishmania (Leishmania) chagasi and Trypanosoma (Trypanozoon) evansi in a dog in the state of Mato Grosso do Sul, Brazil. Mem Inst Oswaldo Cruz. 2005, 100: 739-741. 10.1590/S0074-02762005000700011.

  82. 82.

    Andrade HM, Reis AB, dos Santos SL, Volpini AC, Marques MJ, Romanha AJ: Use of PCR-RFLP to identify Leishmania species in naturally-infected dogs. Vet Parasitol. 2006, 140: 231-238. 10.1016/j.vetpar.2006.03.031.

  83. 83.

    Silva LM, Miranda RR, Santos HA, Rabelo EM: Differential diagnosis of dog hookworms based on PCR-RFLP from the ITS region of their rDNA. Vet Parasitol. 2006, 40: 373-377.

  84. 84.

    Labruna MB, Pena HFJ, Souza SLP, Pinter A, Silva JCR, Ragozo AMA, Camargo LMA, Gennari SM: Prevalence of endoparasites in dogs from the urban area of Monte Negro municipality, Rondônia, Brazil. Arq Inst Biol São Paulo. 2006, 73: 183-193.

  85. 85.

    Madeira MF, Schubach A, Schubach TM, Pacheco RS, Oliveira FS, Pereira SA, Figueiredo FB, Baptista C, Marzochi MC: Mixed infection with Leishmania (Viannia) braziliensis and Leishmania (Leishmania) chagasi in a naturally infected dog from Rio de Janeiro, Brazil. Trans R Soc Trop Med Hyg. 2006, 100: 442-445. 10.1016/j.trstmh.2005.07.011.

  86. 86.

    Pereira BJ, Girardelli GL, Trivilin LO, Lima VR, Nunes Lde C, Martins IV: The occurrence of dioctophymosis in dogs from Municipality of Cachoeiro do Itapemirim in the State of Espírito Santo, Brazil, from May to December of 2004. Rev Bras Parasitol Vet. 2006, 15: 123-125.

  87. 87.

    Trapp SM, Messick JB, Vidotto O, Jojima FS, de Morais HS: Babesia gibsoni genotype Asia in dogs from Brazil. Vet Parasitol. 2006, 141: 177-180. 10.1016/j.vetpar.2006.04.036.

  88. 88.

    Velasquez LG, Membrive N, Membrive U, Rodrigues G, Reis N, Lonardoni MV, Teodoro U, Tessmann IP, Silveira TG: PCR in the investigation of canine American tegumentary leishmaniasis in northwestern Paraná State, Brazil. Cad Saude Publica. 2006, 22: 571-578. 10.1590/S0102-311X2006000300012.

  89. 89.

    Forlano MD, Teixeira KR, Scofield A, Elisei C, Yotoko KS, Fernandes KR, Linhares GF, Ewing SA, Massard CL: Molecular characterization of Hepatozoon sp. from Brazilian dogs and its phylogenetic relationship with other Hepatozoon spp. Vet Parasitol. 2007, 145: 21-30. 10.1016/j.vetpar.2006.10.023.

  90. 90.

    Gomes AH, Ferreira IM, Lima ML, Cunha EA, Garcia AS, Araújo MF, Pereira-Chioccola VL: PCR identification of Leishmania in diagnosis and control of canine leishmaniasis. Vet Parasitol. 2007, 144: 234-241. 10.1016/j.vetpar.2006.10.008.

  91. 91.

    Katagiri S, Oliveira-Sequeira TCG: Zoonoses caused by dog intestinal parasites and the problem of diagnosis. Arq Inst Biol. 2007, 74: 175-184.

  92. 92.

    Mundim MJ, Rosa LA, Hortêncio SM, Faria ES, Rodrigues RM, Cury MC: Prevalence of Giardia duodenalis and Cryptosporidium spp. in dogs from different living conditions in Uberlândia, Brazil. Vet Parasitol. 2007, 144: 356-359. 10.1016/j.vetpar.2006.09.039.

  93. 93.

    Nakagawa TL, Bracarense AP, dos Reis AC, Yamamura MH, Headley SA: Giant kidney worm (Dioctophyma renale) infections in dogs from Northern Paraná, Brazil. Vet Parasitol. 2007, 145: 366-370. 10.1016/j.vetpar.2006.10.027.

  94. 94.

    Souza SL, Gennari SM, Richtzenhain LJ, Pena HF, Funada MR, Cortez A, Gregori F, Soares RM: Molecular identification of Giardia duodenalis isolates from humans, dogs, cats and cattle from the state of São Paulo, Brazil, by sequence analysis of fragments of glutamate dehydrogenase (gdh) coding gene. Vet Parasitol. 2007, 149: 258-264. 10.1016/j.vetpar.2007.08.019.

  95. 95.

    Thomaz A, Meireles MV, Soares RM, Pena HF, Gennari SM: Molecular identification of Cryptosporidium spp. from fecal samples of felines, canines and bovines in the state of São Paulo, Brazil. Vet Parasitol. 2007, 150: 291-296. 10.1016/j.vetpar.2007.09.023.

  96. 96.

    Tolezano JE, Uliana SR, Taniguchi HH, Araújo MF, Barbosa JA, Barbosa JE, Floeter-Winter LM, Shaw JJ: The first records of Leishmania (Leishmania) amazonensis in dogs (Canis familiaris) diagnosed clinically as having canine visceral leishmaniasis from Araçatuba County, São Paulo State, Brazil. Vet Parasitol. 2007, 149: 280-284. 10.1016/j.vetpar.2007.07.008.

  97. 97.

    Volotão AC, Costa-Macedo LM, Haddad FS, Brandão A, Peralta JM, Fernandes O: Genotyping of Giardia duodenalis from human and animal samples from Brazil using beta-giardin gene: a phylogenetic analysis. Acta Trop. 2007, 102: 10-19. 10.1016/j.actatropica.2007.02.010.

  98. 98.

    Campos Filho PC, Barros LM, Campos JO, Braga VB, Cazorla IM, Albuquerque GR, Carvalho SM: Zoonotic parasites in dog feces at public squares in the municipality of Itabuna, Bahia, Brazil. Rev Bras Parasitol Vet. 2008, 17: 206-209.

  99. 99.

    Fernandes AB, Baêta BA, Filho WF, Massad FV, Rebouças FA, De Carvalho JB, Lopes CW: Relationship between companion animals and intestinal parasites in children at municipality of Seropédica, RJ. Rev Bras Parasitol Vet. 2008, 17 (Suppl 1): 296-300.

  100. 100.

    Katagiri S, Oliveira-Sequeira TC: Prevalence of dog intestinal parasites and risk perception of zoonotic infection by dog owners in São Paulo State, Brazil. Zoonoses Public Health. 2008, 55: 406-413. 10.1111/j.1863-2378.2008.01163.x.

  101. 101.

    Meireles P, Montiani-Ferreira F, Thomaz-Soccol V: Survey of giardiosis in household and shelter dogs from metropolitan areas of Curitiba, Paraná state, Southern Brazil. Vet Parasitol. 2008, 152: 242-248. 10.1016/j.vetpar.2007.12.025.

  102. 102.

    Oliveira Lima AN, da Silva SS, Herrera HM, Gama C, Cupolillo E, Jansen AM, Fernandes O: Trypanosoma evansi: molecular homogeneity as inferred by phenetical analysis of ribosomal internal transcribed spacers DNA of an eclectic parasite. Exp Parasitol. 2008, 118: 402-407. 10.1016/j.exppara.2007.10.003.

  103. 103.

    Rubini AS, dos Santos PK, Von Ah LV, O'Dwyer LH: Molecular and parasitological survey of Hepatozoon canis (Apicomplexa: Hepatozoidae) in dogs from rural area of São Paulo state, Brazil. Parasitol Res. 2008, 102: 895-899. 10.1007/s00436-007-0846-7.

  104. 104.

    Shigueru FJ, Garcia JL, Vidotto MC, Balarin MR, Fabretti AK, Gasparini MR, Coelho AL, Vidotto O: Occurrence and molecular characterization of Babesia species in a canine hospital population in the Londrina Region, Paraná State, Brazil. Rev Bras Parasitol Vet. 2008, 17 (Suppl 1): 277-283.

  105. 105.

    Torrico KJ, Santos KR, Martins T, Silva FM P e, Takahira RK, Lopes RS: Occurrence of gastrointestinal parasites in dogs and cats in the laboratory of routine of parasitic diseases FMVZ/Unesp-Botucatu, SP. Rev Bras Parasitol Vet. 2008, 17 (Suppl 1): 182-183.

  106. 106.

