Glennon EKK, Adams LG, Hicks DR, Dehesh K, Luckhart S. Supplementation with abscisic acid reduces malaria disease severity and parasite transmission. Am J Trop Med Hyg. 2016;96:1266–75.
Article
Google Scholar
Pakpour N, Riehle MA, Luckhart S. Effects of ingested vertebrate-derived factors on insect immune responses. Curr Opin Insect Sci. 2014;3:1–5.
Article
PubMed
PubMed Central
Google Scholar
Luckhart S, Pakpour N, Giulivi C. Host-pathogen interactions in malaria: cross-kingdom signaling and mitochondrial regulation. Curr Opin Immunol. 2015;36:73–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pakpour N, Akman-Anderson L, Vodovotz Y, Luckhart S. The effects of ingested mammalian blood factors on vector arthropod immunity and physiology. Microbes Infect. 2013;15:243–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brady OJ, Godfray HC, Tatem AJ, Gething PW, Cohen JM, McKenzie FE, et al. Vectorial capacity and vector control: reconsidering sensitivity to parameters for malaria elimination. Trans R Soc Trop Med Hyg. 2016;110:107–17.
Article
PubMed
PubMed Central
Google Scholar
Bruzzone S, Bodrato N, Usai C, Guida L, Moreschi I, Nano R, et al. Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger. J Biol Chem. 2008;283:32188–97.
Article
CAS
PubMed
Google Scholar
Kang MA, Mott TM, Tapley EC, Lewis EE, Luckhart S. Insulin regulates aging and oxidative stress in Anopheles stephensi. J Exp Biol. 2008;211:741–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pakpour N, Corby-Harris V, Green GP, Smithers HM, Cheung KW, Riehle MA, Luckhart S. Ingested human insulin inhibits the mosquito NF-κB-dependent immune response to Plasmodium falciparum. Infect Immun. 2012;80:2141–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Drexler A, Nuss A, Hauck E, Glennon E, Cheung K, Brown M, Luckhart S. Human IGF1 extends lifespan and enhances resistance to Plasmodium falciparum infection in the malaria vector Anopheles stephensi. J Exp Biol. 2013;216:208–17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hauck ES, Antonova-Koch Y, Drexler A, Pietri J, Pakpour N, Liu D, et al. Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. Microbes Infect. 2013;15:775–87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Drexler AL, Pietri JE, Pakpour N, Hauck E, Wang B, Glennon EK, et al. Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi. PLoS Pathog. 2014;10:e1004231.
Article
PubMed
PubMed Central
Google Scholar
Pietri JE, Pietri EJ, Potts R, Riehle MA, Luckhart S. Plasmodium falciparum suppresses the host immune response by inducing the synthesis of insulin-like peptides (ILPs) in the mosquito Anopheles stephensi. Dev Comp Immunol. 2015;53:134–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pietri JE, Pakpour N, Napoli E, Song G, Pietri E, Potts R, et al. Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism. Biochem J. 2016;473:3487–503.
Article
PubMed
Google Scholar
Luckhart S, Giulivi C, Drexler AL, Antonova-Koch Y, Sakaguchi D, Napoli E, et al. Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host. PLoS Pathog. 2013;9:e1003180.
Article
PubMed
PubMed Central
Google Scholar
de Zelicourt A, Colcombet J, Hirt H. The role of MAPK modules and ABA during abiotic stress signaling. Trends Plant Sci. 2016;21:677–85.
Article
PubMed
Google Scholar
Woo HR, Kim HJ, Nam HG, Lim PO. Plant leaf senescence and death - regulation by multiple layers of control and implications for aging in general. J Cell Sci. 2013;126:4823–33.
Article
CAS
PubMed
Google Scholar
Berkowitz O, De Clercq I, Van Breusegem F, Whelan J. Interaction between hormonal and mitochondrial signalling during growth, development and in plant defence responses. Plant Cell Environ. 2016;39:1127–39.
