Siris ES, Adler R, Bilezikian J, Bolognese M, Dawson-Hughes B, Favus MJ, et al. The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group. Osteoporos Int. 2014;25:1439–43. https://doi.org/10.1007/s00198-014-2655-z.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang TL, Shen H, Liu A, Dong SS, Zhang L, Deng FY, et al. A road map for understanding molecular and genetic determinants of osteoporosis. Nat Rev Endocrinol. 2020;16:91–103. https://doi.org/10.1038/s41574-019-0282-7.
Article
PubMed
Google Scholar
Clynes MA, Harvey NC, Curtis EM, Fuggle NR, Dennison EM, Cooper C. The epidemiology of osteoporosis. Br Med Bull. 2020;133:105–17. https://doi.org/10.1093/bmb/ldaa005.
Article
PubMed
Google Scholar
Bouvard B, Annweiler C, Legrand E. Osteoporosis in older adults. Joint Bone Spine. 2021;88:105135. https://doi.org/10.1016/j.jbspin.2021.105135.
Article
PubMed
Google Scholar
Harvey NC, Glüer CC, Binkley N, McCloskey EV, Brandi ML, Cooper C, et al. Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice. Bone. 2015;78:216–24. https://doi.org/10.1016/j.bone.2015.05.016.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang J, Morgan SL, Saag KG. Osteopenia: debates and dilemmas. Curr Rheumatol Rep. 2013;15:384. https://doi.org/10.1007/s11926-013-0384-5.
Article
PubMed
Google Scholar
Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8:136. https://doi.org/10.1007/s11657-013-0136-1.
Article
CAS
PubMed
PubMed Central
Google Scholar
Karaguzel G, Holick MF. Diagnosis and treatment of osteopenia. Rev Endocr Metab Disord. 2010;11:237–51. https://doi.org/10.1007/s11154-010-9154-0.
Article
CAS
PubMed
Google Scholar
Maria S, Witt-Enderby PA. Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures. J Pineal Res. 2014;56:115–25. https://doi.org/10.1111/jpi.12116.
Article
CAS
PubMed
Google Scholar
Baccaro LF, Conde DM, Costa-Paiva L, Pinto-Neto AM. The epidemiology and management of postmenopausal osteoporosis: a viewpoint from Brazil. Clin Interv Aging. 2015;10:583–91. https://doi.org/10.2147/cia.S54614.
Article
PubMed
PubMed Central
Google Scholar
Anagnostis P, Karagiannis A, Kakafika AI, Tziomalos K, Athyros VG, Mikhailidis DP. Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities? Osteoporos Int. 2009;20:197–207. https://doi.org/10.1007/s00198-008-0648-5.
Article
CAS
PubMed
Google Scholar
Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005;293:2257–64. https://doi.org/10.1001/jama.293.18.2257.
Article
CAS
PubMed
Google Scholar
Wong PK, Christie JJ, Wark JD. The effects of smoking on bone health. Clin Sci (Lond). 2007;113:233–41. https://doi.org/10.1042/cs20060173.
Article
CAS
Google Scholar
Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest. 2005;115:3318–25. https://doi.org/10.1172/jci27071.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ioannidis JP, Ralston SH, Bennett ST, Brandi ML, Grinberg D, Karassa FB, et al. Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA. 2004;292:2105–14. https://doi.org/10.1001/jama.292.17.2105.
Article
CAS
PubMed
Google Scholar
Li W, Wei C, Xu L, Yu B, Chen Y, Lu D, et al. Schistosome infection promotes osteoclast-mediated bone loss. PLoS Pathog. 2021;17:e1009462. https://doi.org/10.1371/journal.ppat.1009462.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dubey JP. The history of Toxoplasma gondii–the first 100 years. J Eukaryot Microbiol. 2008;55:467–75. https://doi.org/10.1111/j.1550-7408.2008.00345.x.
Article
PubMed
Google Scholar
Coppens I. Toxoplasma, or the discovery of a heterophage. Trends Parasitol. 2014;30:467–9. https://doi.org/10.1016/j.pt.2014.08.005.