    Costa-Júnior LM, Ribeiro MF, Rembeck K, Rabelo EM, Zahler-Rinder M, Hirzmann J, Pfister K, Passos LM: Canine babesiosis caused by Babesia canis vogeli in rural areas of the State of Minas Gerais, Brazil and factors associated with its seroprevalence. Res Vet Sci. 2009, 86: 257-260. 10.1016/j.rvsc.2008.07.002.

  107. 107.

    Furtado AP, Do Carmo ES, Giese EG, Vallinoto AC, Lanfredi RM, Santos JN: Detection of dog filariasis in Marajo Island, Brazil by classical and molecular methods. Parasitol Res. 2009, 105: 1509-1515. 10.1007/s00436-009-1584-9.

  108. 108.

    Madeira MF, Sousa MA, Barros JH, Figueiredo FB, Fagundes A, Schubach A, DE Paula CC, Faissal BN, Fonseca TS, Thoma HK, Marzochi MC: Trypanosoma caninum n. sp. (Protozoa: Kinetoplastida) isolated from intact skin of a domestic dog (Canis familiaris) captured in Rio de Janeiro, Brazil. Parasitology. 2009, 136: 411-423. 10.1017/S003118200900554X.

  109. 109.

    O'Dwyer LH, Lopes VV, Rubini AS, Paduan Kdos S, Ribolla PE: Babesia spp. infection in dogs from rural areas of São Paulo State, Brazil. Rev Bras Parasitol Vet. 2009, 18: 23-26. 10.4322/rbpv.01802005.

  110. 110.

    Oliveira LP, Cardozo GP, Santos EV, Mansur MA, Donini IA, Zissou VG, Roberto PG, Marins M: Molecular analysis of the rRNA genes of Babesia spp and Ehrlichia canis detected in dogs from Ribeirão Preto, Brazil. Braz J Microbiol. 2009, 40: 238-240. 10.1590/S1517-83822009000200006.

  111. 111.

    Quaresma PF, Murta SM, Ferreira Ede C, Rocha-Lima AC, Xavier AA, Gontijo CM: Molecular diagnosis of canine visceral leishmaniasis: identification of Leishmania species by PCR-RFLP and quantification of parasite DNA by real-time PCR. Acta Trop. 2009, 111: 289-294. 10.1016/j.actatropica.2009.05.008.

  112. 112.

    Spolidorio MG, Labruna MB, Zago AM, Donatele DM, Caliari KM, Yoshinari NH: Hepatozoon canis infecting dogs in the State of Espírito Santo, southeastern Brazil. Vet Parasitol. 2009, 163: 357-361. 10.1016/j.vetpar.2009.05.002.

  113. 113.

    Dantas-Torres F, de Paiva-Cavalcanti M, Figueredo LA, Melo MF, Silva FJ, Silva AL, Almeida EL, Brandão-Filho SP: Cutaneous and visceral leishmaniasis in dogs from a rural community in northeastern Brazil. Vet Parasitol. 2010, 170: 313-317. 10.1016/j.vetpar.2010.02.019.

  114. 114.

    Gomes PV, Mundim MJ, Mundim AV, de Ávila DF, Guimarães EC, Cury MC: Occurrence of Hepatozoon sp. in dogs in the urban area originating from a municipality in southeastern Brazil. Vet Parasitol. 2010, 174: 155-161. 10.1016/j.vetpar.2010.07.020.

  115. 115.

    Sevá AP, Funada MR, Souza SO, Nava A, Richtzenhain LJ, Soares RM: Occurrence and molecular characterization of Cryptosporidium spp. isolated from domestic animals in a rural area surrounding Atlantic dry forest fragments in Teodoro Sampaio municipality, State of São Paulo, Brazil. Rev Bras Parasitol Vet. 2010, 19: 249-253. 10.1590/S1984-29612010000400011.

  116. 116.

    Coelho WM, Amarante AF, Apolinário Jde C, Coelho NM, Bresciani KD: Occurrence of Ancylostoma in dogs, cats and public places from Andradina city, São Paulo state, Brazil. Rev Inst Med Trop Sao Paulo. 2011, 53: 181-184.

  117. 117.

    Dias ES, Regina-Silva S, França-Silva JC, Paz GF, Michalsky EM, Araújo SC, Valadão JL, de Oliveira Lara-Silva F, de Oliveira FS, Pacheco RS, Fortes-Dias CL: Eco-epidemiology of visceral leishmaniasis in the urban area of Paracatu, state of Minas Gerais, Brazil. Vet Parasitol. 2011, 176: 101-111. 10.1016/j.vetpar.2010.11.014.

  118. 118.

    Duarte SC, Parente JA, Pereira M, Soares CM, Linhares GF: Phylogenetic characterization of Babesia canis vogeli in dogs in the state of Goiás, Brazil. Rev Bras Parasitol Vet. 2011, 20: 274-280. 10.1590/S1984-29612011000400004.

  119. 119.

    Soares JF, Girotto A, Brandão PE, Da Silva AS, França RT, Lopes ST, Labruna MB: Detection and molecular characterization of a canine piroplasm from Brazil. Vet Parasitol. 2011, 180: 203-208. 10.1016/j.vetpar.2011.03.024.

  120. 120.

    Costa LM, Zahler-Rinder M, Ribeiro MF, Rembeck K, Rabelo EM, Pfister K, Passos LM: Use of a Real Time PCR for detecting subspecies of Babesia canis. Vet Parasitol. 2012, 188: 160-163. 10.1016/j.vetpar.2012.03.015.

  121. 121.

    Eloy LJ, Lucheis SB: Hemoculture and polymerase chain reaction using primers TCZ1/TCZ2 for the diagnosis of canine and feline trypanosomiasis. ISRN Vet Sci. 2012, 2012: 419378-

  122. 122.

    Gonçalves AQ, Ascaso C, Santos I, Serra PT, Julião GR, Orlandi PP: Calodium hepaticum: household clustering transmission and the finding of a source of human spurious infection in a community of the Amazon region. PLoS Negl Trop Dis. 2012, 6: e1943-10.1371/journal.pntd.0001943.

  123. 123.

    Langoni H, Matteucci G, Medici B, Camossi LG, Richini-Pereira VB, Silva RC: Detection and molecular analysis of Toxoplasma gondii and Neospora caninum from dogs with neurological disorders. Rev Soc Bras Med Trop. 2012, 45: 365-368. 10.1590/S0037-86822012000300016.

  124. 124.

    Lemos TD, Cerqueira Ade M, Toma HK, Silva AV, Corrêa RG, Paludo GR, Massard CL, Almosny NR: Detection and molecular characterization of piroplasms species from naturally infected dogs in southeast Brazil. Rev Bras Parasitol Vet. 2012, 21: 137-142. 10.1590/S1984-29612012000200012.

  125. 125.

    Martins CM, Barros CC, Bier D, Marinho AP, Figueiredo JM, Hoffmann JL, Molento MB, Biondo AW: Dog parasite incidence and risk factors, from sampling after one-year interval, in Pinhais, Brazil. Rev Bras Parasitol Vet. 2012, 21: 101-106. 10.1590/S1984-29612012000200006.

  126. 126.

    Silva FM P e, Monobe MM, Lopes RS, Araujo JP: Molecular characterization of Giardia duodenalis in dogs from Brazil. Parasitol Res. 2012, 110: 325-334. 10.1007/s00436-011-2492-3.

  127. 127.

    Santana VL, Souza AP, Lima DASD, Araújo AL, Justiniano SV, Dantas RP, Guedes PMM, Melo MA: Clinical and laboratorial characterization of naturally infected Trypanosoma cruzi dogs in the northeastern semi-arid. Pesq Vet Bras. 2012, 32: 536-541. 10.1590/S0100-736X2012000600011.

  128. 128.

    Leça Júnior NF, Dos Anjos Almeida V, Santos Carvalho F, Rego Albuquerque G, Lessa Silva F: First report of Trypanosoma cruzi infection in naturally infected dogs from southern Bahia, Brazil. Rev Bras Parasitol Vet. in press

  129. 129.

    Morais RC, Gonçalves SC, Costa PL, da Silva KG, da Silva FJ, Silva RP, de Brito ME, Brandão-Filho SP, Dantas-Torres F, de Paiva-Cavalcanti M: Detection of Leishmania infantum in animals and their ectoparasites by conventional PCR and real time PCR. Exp Appl Acarol. 2013, 59: 473-481. 10.1007/s10493-012-9611-4.

  130. 130.

    Rocha FL, Roque AL, Arrais RC, Santos JP, Lima VS, Xavier SC, Cordeir-Estrela P, D'Andrea PS, Jansen AM: Trypanosoma cruzi TcI and TcII transmission among wild carnivores, small mammals and dogs in a conservation unit and surrounding areas, Brazil. Parasitology. 2013, 140: 160-170. 10.1017/S0031182012001539.