Article
CAS
PubMed
Google Scholar
Colombatti F, Gonzalez DH, Welchen E. Plant mitochondria under pathogen attack: a sigh of relief or a last breath? Mitochondrion. 2014;19:238–44.
Article
CAS
PubMed
Google Scholar
Fuchs R, Kopischke M, Klapprodt C, Hause G, Meyer AJ, Schwarzländer M, et al. Immobilized subpopulations of leaf epidermal mitochondria mediate PENETRATION2-dependent pathogen entry control in Arabidopsis. Plant Cell. 2016;28:130–45.
PubMed
Google Scholar
Wang B, Pakpour N, Napoli E, Drexler A, Glennon EK, Surachetpong W, et al. Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. Parasit Vectors. 2015;8:424.
Article
PubMed
PubMed Central
Google Scholar
Surachetpong W, Singh N, Cheung KW, Luckhart S. MAPK ERK signaling regulates the TGF-beta1-dependent mosquito response to Plasmodium falciparum. PLoS Pathog. 2009;5:e1000366.
Article
PubMed
PubMed Central
Google Scholar
Lee J, Mira-Arbibe L, Ulevitch RJ. TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide. J Leukoc Biol. 2000;68:909–15.
CAS
PubMed
Google Scholar
Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005;6:1087–95.
Article
CAS
PubMed
Google Scholar
Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005;19:2668–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lim J. Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor (s), PhD dissertation. Blackburg, VA: Virginia Polytechnical Institute; 2004. https://theses.lib.vt.edu/theses/available/etd-11082004-023754/
Google Scholar
Novoseltsev VN, Michalski AI, Novoseltseva JA, Yashin AI, Carey JR, Ellis AM. An age-structured extension to the vectorial capacity model. PLoS One. 2012;7:e39479.
Article
CAS
PubMed
PubMed Central
Google Scholar
Styer LM, Carey JR, Wang JL, Scott TW. Mosquitoes do senesce: departure from the paradigm of constant mortality. Am J Trop Med Hyg. 2007;76:111–7.
PubMed
PubMed Central
Google Scholar
Pietri JE, Cheung KW, Luckhart S. Knockdown of mitogen-activated protein kinase (MAPK) signaling in the midgut of Anopheles stephensi mosquitoes using antisense morpholinos. Insect Mol Biol. 2014;23:558–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Boissière A, Gimonneau G, Tchioffo MT, Abate L, Bayibeki A, Awono-Ambéné PH, et al. Application of qPCR assay in the investigation susceptibility to malaria infection of the M and S molecular forms of An. gambiae s.s. In Cameroon. PLoS One. 2013;8:e54820.
Moreira CK, Marrelli MT, Jacobs-Lorena M. Gene expression in Plasmodium: from gametocytes to sporozoites. Int J Parasitol. 2004;34:1431–40.
Article
CAS
PubMed
Google Scholar
Berry A, Deymier C, Sertorio M, Witkowski B, Benoit-Vical F. Pfs 16 pivotal role in Plasmodium falciparum gametocytogenesis: a potential antiplasmodial drug target. Exp Parasitol. 2009;121:189–92.
Article
CAS
PubMed
Google Scholar
Meis JF, Ponnudurai T. Ultrastructural studies on the interaction of Plasmodium falciparum ookinetes with the midgut epithelium of Anopheles stephensi mosquitoes. Parasitol Res. 1987;73:500–6.
Article
CAS
PubMed
Google Scholar
Magnone M, Ameri P, Salis A, Andraghetti G, Emionite L, Murialdo G, et al. Microgram amounts of abscisic acid in fruit extracts improve glucose tolerance and reduce insulinemia in rats and in humans. FASEB J. 2015;29:4783–93.
Article
CAS
PubMed
Google Scholar
Qi CC, Zhang Z, Fang H, Liu J, Zhou N, Ge JF, et al. Antidepressant effects of abscisic acid mediated by the downregulation of corticotrophin-releasing hormone gene expression in rats. Int J Neuropsychopharmacol. 2014;18:pyu006.