  131. 131.

    Labarthe N, Ferreira AM, Guerrero J, Newcomb K, Paes-de-Almeida E: Survey of Dirofilaria immitis (Leidy, 1856) in random source cats in metropolitan Rio de Janeiro, Brazil, with descriptions of lesions. Vet Parasitol. 1997, 71: 301-306. 10.1016/S0304-4017(97)00041-1.

  132. 132.

    Serra CM, Uchôa CM, Coimbra RA: Parasitological study with faecal samples of stray and domiciliated cats (Felis catus domesticus) from the Metropolitan Area of Rio de Janeiro, Brazil. Rev Soc Bras Med Trop. 2003, 36: 331-334.

  133. 133.

    Labarthe N, Serrão ML, Ferreira AM, Almeida NK, Guerrero J: A survey of gastrointestinal helminths in cats of the metropolitan region of Rio de Janeiro, Brazil. Vet Parasitol. 2004, 123: 133-139. 10.1016/j.vetpar.2004.06.002.

  134. 134.

    Coelho WM, do Amarante AF, de Soutello RV, Meireles MV, Bresciani KD: Occurrence of gastrointestinal parasites in fecal samples of cats in Andradina City, São Paulo. Rev Bras Parasitol Vet. 2009, 18: 46-49.

  135. 135.

    Verocai GG, Measures LN, Azevedo FD, Correia TR, Fernandes JI, Scott FB: Dioctophyme renale (Goeze, 1782) in the abdominal cavity of a domestic cat from Brazil. Vet Parasitol. 2009, 161: 342-344. 10.1016/j.vetpar.2009.01.032.

  136. 136.

    Sobrinho LS, Rossi CN, Vides JP, Braga ET, Gomes AA, de Lima VM, Perri SH, Generoso D, Langoni H, Leutenegger C, Biondo AW, Laurenti MD, Marcondes M: Coinfection of Leishmania chagasi with Toxoplasma gondii, Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) in cats from an endemic area of zoonotic visceral leishmaniasis. Vet Parasitol. 2012, 187: 302-306. 10.1016/j.vetpar.2012.01.010.

  137. 137.

    Ramos DG, Scheremeta RG, Oliveira AC, Sinkoc AL, Pacheco R de C: Survey of helminth parasites of cats from the metropolitan area of Cuiabá, Mato Grosso, Brazil. Rev Bras Parasitol Vet. 2013, 22: 201-206.

  138. 138.

    Perez RR, Rubini AS, O'Dwyer LH: The first report of Hepatozoon spp. (Apicomplexa, Hepatozoidae) in domestic cats from São Paulo state, Brazil. Parasitol Res. 2004, 94: 83-85. 10.1007/s00436-004-1167-8.

  139. 139.

    Savani ES, de Oliveira Camargo MC, de Carvalho MR, Zampieri RA, dos Santos MG, D'Auria SR, Shaw JJ, Floeter-Winter LM: The first record in the Americas of an autochthonous case of Leishmania (Leishmania) infantum chagasi in a domestic cat (Felix catus) from Cotia County, São Paulo State, Brazil. Vet Parasitol. 2004, 120: 229-233. 10.1016/j.vetpar.2004.01.008.

  140. 140.

    Schubach TM, Figueiredo FB, Pereira SA, Madeira MF, Santos IB, Andrade MV, Cuzzi T, Marzochi MC, Schubach A: American cutaneous leishmaniasis in two cats from Rio de Janeiro, Brazil: first report of natural infection with Leishmania (Viannia) braziliensis. Trans R Soc Trop Med Hyg. 2004, 98: 165-167. 10.1016/S0035-9203(03)00040-3.

  141. 141.

    Souza AI, Barros EM, Ishikawa E, Ilha IM, Marin GR, Nunes VL: Feline leishmaniasis due to Leishmania (Leishmania) amazonensis in Mato Grosso do Sul State, Brazil. Vet Parasitol. 2005, 128: 41-45. 10.1016/j.vetpar.2004.11.020.

  142. 142.

    Criado-Fornelio A, Ruas JL, Casado N, Farias NA, Soares MP, Müller G, Brumt JG, Berne ME, Buling-Saraña A, Barba-Carretero JC: New molecular data on mammalian Hepatozoon species (Apicomplexa: Adeleorina) from Brazil and Spain. J Parasitol. 2006, 92: 93-99. 10.1645/GE-464R.1.

  143. 143.

    Rubini AS, Dos Santos Paduan K, Perez RR, Ribolla PE, O'Dwyer LH: Molecular characterization of feline Hepatozoon species from Brazil. Vet Parasitol. 2006, 137: 168-171. 10.1016/j.vetpar.2005.12.008.

  144. 144.

    Coelho WM, Lima VM, Amarante AF, Langoni H, Pereira VB, Abdelnour A, Bresciani KD: Occurrence of Leishmania (Leishmania) chagasi in a domestic cat (Felis catus) in Andradina, São Paulo, Brazil: case report. Rev Bras Parasitol Vet. 2010, 19: 256-258. 10.1590/S1984-29612010000400013.

  145. 145.

    Coelho WM, Richini-Pereira VB, Langoni H, Bresciani KD: Molecular detection of Leishmania sp. in cats (Felis catus) from Andradina Municipality, São Paulo State, Brazil. Vet Parasitol. 2011, 176: 281-282. 10.1016/j.vetpar.2010.10.052.

  146. 146.

    de Bortoli CP, André MR, Braga Mdo S, Machado RZ: Molecular characterization of Hepatozoon sp. in cats from São Luís Island, Maranhão, Northeastern Brazil. Parasitol Res. 2011, 109: 1189-1192. 10.1007/s00436-011-2376-6.

  147. 147.

    Vides JP, Schwardt TF, Sobrinho LS, Marinho M, Laurenti MD, Biondo AW, Leutenegger C, Marcondes M: Leishmania chagasi infection in cats with dermatologic lesions from an endemic area of visceral leishmaniosis in Brazil. Vet Parasitol. 2011, 178: 22-28. 10.1016/j.vetpar.2010.12.042.

  148. 148.

    Maia LM, Cerqueira AM, de Barros Macieira D, de Souza AM, Moreira NS, da Silva AV, Messick JB, Ferreira RF, Almosny NR: Cytauxzoon felis and 'Candidatus Mycoplasma haemominutum' coinfection in a Brazilian domestic cat (Felis catus). Rev Bras Parasitol Vet. 2013, 22: 289-291.

  149. 149.

    Coura-Vital W, Marques MJ, Veloso VM, Roatt BM, Aguiar-Soares RD, Reis LE, Braga SL, Morais MH, Reis AB, Carneiro M: Prevalence and factors associated with Leishmania infantum infection of dogs from an urban area of Brazil as identified by molecular methods. PLoS Negl Trop Dis. 2011, 5: e1291-10.1371/journal.pntd.0001291.

  150. 150.

    Teles NM, Agostini MA, Bigeli JG, Noleto RV, Oliveira JD, de Oliveira Junior WD: Molecular and parasitological detection of Leishmania spp. in dogs caught in Palmas, TO, Brazil. Rev Bras Parasitol Vet. 2012, 21: 278-282. 10.1590/S1984-29612012000300017.

  151. 151.

    Tomaz-Soccol V, Castro EA, Navarro IT, de Farias MR, de Souza LM, Carvalho Y, Bispo S, Membrive NA, Minozzo JC, Truppel J, Bueno W, Luz E: Allochthonous cases of canine visceral leishmaniasis in Paraná, Brazil: epidemiological implications. Rev Bras Parasitol Vet. 2009, 18: 46-51.

  152. 152.

    Marcondes CB, Pirmez C, Silva ES, Laurentino-Silva V, Steindel M, Santos AJ, Smaniotto H, Silva CF, Schuck Neto VF, Donetto A: A survey of visceral leishmaniasis in dogs from Santa Maria and neighbouring municipalities, State of Rio Grande do Sul. Rev Soc Bras Med Trop. 2003, 36: 499-501. 10.1590/S0037-86822003000400011.

  153. 153.

    Salomón OD, Orellano PW: Lutzomyia longipalpis in Clorinda, Formosa province, an area of potential visceral leishmaniasis transmission in Argentina. Mem Inst Oswaldo Cruz. 2005, 100: 475-476.

  154. 154.

    Brazil RP, Caballero NN, Hamilton JG: Identification of the sex pheromone of Lutzomyia longipalpis (Lutz and Neiva, 1912) (Diptera: Psychodidae) from Asunción, Paraguay. Parasit Vectors. 2009, 2: 51-10.1186/1756-3305-2-51.

  155. 155.

    Salomón OD, Basmajdian Y, Fernández MS, Santini MS: Lutzomyia longipalpis in Uruguay: the first report and the potential of visceral leishmaniasis transmission. Mem Inst Oswaldo Cruz. 2011, 106: 381-382. 10.1590/S0074-02762011000300023.

  156. 156.

    Oliveira AG, Galati EA, de Oliveira O, de Oliveira GR, Espindola IA, Dorval ME, Brazil RP: Abundance of Lutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae) and urban transmission of visceral leishmaniasis in Campo Grande, state of Mato Grosso do Sul, Brazil. Mem Inst Oswaldo Cruz. 2006, 101: 869-874.

  157. 157.

    Souza GD, Santos E, Andrade Filho JD: The first report of the main vector of visceral leishmaniasis in America, Lutzomyia longipalpis (Lutz & Neiva) (Diptera: Psychodidae: Phlebotominae), in the state of Rio Grande do Sul, Brazil. Mem Inst Oswaldo Cruz. 2009, 104: 1181-1182. 10.1590/S0074-02762009000800017.

  158. 158.

    Loretti AP, Barros SS: Hemorrhagic disease in dogs infected with an unclassified intraendothelial piroplasm in southern Brazil. Vet Parasitol. 2005, 134: 193-213. 10.1016/j.vetpar.2005.07.011.

  159. 159.

    Silva AS, Martins DB, Soares JF, França RT: Canine rangeliosis: the need for differential diagnosis. Parasitol Res. 2013, 112: 1329-1332. 10.1007/s00436-012-3160-y.

  160. 160.

    Szabó MP, Pinter A, Labruna MB: Ecology, biology and distribution of spotted-fever tick vectors in Brazil. Front Cell Infect Microbiol. 2013, 3: 27-

  161. 161.

    Burlini L, Teixeira KR, Szabó MP, Famadas KM: Molecular dissimilarities of Rhipicephalus sanguineus (Acari: Ixodidae) in Brazil and its relation with samples throughout the world: is there a geographical pattern?. Exp Appl Acarol. 2010, 50: 361-374. 10.1007/s10493-009-9321-8.

  162. 162.

    Moraes-Filho J, Marcili A, Nieri-Bastos FA, Richtzenhain LJ, Labruna MB: Genetic analysis of ticks belonging to the Rhipicephalus sanguineus group in Latin America. Acta Trop. 2011, 117: 51-55. 10.1016/j.actatropica.2010.09.006.

  163. 163.

    Alves LC, de Almeida Silva LV, Faustino MA, McCall JW, Supakonderj P, Labarthe NW, Sanchez M, Caires O: Survey of canine heartworm in the city of Recife, Pernambuco, Brazil. Mem Inst Oswaldo Cruz. 1999, 94: 587-590. 10.1590/S0074-02761999000500004.

  164. 164.

    Brito AC, Vila-Nova MC, Martins Rocha DA, Gomes Costa L, de Almeida WA P, da Silva Viana L, Ramalho Lopes R, Fontes G, da Rocha EM, Regis L: Prevalence of canine filariasis by Dirofilaria immitis and Dipetalonema reconditum in Maceió, Alagoas State, Brazil. Cad Saude Publica. 2001, 17: 1497-504. 10.1590/S0102-311X2001000600034.

  165. 165.

    Linardi PM: Endoparasitos de Ctenocephalides felis felis (Siphonaptera: Pulicidae) em Belo Horizonte, MG. Biogeosciences. 2002, 64: 65-

  166. 166.

    Reifur L, Thomaz-Soccol V, Montiani-Ferreira F: Epidemiological aspects of filariosis in dogs on the coast of Paraná state, Brazil: with emphasis on Dirofilaria immitis. Vet Parasitol. 2004, 122: 273-286. 10.1016/j.vetpar.2004.05.017.

  167. 167.

    Avelar DM, Bussolotti AS, do Carmo A A, Ramos M M, Linardi PM: Endosymbionts of Ctenocephalides felis felis (Siphonaptera: Pulicidae) obtained from dogs captured in Belo Horizonte, Minas Gerais, Brazil. J Invertebr Pathol. 2007, 94: 149-152. 10.1016/j.jip.2006.10.001.

  168. 168.

    Dantas-Torres F, de Brito ME, Brandão-Filho SP: Seroepidemiological survey on canine leishmaniasis among dogs from an urban area of Brazil. Vet Parasitol. 2006, 140: 54-60. 10.1016/j.vetpar.2006.03.008.

  169. 169.

    Figueredo LA, Dantas-Torres F, de Faria EB, Gondim LF, Simões-Mattos L, Brandão-Filho SP, Mota RA: Occurrence of antibodies to Neospora caninum and Toxoplasma gondii in dogs from Pernambuco, Northeast Brazil. Vet Parasitol. 2008, 157: 9-13. 10.1016/j.vetpar.2008.07.009.

  170. 170.

    Santos JM, Dantas-Torres F, Mattos MR, Lino FR, Andrade LS, Souza RC, Brito FL, Brito ME, Brandão-Filho SP, Simões-Mattos L: Prevalence of anti-Leishmania spp antibodies in dogs from Garanhuns, in the middle scrub zone (Agreste) of Pernambuco. Rev Soc Bras Med Trop. 2010, 43: 41-45. 10.1590/S0037-86822010000100010.

  171. 171.

    Coelho WM, do Amarante AF, Apolinário JC, Coelho NM, de Lima VM, de Perri SH, de Bresciani KD: Seroepidemiology of Toxoplasma gondii, Neospora caninum, and Leishmania spp. infections and risk factors for cats from Brazil. Parasitol Res. 2011, 109: 1009-1013. 10.1007/s00436-011-2461-x.

  172. 172.

    Cardia DF, Camossi LG, Neto LD, Langoni H, Bresciani KD: Prevalence of Toxoplasma gondii and Leishmania spp. infection in cats from Brazil. Vet Parasitol. 2013, 197: 634-637. 10.1016/j.vetpar.2013.07.017.

  173. 173.

    Nogueira CI, Mesquita LP, Abreu CC, Nakagaki KY, Seixas JN, Bezerra PS, Rocha CM, Guimaraes AM, Peconick AP, Varaschin MS: Risk factors associated with seroprevalence of Neospora caninum in dogs from urban and rural areas of milk and coffee production in Minas Gerais state, Brazil. Epidemiol Infect. 2013, 141: 2286-2293. 10.1017/S0950268813000162.

  174. 174.

    Labarthe N, Serrão ML, Melo YF, de Oliveira SJ, Lourenço-de-Oliveira R: Mosquito frequency and feeding habits in an enzootic canine dirofilariasis area in Niterói, state of Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. 1998, 93: 145-154. 10.1590/S0074-02761998000200002.

  175. 175.

    Resende MC, Camargo MC, Vieira JR, Nobi RC, Porto MN, Oliveira CD, Pessanha JE, Cunha Mda C, Brandão ST: Seasonal variation of Lutzomyia longipalpis in Belo Horizonte, State of Minas Gerais. Rev Soc Bras Med Trop. 2006, 39: 51-55. 10.1590/S0037-86822006000100010.

  176. 176.

    Ximenes MF, Castellón EG, De Souza MF, Menezes AA, Queiroz JW, Macedo e Silva VP, Jerônimo SM: Effect of abiotic factors on seasonal population dynamics of Lutzomyia longipalpis (Diptera: Psychodidae) in northeastern Brazil. J Med Entomol. 2006, 43: 990-995. 10.1603/0022-2585(2006)43[990:EOAFOS]2.0.CO;2.

  177. 177.

    Oliveira AG, Galati EA, Fernandes CE, Dorval ME, Brazil RP: Seasonal variation of Lutzomyia longipalpis (Lutz & Neiva, 1912) (Diptera: Psychodidae: Phlebotominae) in endemic area of visceral leishmaniasis, Campo Grande, state of Mato Grosso do Sul, Brazil. Acta Trop. 2008, 105: 55-61. 10.1016/j.actatropica.2007.09.008.

  178. 178.

    Amóra SS, Bevilaqua CM, Dias EC, Feijó FM, Oliveira PG, Peixoto GC, Alves ND, Oliveira LM, Macedo IT: Monitoring of Lutzomyia longipalpis Lutz & Neiva, 1912 in an area of intense transmission of visceral leishmaniasis in Rio Grande do Norte, Northeast Brazil. Rev Bras Parasitol Vet. 2010, 19: 39-43.

  179. 179.