PubMed
PubMed Central
Google Scholar
Leon J, Castillo MC, Coego A, Lozano-Juste J, Mir R. Diverse functional interactions between nitric oxide and abscisic acid in plant development and responses to stress. J Exp Bot. 2014;65:907–21.
Article
CAS
PubMed
Google Scholar
Gomez-Cadenas A, Vives V, Zandalinas SI, Manzi M, Sanchez-Perez AM, Perez-Clemente RM, Arbona V. Abscisic acid: a versatile phytohormone in plant signaling and beyond. Curr Protein Pept Sci. 2015;16:413–34.
Article
CAS
PubMed
Google Scholar
Maurer U, Preiss F, Brauns-Schubert P, Schlicher L, Charvet C. GSK-3 - at the crossroads of cell death and survival. J Cell Sci. 2014;127:1369–78.
Article
CAS
PubMed
Google Scholar
Lim J, Gowda DC, Krishnegowda G, Luckhart S. Induction of nitric oxide synthase in Anopheles stephensi by Plasmodium falciparum: mechanism of signaling and the role of parasite glycosylphosphatidylinositols. Infect Immun. 2005;73:2778–89.
Article
CAS
PubMed
PubMed Central
Google Scholar
Youn JH, Kim TW. Functional insights of plant GSK3-like kinases: multi-taskers in diverse cellular signal transduction pathways. Mol Plant. 2015;8:552–65.
Article
CAS
PubMed
Google Scholar
Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, et al. Inhibition of AMPK catabolic action by GSK3. Mol Cell. 2013;50:407–19.
Article
CAS
PubMed
PubMed Central
Google Scholar
Singh J, Suhail H, Giri S. Loss of AMP-activated protein kinase induces mitochondrial dysfunction and proinflammatory response in unstimulated Abcd1-knockout mice mixed glial cells. Mediat Inflamm. 2015;2015:176983.
Article
Google Scholar
Zaha VG, Qi D, Su KN, Palmeri M, Lee HY, Hu X, et al. AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia. J Mol Cell Cardiol. 2016;91:104–13.
Article
CAS
PubMed
Google Scholar
Micchelli CA, Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature. 2005;439:475–9.
Article
PubMed
Google Scholar
Ohlstein B, Spradling A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature. 2005;439:470–4.
Article
PubMed
Google Scholar
Suzuki K, Ohsumi Y. Molecular machinery of autophagosome formation in yeast Saccharomyces cerevisiae. FEBS Lett. 2007;581:2156–61.
Article
CAS
PubMed
Google Scholar
Clifton ME, Noriega FG. Nutrient limitation results in juvenile hormone-mediated resorption of previtellogenic ovarian follicles in mosquitoes. J Insect Physiol. 2011;57:1274–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Canyon DV, Hii JLK, Muller R. Effect of diet on biting, oviposition, and survival of Aedes aegypti (Diptera: Culicidae). J Med Entomol. 1999;36:301–8.
Article
CAS
PubMed
Google Scholar
Dawes EJ, Churcher TS, Zhuang S, Sinden S, Sinden RE, Basáñez MG. Anopheles mortality is both age- and Plasmodium-density dependent: implications for malaria transmission. Malar J. 2009;8:228.
Article
PubMed
PubMed Central
Google Scholar
Brown MR, Clark KD, Gulia M, Zhao Z, Garczynski SF, Crim JW, et al. An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti. Proc Natl Acad Sci USA. 2008;105:5716–21.
De Man W, De Loof A, Briers T, Huybrechts R. Effect of abscisic acid on vitellogenesis in Sarcophaga bullata. Entomol Exp Appl. 1981;29:259–67.
Article
Google Scholar
Finkelstein RR, Rock CD. Abscisic acid biosynthesis and response. Arabidopsis Book. 2002;1:e0058.