    Saraiva L, Andrade Filho JD, Falcão AL, de Carvalho DA, de Souza CM, Freitas CR, Gomes Lopes CR, Moreno EC, Melo MN: Phlebotominae fauna (Diptera: Psychodidae) in an urban district of Belo Horizonte, Brazil, endemic for visceral leishmaniasis: characterization of favored locations as determined by spatial analysis. Acta Trop. 2011, 117: 137-145. 10.1016/j.actatropica.2010.11.007.

  180. 180.

    Costa PL, Dantas-Torres F, da Silva FJ, Guimarães VC, Gaudêncio K, Brandão-Filho SP: Ecology of Lutzomyia longipalpis in an area of visceral leishmaniasis transmission in north-eastern Brazil. Acta Trop. 2013, 126: 99-102. 10.1016/j.actatropica.2013.01.011.

  181. 181.

    Reinhold-Castro KR, Fenelon VC, Rossi RM, Brito JE, Freitas JS, Teodoro U: Impact of control measures and dynamics of sand flies in southern Brazil. J Vector Ecol. 2013, 38: 63-68. 10.1111/j.1948-7134.2013.12009.x.

  182. 182.

    Silveira JA, Passos LM, Ribeiro MF: Population dynamics of Rhipicephalus sanguineus (Latrielle, 1806) in Belo Horizonte, Minas Gerais state, Brazil. Vet Parasitol. 2009, 161: 270-275. 10.1016/j.vetpar.2009.01.028.

  183. 183.

    Louly CCB, Fonseca IN, Oliveira VF, Linhares GFC, Menezes LB, Borges LMF: Seasonal dynamics of Rhipicephalus sanguineus (Acari: Ixodidae) in dogs from a police unit in Goiania, Goias, Brazil. Cienc Rural. 2007, 37: 464-469. 10.1590/S0103-84782007000200026.

  184. 184.

    Maia MG, Costa RT, Haddad JP, Passos LM, Ribeiro MF: Epidemiological aspects of canine babesiosis in the semiarid area of the state of Minas Gerais, Brazil. Prev Vet Med. 2007, 79: 155-162. 10.1016/j.prevetmed.2006.11.013.

  185. 185.

    Heukelbach J, Jackson A, Ariza L, Feldmeier H: Prevalence and risk factors of hookworm-related cutaneous larva migrans in a rural community in Brazil. Ann Trop Med Parasitol. 2008, 102: 53-61. 10.1179/136485908X252205.

  186. 186.

    Tiyo R, Guedes TA, Falavigna DL, Falavigna-Guilherme AL: Seasonal contamination of public squares and lawns by parasites with zoonotic potential in southern Brazil. J Helminthol. 2008, 82: 1-6.

  187. 187.

    Andresiuk V, Sardella N, Denegri G: Seasonal fluctuations in prevalence of dog intestinal parasites in public squares of Mar del Plata city, Argentina and its risk for humans. Rev Argent Microbiol. 2007, 39: 221-224.

  188. 188.

    Táparo CV, Perri SHV, Serrano ACM, Ishizaki MN, Costa TP, Amarante AFT, Bresciani KDS: Comparison between coproparasitological techniques for the diagnosis of helminth eggs or protozoa oocysts in dogs. Rev Bras Parasitol Vet. 2006, 15: 1-5.

  189. 189.

    Mandarino-Pereira A, de Souza FS, Lopes CW, Pereira MJ: Prevalence of parasites in soil and dog feces according to diagnostic tests. Vet Parasitol. 2010, 170: 176-181. 10.1016/j.vetpar.2010.02.007.

  190. 190.

    Katagiri S, Oliveira-Sequeira TC: Comparison of three concentration methods for the recovery of canine intestinal parasites from stool samples. Exp Parasitol. 2010, 126: 214-216. 10.1016/j.exppara.2010.04.027.

  191. 191.

    Gomes JF, Hoshino-Shimizu S, Dias LC, Araujo AJ, Castilho VL, Neves FA: Evaluation of a novel kit (TF-Test) for the diagnosis of intestinal parasitic infections. J Clin Lab Anal. 2004, 18: 132-138. 10.1002/jcla.20011.

  192. 192.

    Farias LN, Malgor R, Cassaravilla C, Bragança C, de la Rue ML: Echinococcosis in southern Brazil: efforts toward implementation of a control program in Santana do Livramento, Rio Grande do Sul. Rev Inst Med Trop Sao Paulo. 2004, 46: 153-156. 10.1590/S0036-46652004000300006.

  193. 193.

    Monteiro RM, Pena HF, Gennari SM, de Souza SO, Richtzenhain LJ, Soares RM: Differential diagnosis of oocysts of Hammondia-like organisms of dogs and cats by PCR-RFLP analysis of 70-kilodalton heat shock protein (HSP70) gene. Parasitol Res. 2008, 103: 235-238. 10.1007/s00436-008-0957-9.

  194. 194.

    Soares RM, Lopes EG, Keid LB, Sercundes MK, Martins J, Richtzenhain LJ: Identification of Hammondia heydorni oocysts by a heminested-PCR (hnPCR-AP10) based on the H. heydorni RAPD fragment AP10. Vet Parasitol. 2011, 175: 168-172. 10.1016/j.vetpar.2010.09.022.

  195. 195.

    Dantas-Torres F, Figueredo LA: Canine babesiosis: a Brazilian perspective. Vet Parasitol. 2006, 141: 197-203. 10.1016/j.vetpar.2006.07.030.

  196. 196.

    Trapp SM, Dagnone AS, Vidotto O, Freire RL, Amude AM, de Morais HS: Seroepidemiology of canine babesiosis and ehrlichiosis in a hospital population. Vet Parasitol. 2006, 140: 223-230. 10.1016/j.vetpar.2006.03.030.

  197. 197.

    Guimarães AM, Rocha CM, Oliveira TM, Rosado IR, Morais LG, Santos RR: Factors associated the seropositivity for Babesia, Toxoplasma, Neospora e Leishmania in dogs attended at nine veterinary clinics in the municipality of Lavras. MG. Rev Bras Parasitol Vet. 2009, 18 (Suppl 1): 49-53.

  198. 198.

    Furuta PI, Oliveira TM, Theixeira MC, Rocha AG, Machado RZ, Tinucci-Costa MG: Comparison between a soluble antigen-based ELISA and IFAT in detecting antibodies against Babesia canis in dogs. Rev Bras Parasitol Vet. 2009, 18: 41-45. 10.4322/rbpv.01803007.

  199. 199.

    Ramos R, Ramos C, Araújo F, Oliveira R, Souza I, Pimentel D, Galindo M, Santana M, Rosas E, Faustino M, Alves L: Molecular survey and genetic characterization of tick-borne pathogens in dogs in metropolitan Recife (north-eastern Brazil). Parasitol Res. 2010, 107: 1115-1120. 10.1007/s00436-010-1979-7.

  200. 200.

    Almeida AB, Sousa VR, Gasparetto ND, da Silva GF, Figueiredo FB, Dutra V, Nakazato L, Madeira MF: Canine visceral leishmaniasis: diagnostic approaches based on polymerase chain reaction employing different biological samples. Diagn Microbiol Infect Dis. 2013, 76: 321-324. 10.1016/j.diagmicrobio.2013.03.017.

  201. 201.

    Ferreira SA, Almeida GG, Silva SO, Vogas GP, Fujiwara RT, de Andrade AS, Melo MN: Nasal, oral and ear swabs for canine visceral leishmaniasis diagnosis: new practical approaches for detection of Leishmania infantum DNA. PLoS Negl Trop Dis. 2013, 7: e2150-10.1371/journal.pntd.0002150.

  202. 202.

    Paiva Cavalcanti M, Dantas-Torres F, da Cunha G, de Albuquerque S, Silva de Morais RC, de Brito ME, Otranto D, Brandão-Filho SP: Quantitative real time PCR assays for the detection of Leishmania (Viannia) braziliensis in animals and humans. Mol Cell Probes. 2013, 27: 122-128. 10.1016/j.mcp.2013.01.003.

  203. 203.

    Reis LE, Coura-Vital W, Roatt BM, Bouillet LE, Ker HG, de Brito RC F, Resende DD, Carneiro M, Giunchetti RC, Marques MJ, Carneiro CM, Reis AB: Molecular diagnosis of canine visceral leishmaniasis: a comparative study of three methods using skin and spleen from dogs with natural Leishmania infantum infection. Vet Parasitol. 2013, 197: 498-503. 10.1016/j.vetpar.2013.07.006.

  204. 204.

    Silva MA, Pedrosa Soares CR, Medeiros RA, Medeiros Z, de Melo FL: Optimization of single-tube nested PCR for the diagnosis of visceral leishmaniasis. Exp Parasitol. 2013, 134: 206-210. 10.1016/j.exppara.2013.03.003.

  205. 205.

    Madeira MF, de O Schubach A, Schubach TM, Pereira SA, Figueiredo FB, Baptista C, Leal CA, Melo CX, Confort EM, Marzochi MC: Post mortem parasitological evaluation of dogs seroreactive for Leishmania from Rio de Janeiro, Brazil. Vet Parasitol. 2006, 138: 366-370. 10.1016/j.vetpar.2006.01.059.

  206. 206.

    Silva DA, Madeira MF, Teixeira AC, de Souza CM, Figueiredo FB: Laboratory tests performed on Leishmania seroreactive dogs euthanized by the leishmaniasis control program. Vet Parasitol. 2011, 179: 257-261. 10.1016/j.vetpar.2011.01.048.

  207. 207.

    Cavalcanti A, Lobo R, Cupolillo E, Bustamante F, Porrozzi R: Canine cutaneous leishmaniasis caused by neotropical Leishmania infantum despite of systemic disease: a case report. Parasitol Int. 2012, 61: 738-740. 10.1016/j.parint.2012.05.002.

  208. 208.

    Souza AI, Nunes VLB, Borralho VM, Ishikawa EAY: Domestic feline cutaneous leishmaniasis in the municipality of Ribas do Rio Pardo, Mato Grosso do Sul state, Brazil: a case report. J Venom Anim Toxins incl Trop Dis. 2009, 15: 359-365.

  209. 209.

    Demeler J, Ramünke S, Wolken S, Ianiello D, Rinaldi L, Gahutu JB, Cringoli G, von Samson-Himmelstjerna G, Krücken J: Discrimination of gastrointestinal nematode eggs from crude fecal egg preparations by inhibitor-resistant conventional and real-time PCR. PLoS One. 2013, 8: e61285-10.1371/journal.pone.0061285.

  210. 210.

    Deplazes P, van Knapen F, Schweiger A, Overgaauw PA: Role of pet dogs and cats in the transmission of helminthic zoonoses in Europe, with a focus on echinococcosis and toxocarosis. Vet Parasitol. 2011, 182: 41-53. 10.1016/j.vetpar.2011.07.014.

  211. 211.

    Lucio-Forster A, Liotta JL, Yaros JP, Briggs KR, Mohammed HO, Bowman DD: Morphological differentiation of eggs of Ancylostoma caninum, Ancylostoma tubaeforme, and Ancylostoma braziliense from dogs and cats in the United States. J Parasitol. 2012, 98: 1041-1044. 10.1645/GE-2928.1.

  212. 212.

    Taylor MA: Recent developments in ectoparasiticides. Vet J. 2001, 161: 253-268. 10.1053/tvjl.2000.0549.

  213. 213.

    Wall R: Ectoparasites: future challenges in a changing world. Vet Parasitol. 2007, 148: 62-74. 10.1016/j.vetpar.2007.05.011.

  214. 214.

    Pollmeier M, Pengo G, Jeannin P, Soll M: Evaluation of the efficacy of fipronil formulations in the treatment and control of biting lice, Trichodectes canis (De Geer, 1778) on dogs. Vet Parasitol. 2002, 107: 127-136. 10.1016/S0304-4017(02)00090-0.

  215. 215.

    Stanneck D, Kruedewagen EM, Fourie JJ, Horak IG, Davis W, Krieger KJ: Efficacy of an imidacloprid/flumethrin collar against fleas, ticks, mites and lice on dogs. Parasit Vectors. 2012, 5: 102-10.1186/1756-3305-5-102.

  216. 216.

    Kužner J, Turk S, Grace S, Soni-Gupta J, Fourie JJ, Marchiondo AA, Rugg D: Confirmation of the efficacy of a novel fipronil spot-on for the treatment and control of fleas, ticks and chewing lice on dogs. Vet Parasitol. 2013, 193: 245-251. 10.1016/j.vetpar.2012.11.006.

  217. 217.

    Serra-Freire NM, Benigno RNM, Oliveira SA, Lopes LMS, Galvão G: Lynxacarus radovskyi - diagnostic and treatment in cats from the Metropolitan region of Belem City, Para State. Rev Universidade Rural, Série Ciências da Vida. 2002, 22: 57-60.

  218. 218.

    Franco MB, Hamann W: Doramectin in the treatment of dogs with sarcoptic mange and gastrintestinal nematodes. Arch Vet Sci. 2004, 9: 23-29.

  219. 219.

    Silva RPB, Belettini ST, Stel RF, Martins LA, Pachaly JR: Canine dermodicosis and new treatment perspectives: review. Arq Cienc Vet Zool Unipar. 2008, 11: 139-151.

  220. 220.

    Otranto D, Wall R: New strategies for the control of arthropod vectors of disease in dogs and cats. Med Vet Entomol. 2008, 22: 291-302. 10.1111/j.1365-2915.2008.00741.x.

  221. 221.

    Paz GF, Labruna MB, Leite RC: Drop off rhythm of Rhipicephalus sanguineus (Acari: Ixodidae) of artificially infested dogs. Rev Bras Parasitol Vet. 2008, 17: 139-144.

  222. 222.

    Blagburn BL, Dryden MW: Biology, treatment, and control of flea and tick infestations. Vet Clin North Am Small Anim Pract. 2009, 39: 1173-1200. 10.1016/j.cvsm.2009.07.001.

  223. 223.

    Oliveira Lima JW, de Góes Cavalcanti LP, Pontes RJ, Heukelbach J: Survival of Betta splendens fish (Regan, 1910) in domestic water containers and its effectiveness in controlling Aedes aegypti larvae (Linnaeus, 1762) in Northeast Brazil. Trop Med Int Health. 2010, 15: 1525-1532. 10.1111/j.1365-3156.2010.02658.x.

  224. 224.

    Barbosa RM, Regis LN: Monitoring temporal fluctuations of Culex quinquefasciatus using oviposition traps containing attractant and larvicide in an urban environment in Recife, Brazil. Mem Inst Oswaldo Cruz. 2011, 106: 451-415. 10.1590/S0074-02762011000400011.

  225. 225.

    da Saúde M: Manual de vigilância e controle da leishmaniose visceral. 2006, Brasília: Ministério da Saúde

  226. 226.

    da Saúde M: Manual de Vigilância da leishmaniose tegumentar americana. 2007, Brasília: Ministério da Saúde, 2a

  227. 227.

    Alexander B, Barros VC, de Souza SF, Barros SS, Teodoro LP, Soares ZR, Gontijo NF, Reithinger R: Susceptibility to chemical insecticides of two Brazilian populations of the visceral leishmaniasis vector Lutzomyia longipalpis (Diptera: Psychodidae). Trop Med Int Health. 2009, 14: 1272-1277. 10.1111/j.1365-3156.2009.02371.x.

  228. 228.

    Belinato TA, Martins AJ, Valle D: Fitness evaluation of two Brazilian Aedes aegypti field populations with distinct levels of resistance to the organophosphate temephos. Mem Inst Oswaldo Cruz. 2012, 107: 916-922. 10.1590/S0074-02762012000700013.

  229. 229.

    Courtenay O, Gillingwater K, Gomes PA, Garcez LM, Davies CR: Deltamethrin-impregnated bednets reduce human landing rates of sandfly vector Lutzomyia longipalpis in Amazon households. Med Vet Entomol. 2007, 21: 168-176. 10.1111/j.1365-2915.2007.00678.x.

  230. 230.

    Araujo JM, Araújo JV, Braga FR, Araújo DM, Ferreira SR, Soares FE, Benjamin LA: Survival of Pochonia chlamydosporia in the gastrointestinal tract of experimentally treated dogs. Res Vet Sci. 2012, 93: 803-806. 10.1016/j.rvsc.2011.10.019.

  231. 231.

    Otranto D, Dantas-Torres F: The prevention of canine leishmaniasis and its impact on public health. Trends Parasitol. 2013, 29: 339-345. 10.1016/

  232. 232.

    Dantas-Torres F, Latrofa MS, Weigl S, Tarallo VD, Lia RP, Otranto D: Hepatozoon canis infection in ticks during spring and summer in Italy. Parasitol Res. 2012, 110: 695-698. 10.1007/s00436-011-2544-8.

  233. 233.

    Giannelli A, Ramos RA, Di Paola G, Mencke N, Dantas-Torres F, Baneth G, Otranto D: Transstadial transmission of Hepatozoon canis from larvae to nymphs of Rhipicephalus sanguineus. Vet Parasitol. 2013, 196: 1-5. 10.1016/j.vetpar.2013.02.017.

  234. 234.

    Dantas-Torres F: Canine leishmaniosis in South America. Parasit Vectors. 2009, 2 (Suppl 1): S1-10.1186/1756-3305-2-S1-S1.

  235. 235.