Vanhee C, Zapotoczny G, Masquelier D, Ghislain M, Batoko H. The Arabidopsis multistress regulator TSPO is a heme binding membrane protein and a potential scavenger of porphyrins via an autophagy-dependent degradation mechanism. Plant Cell. 2011;23:785–805.
Magnone M, Bruzzone S, Guida L, Damonte G, Millo E, Scarfi S, et al. Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis. J Biol Chem. 2009;284:17808–18.
Article
CAS
PubMed
PubMed Central
Google Scholar
Magnone M, Sturla L, Jacchetti E, Scarfi S, Bruzzone S, Usai C, et al. Autocrine abscisic acid plays a key role in quartz-induced macrophage activation. FASEB J. 2012;26:1261–71.
Article
CAS
PubMed
Google Scholar
Scarfi S, Fresia C, Ferraris C, Bruzzone S, Fruscione F, Usai C, et al. The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose. Stem Cells. 2009;27:2469–77.
Article
CAS
PubMed
Google Scholar
Medunjanin S, Schleithoff L, Fiegehenn C, Weinert S, Zuschratter W, Braun-Dullaeus RC. GSK-3β controls NF-kappaB activity via IKKγ/NEMO. Sci Rep. 2016;6:38553.
Article
CAS
PubMed
PubMed Central
Google Scholar
Salminen A, Hyttinen JM, Kaarniranta K. AMPK-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med. 2011;89:667–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Beurel E, Michalek SM, Jope RS. Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). Trends Immunol. 2010;31:24–31.
Article
CAS
PubMed
Google Scholar
Chang YT, Chen CL, Lin CF, Lu SL, Cheng MH, Kuo CF, Lin YS. Regulatory role of GSK-3β on NF-κB, nitric oxide, and TNF-α in group a streptococcal infection. Mediat Inflamm. 2013;2013:720689.
Article
Google Scholar
Yuskaitis CJ, Jope RS. Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity. Cell Signal. 2009;21:264–73.
Article
CAS
PubMed
Google Scholar
Chen H, Yang S, Yang Z, Ma L, Jiang D, Mao J, et al. Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. J Cell Biochem. 2007;102:1281–9.
Article
CAS
PubMed
Google Scholar
Alers S, Löffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol. 2012;32:2–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Young MM, Takahashi Y, Khan O, Park S, Hori T, Yun J, et al. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J Biol Chem. 2012;287:12455–68.
Article
CAS
PubMed
PubMed Central
Google Scholar
Amir M, Zhao E, Fontana L, Rosenberg H, Tanaka K, Gao G, Czaja MJ. Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation. Cell Death Differ. 2013;20:878–87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kakani P, Suman S, Gupta L, Kumar S. Ambivalent outcomes of cell apoptosis: a barrier or blessing in malaria progression. Front Microbiol. 2016;7:302.
Article
PubMed
PubMed Central
Google Scholar
Tilstra JS, Clauson CL, Niedernhofer LJ, Robbins PD. NF-κB in aging and disease. Aging Dis. 2011;2:449–65.
PubMed
PubMed Central
Google Scholar
Mehrpour M, Esclatine A, Beau I, Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Res. 2010;20:748–62.
Article
PubMed
Google Scholar
Corby-Harris V, Drexler A, Watkins de Jong L, Antonova Y, Pakpour N, Ziegler R, et al. Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopheles
stephensi mosquitoes. PLoS Pathog. 2010;6:e1001003.
Crozet P, Margalha L, Confraria A, Rodrigues A, Martinho C, Adamo M, et al. Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Front Plant Sci. 2014;5:190.
Article
PubMed
PubMed Central
Google Scholar
Sakthivel P, Sharma N, Klahn P, Gereke M, Bruder D. Abscisic acid: a phytohormone and mammalian cytokine as a novel pharmacon with potential for future development into clinical applications. Curr Med Chem. 2016;23:1549–70.
Article
CAS
PubMed
Google Scholar