    Bongiorno G, Paparcone R, Manzillo VF, Oliva G, Cuisinier AM, Gradoni L: Vaccination with LiESP/QA-21 (CaniLeish®) reduces the intensity of infection in Phlebotomus perniciosus fed on Leishmania infantum infected dogs-A preliminary xenodiagnosis study. Vet Parasitol. 2013, 197: 691-695. 10.1016/j.vetpar.2013.05.008.

  236. 236.

    Otranto D, de Caprariis D, Lia RP, Tarallo V, Lorusso V, Testini G, Dantas-Torres F, Latrofa S, Diniz PP, Mencke N, Maggi RG, Breitschwerdt E, Capelli G, Stanneck D: Prevention of endemic canine vector-borne diseases using imidacloprid 10% and permethrin 50% in young dogs: a longitudinal field study. Vet Parasitol. 2010, 172: 323-332. 10.1016/j.vetpar.2010.05.017.

  237. 237.

    Dantas-Torres F, Capelli G, Giannelli A, Ramos RA, Lia RP, Cantacessi C, de Caprariis D, De Tommasi AS, Latrofa MS, Lacasella V, Tarallo VD, Di Paola G, Qurollo B, Breitschwerdt E, Stanneck D, Otranto D: Efficacy of an imidacloprid/flumethrin collar against fleas, ticks and tick-borne pathogens in dogs. Parasit Vectors. 2013, 6: 245-10.1186/1756-3305-6-245.

  238. 238.

    Otranto D, Dantas-Torres F, de Caprariis D, Di Paola G, Tarallo VD, Latrofa MS, Lia RP, Annoscia G, Breitshwerdt EB, Cantacessi C, Capelli G, Stanneck D: Prevention of canine leishmaniosis in a hyper-endemic area using a combination of 10% imidacloprid/4.5% flumethrin. PLoS One. 2013, 8: e56374-10.1371/journal.pone.0056374.

  239. 239.

    Beugnet F, Franc M: Insecticide and acaricide molecules and/or combinations to prevent pet infestation by ectoparasites. Trends Parasitol. 2012, 28: 267-279. 10.1016/

  240. 240.

    Beugnet F, Delport P, Luus H, Crafford D, Fourie J: Preventive efficacy of Frontline(®) Combo and Certifect(®) against Dipylidium caninum infestation of cats and dogs using a natural flea (Ctenocephalides felis) infestation model. Parasite. 2013, 20: 7-

  241. 241.

    Fourie JJ, Ollagnier C, Beugnet F, Luus HG, Jongejan F: Prevention of transmission of Ehrlichia canis by Rhipicephalus sanguineus ticks to dogs treated with a combination of fipronil, amitraz and (S)-methoprene (CERTIFECT®). Vet Parasitol. 2013, 193: 223-228. 10.1016/j.vetpar.2012.12.009.

  242. 242.

    Dantas-Torres F, Figueredo LA, Brandão-Filho SP: Rhipicephalus sanguineus (Acari: Ixodidae), the brown dog tick, parasitizing humans in Brazil. Rev Soc Bras Med Trop. 2006, 39: 64-67. 10.1590/S0037-86822006000100012.

  243. 243.

    Guglielmone AA, Beati L, Barros-Battesti DM, Labruna MB, Nava S, Venzal JM, Mangold AJ, Szabó MP, Martins JR, González-Acuña D, Estrada-Peña A: Ticks (Ixodidae) on humans in South America. Exp Appl Acarol. 2006, 40: 83-100. 10.1007/s10493-006-9027-0.

  244. 244.

    Louly CCB, Fonseca IN, Oliveira VF, Borges LMF: Occurrence of Rhipicephalus sanguineus in workers of veterinary clinics and kennels from Goiânia county, Goiás, Brazil. Cienc Anim Bras. 2006, 7: 103-106.

  245. 245.

    Szabó MP, Labruna MB, Castagnolli KC, Garcia MV, Pinter A, Veronez VA, Magalhães GM, Castro MB, Vogliotti A: Ticks (Acari: Ixodidae) parasitizing humans in an Atlantic rainforest reserve of Southeastern Brazil with notes on host suitability. Exp Appl Acarol. 2006, 39: 339-346. 10.1007/s10493-006-9013-6.

  246. 246.

    Serra-Freire NM: Occurrence of ticks (Acari: Ixodidae) on human hosts, in three municipalities in the State of Pará, Brazil. Rev Bras Parasitol Vet. 2010, 19: 141-147. 10.1590/S1984-29612010000300003.

  247. 247.

    Borsoi ABP, Serra-Freire NM: Parasitic relations between human beings and ticks in the Volta Redonda city, state of Rio de Janeiro, Brazil. Rev UNIABEU. 2012, 5: 306-317.

  248. 248.

    Dantas-Torres F: Rocky Mountain spotted fever. Lancet Infect Dis. 2007, 7: 724-732. 10.1016/S1473-3099(07)70261-X.

  249. 249.

    Perez M, Bodor M, Zhang C, Xiong Q, Rikihisa Y: Human infection with Ehrlichia canis accompanied by clinical signs in Venezuela. Ann N Y Acad Sci. 2006, 1078: 110-117. 10.1196/annals.1374.016.

  250. 250.

    Vieira RF, Vieira TS, Nascimento DA, Martins TF, Krawczak FS, Labruna MB, Chandrashekar R, Marcondes M, Biondo AW, Vidotto O: Serological survey of Ehrlichia species in dogs, horses and humans: zoonotic scenery in a rural settlement from southern Brazil. Rev Inst Med Trop Sao Paulo. 2013, 55: 335-340. 10.1590/S0036-46652013000500007.

  251. 251.

    Saito TB, Cunha-Filho NA, Pacheco RC, Ferreira F, Pappen FG, Farias NA, Larsson CE, Labruna MB: Canine infection by rickettsiae and ehrlichiae in southern Brazil. Am J Trop Med Hyg. 2008, 79: 102-108.

  252. 252.

    Santos F, Coppede JS, Pereira AL, Oliveira LP, Roberto PG, Benedetti RB, Zucoloto LB, Lucas F, Sobreira L, Marins M: Molecular evaluation of the incidence of Ehrlichia canis, Anaplasma platys and Babesia spp. in dogs from Ribeirão Preto, Brazil. Vet J. 2009, 179: 145-148. 10.1016/j.tvjl.2007.08.017.

  253. 253.

    Silva JN, Almeida AB, Boa Sorte Eda C, Freitas AG, Santos LG, Aguiar DM, Sousa VR: Seroprevalence anti-Ehrlichia canis antibodies in dogs of Cuiabá, Mato Grosso. Rev Bras Parasitol Vet. 2010, 19: 108-111. 10.4322/rbpv.01902008.

  254. 254.

    Souza BM, Leal DC, Barboza DC, Uzêda RS, De Alcântara AC, Ferreira F, Labruna MB: Prevalence of ehrlichial infection among dogs and ticks in Northeastern Brazil. Rev Bras Parasitol Vet. 2010, 19: 89-93. 10.4322/rbpv.01902004.

  255. 255.

    Aguiar DM, Cavalcante GT, Pinter A, Gennari SM, Camargo LM, Labruna MB: Prevalence of Ehrlichia canis (Rickettsiales: Anaplasmataceae) in dogs and Rhipicephalus sanguineus (Acari: Ixodidae) ticks from Brazil. J Med Entomol. 2007, 44: 126-132. 10.1603/0022-2585(2007)44[126:POECRA]2.0.CO;2.

  256. 256.

    Dantas-Torres F: The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): from taxonomy to control. Vet Parasitol. 2008, 152: 173-185. 10.1016/j.vetpar.2007.12.030.

  257. 257.

    Limongi JE, Silva JJ, Paula MBC, Mendes J: Epidemiologic aspects of flea infestations in the urban area of Uberlândia, Minas Gerais, 2007–2010. Epidemiol Serv Saude. 2013, 22: 285-294. 10.5123/S1679-49742013000200010.

  258. 258.

    Oliveira RP, Galvão MA, Mafra CL, Chamone CB, Calic SB, Silva SU, Walker DH: Rickettsia felis in Ctenocephalides spp. fleas, Brazil. Emerg Infect Dis. 2002, 8: 317-319. 10.3201/eid0803.010301.

  259. 259.

    Parola P: Rickettsia felis: from a rare disease in the USA to a common cause of fever in sub-Saharan Africa. Clin Microbiol Infect. 2011, 17: 996-1000. 10.1111/j.1469-0691.2011.03516.x.

  260. 260.

    Traversa D: Pet roundworms and hookworms: a continuing need for global worming. Parasit Vectors. 2012, 5: 91-10.1186/1756-3305-5-91.

  261. 261.

    Vidal JE, Sztajnbok J, Seguro AC: Eosinophilic meningoencephalitis due to Toxocara canis: case report and review of the literature. Am J Trop Med Hyg. 2003, 69: 341-343.

  262. 262.

    Moreira-Silva SF, Rodrigues MG, Pimenta JL, Gomes CP, Freire LH, Pereira FE: Toxocariasis of the central nervous system: with report of two cases. Rev Soc Bras Med Trop. 2004, 37: 169-174. 10.1590/S0037-86822004000200011.

  263. 263.

    Musso C, Castelo JS, Tsanaclis AM, Pereira FE: Prevalence of Toxocara-induced liver granulomas, detected by immunohistochemistry, in a series of autopsies at a Children's Reference Hospital in Vitoria, ES, Brazil. Virchows Arch. 2007, 450: 411-417. 10.1007/s00428-007-0388-5.

  264. 264.

    Schuster A, Lesshafft H, Reichert F, Talhari S, de Oliveira SG, Ignatius R, Feldmeier H: Hookworm-related cutaneous larva migrans in northern Brazil: resolution of clinical pathology after a single dose of ivermectin. Clin Infect Dis. 2013, 57: 1155-1157. 10.1093/cid/cit440.

  265. 265.

    Fragoso RP, Monteiro MB, Lemos EM, Pereira FE: Anti-Toxocara antibodies detected in children attending elementary school in Vitoria, State of Espírito Santo, Brazil: prevalence and associated factors. Rev Soc Bras Med Trop. 2011, 44: 461-466. 10.1590/S0037-86822011000400012.

  266. 266.

    Souza RF, Dattoli VC, Mendonça LR, Jesus JR, Baqueiro T, Santana Cde C, Santos NM, Barrouin-Melo SM, Alcantara-Neves NM: Prevalence and risk factors of human infection by Toxocara canis in Salvador, State of Bahia, Brazil. Rev Soc Bras Med Trop. 2011, 44: 516-519. 10.1590/S0037-86822011000400024.

  267. 267.

    Mattia S, Colli CM, Adami CM, Guilherme GF, Nishi L, Rubinsky-Elefant G, Marchioro AA, Gomes ML, Falavigna-Guilherme AL: Seroprevalence of Toxocara infection in children and environmental contamination of urban areas in Paraná State, Brazil. J Helminthol. 2012, 86: 440-445. 10.1017/S0022149X11000666.

  268. 268.

    Mendonça LR, Veiga RV, Dattoli VC, Figueiredo CA, Fiaccone R, Santos J, Cruz ÁA, Rodrigues LC, Cooper PJ, Pontes-de-Carvalho LC, Barreto ML, Alcantara-Neves NM: Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. PLoS Negl Trop Dis. 2012, 6: e1886-10.1371/journal.pntd.0001886.

  269. 269.

    Schoenardie ER, Scaini CJ, Brod CS, Pepe MS, Villela MM, McBride AJ, Borsuk S, Berne ME: Seroprevalence of Toxocara infection in children from southern Brazil. J Parasitol. 2013, 99: 537-539. 10.1645/GE-3182.

  270. 270.

    Capuano DM, Rocha GM: Environmental contamination by Toxocara sp. eggs in Ribeirão Preto, São Paulo State, Brazil. Rev Inst Med Trop Sao Paulo. 2005, 47: 223-226. 10.1590/S0036-46652005000400009.

  271. 271.

    Cassenote AJ, Pinto Neto JM, Lima-Catelani AR, Ferreira AW: Soil contamination by eggs of soil-transmitted helminths with zoonotic potential in the town of Fernandópolis, State of São Paulo, Brazil, between 2007 and 2008. Rev Soc Bras Med Trop. 2011, 44: 371-374. 10.1590/S0037-86822011005000026.

  272. 272.

    Gallina T, Silva MA, Castro LL, Wendt EW, Villela MM, Berne ME: Presence of eggs of Toxocara spp. and hookworms in a student environment in Rio Grande do Sul, Brazil. Rev Bras Parasitol Vet. 2011, 20: 176-177. 10.1590/S1984-29612011000200016.

  273. 273.

    Marques JP, Guimarães CR, Boas AV, Carnaúba PU, Moraes J: Contamination of public parks and squares from Guarulhos (São Paulo State, Brazil) by Toxocara spp. and Ancylostoma spp. Rev Inst Med Trop Sao Paulo. 2012, 54: 267-271. 10.1590/S0036-46652012000500006.

  274. 274.

    Marchioro AA, Colli CM, Ferreira EC, Tiyo R, Mattia S, de Souza WF, Falavigna-Guilherme AL: Identification of public areas with potential toxocariasis transmission risk using Geographical Information Systems. Acta Parasitol. 2013, 58: 328-333. 10.2478/s11686-013-0142-x.

  275. 275.

    Artigas PT, Araújo P, Romiti N, Ruivo M: Sobre um caso de parasitismo humano por Lagochilascaris minor Leiper, 1909, no Estado de São Paulo, Brasil. Rev Inst Med Trop Sao Paulo. 1968, 10: 78-83.

  276. 276.

    Veloso MG, Faria MC, de Freitas JD, Moraes MA, Gorini DF, de Mendonça JL: Human lagochilascariasis. 3 cases encountered in the Federal District, Brazil. Rev Inst Med Trop Sao Paulo. 1992, 34: 587-591. 10.1590/S0036-46651992000600014.

  277. 277.

    Aguilar-Nascimento JE, Silva GM, Tadano T, Valadares Filho M, Akiyama AM, Castelo A: Infection of the soft tissue of the neck due to Lagochilascaris minor. Trans R Soc Trop Med Hyg. 1993, 87: 198-10.1016/0035-9203(93)90491-8.

  278. 278.

    Vieira MA, de Oliveira JA, Ferreira LS, de Oliveira V, Barbosa CA: A case report of human lagochilascariasis coming from Pará State, Brazil. Rev Soc Bras Med Trop. 2000, 33: 87-90. 10.1590/S0037-86822000000100014.

  279. 279.

    Aquino RT, Magliari ME, Vital Filho J, Silva MA, Lima CA, Rocha AJ, Silva CJ, Rewin JA, Nahas TR, Chieffi PP: Lagochilascariasis leading to severe involvement of ocular globes, ears and meninges. Rev Inst Med Trop Sao Paulo. 2008, 50: 355-358. 10.1590/S0036-46652008000600009.

  280. 280.

    Palheta-Neto FX, Leão RNQ, Neto HF, Tomita S, Lima MAMT, Pezzin-Palheta AC: Contribution to the study of human lagochilascariasis. Rev Bras Otorrinolaringol. 2002, 68: 101-105.

  281. 281.

    Amato JF, Grisi L, Pimentel Neto M: Two cases of fistulated abscesses caused by Lagochilascaris major in the domestic cat. Mem Inst Oswaldo Cruz. 1990, 85: 471-473. 10.1590/S0074-02761990000400013.

  282. 282.

    Sudré AP, Uchôa F, Brener B: Lagochilascariasis in a housecat and the potential risk for human disease. Braz J Infect Dis. 2012, 16: 111-112.

  283. 283.

    Faccio L, Oliveira CB, Denardin CA, Tonin AA, Gressler LT, Dalla Rosa L, Sampaio LC, Stainki DR, Monteiro SG: Case report: Feline infection by Lagochilascaris sp. in the State of Rio Grande do Sul, Brazil. Vet Parasitol. 2013, 196: 541-543. 10.1016/j.vetpar.2013.03.006.

  284. 284.

    Barbosa CAL, Barbosa AP, Campos DMB: Domestic cat (Felis catus domesticus) as a possible reservoir of Lagochilascaris minor Leiper, 1909. Rev Patol Trop. 2005, 34: 205-211.

  285. 285.

    Moura MQ, Jeske S, Gallina T, Borsuk S, Berne ME, Villela MM: First report of Lagochilascaris (Nematoda: Ascarididae) eggs in a public park in Southern Brazil. Vet Parasitol. 2012, 184: 359-361. 10.1016/j.vetpar.2011.09.019.

  286. 286.

    Marinho RP, Neves DP: Dipylidium caninum (Dilepididae-Cestoda). Report of 2 human cases. Rev Inst Med Trop Sao Paulo. 1979, 21: 266-268.

  287. 287.

    Lemos CH, Oliveira CR: Infestação humana pelo Dipylidium caninum. Rev Soc Bras Med Trop. 1985, 18: 267-268. 10.1590/S0037-86821985000400012.

  288. 288.

    Maia MA, Campos DMB, Damasceno FA: Dipylidium caninum (Cestoda-Dilepididae). Report of one human case in Goiânia, Goiás, Brazil. Rev Patol Trop. 1991, 20: 7-12.