Article
CAS
PubMed
Google Scholar
Xiao J, Yolken RH. Strain hypothesis of Toxoplasma gondii infection on the outcome of human diseases. Acta Physiol (Oxf). 2015;213:828–45. https://doi.org/10.1111/apha.12458.
Article
CAS
Google Scholar
Liu Q, Wang ZD, Huang SY, Zhu XQ. Diagnosis of toxoplasmosis and typing of Toxoplasma gondii. Parasit Vectors. 2015;8:292. https://doi.org/10.1186/s13071-015-0902-6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hakimi MA, Olias P, Sibley LD. Toxoplasma effectors targeting host signaling and transcription. Clin Microbiol Rev. 2017;30:615–45. https://doi.org/10.1128/cmr.00005-17.
Article
PubMed
PubMed Central
Google Scholar
Gulinello M, Acquarone M, Kim JH, Spray DC, Barbosa HS, Sellers R, et al. Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology. Microbes Infect. 2010;12:528–37. https://doi.org/10.1016/j.micinf.2010.03.009.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang ZD, Wang SC, Liu HH, Ma HY, Li ZY, Wei F, et al. Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis. Lancet HIV. 2017;4:e177–88. https://doi.org/10.1016/s2352-3018(17)30005-x.
Article
PubMed
Google Scholar
Zheng J, Jia H, Zheng Y. Knockout of leucine aminopeptidase in Toxoplasma gondii using CRISPR/Cas9. Int J Parasitol. 2015;45:141–8. https://doi.org/10.1016/j.ijpara.2014.09.003.
Article
CAS
PubMed
Google Scholar
Wang T, Han Y, Pan Z, Wang H, Yuan M, Lin H. Seroprevalence of Toxoplasma gondii infection in blood donors in mainland China: a systematic review and meta-analysis. Parasite. 2018;25:36. https://doi.org/10.1051/parasite/2018037.
Article
PubMed
PubMed Central
Google Scholar
Harker KS, Ueno N, Lodoen MB. Toxoplasma gondii dissemination: a parasite’s journey through the infected host. Parasite Immunol. 2015;37:141–9. https://doi.org/10.1111/pim.12163.
Article
CAS
PubMed
Google Scholar
Bougdour A, Tardieux I, Hakimi MA. Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression. Cell Microbiol. 2014;16:334–43. https://doi.org/10.1111/cmi.12255.
Article
CAS
PubMed
Google Scholar
Liu Q, Wei F, Gao S, Jiang L, Lian H, Yuan B, et al. Toxoplasma gondii infection in pregnant women in China. Trans R Soc Trop Med Hyg. 2009;103:162–6. https://doi.org/10.1016/j.trstmh.2008.07.008.
Article
PubMed
Google Scholar
Cong W, Liu GH, Meng QF, Dong W, Qin SY, Zhang FK, et al. Toxoplasma gondii infection in cancer patients: prevalence, risk factors, genotypes and association with clinical diagnosis. Cancer Lett. 2015;359:307–13. https://doi.org/10.1016/j.canlet.2015.01.036.
Article
CAS
PubMed
Google Scholar
Han Y, Nie L, Ye X, Zhou Z, Huang S, Zeng C, et al. The association between Toxoplasma gondii infection and hypertensive disorders in T2DM patients: a case-control study in the Han Chinese population. Parasitol Res. 2018;117:689–95. https://doi.org/10.1007/s00436-017-5737-y.
Article
PubMed
Google Scholar
Miman O, Mutlu EA, Ozcan O, Atambay M, Karlidag R, Unal S. Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder? Psychiatry Res. 2010;177:263–5. https://doi.org/10.1016/j.psychres.2009.12.013.
Article
PubMed
Google Scholar
Sutterland AL, Fond G, Kuin A, Koeter MW, Lutter R, van Gool T, et al. Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis. Acta Psychiatr Scand. 2015;132:161–79. https://doi.org/10.1111/acps.12423.
Article
CAS
PubMed
Google Scholar
Bayani M, Riahi SM, Bazrafshan N, Ray Gamble H, Rostami A. Toxoplasma gondii infection and risk of Parkinson and Alzheimer diseases: a systematic review and meta-analysis on observational studies. Acta Trop. 2019;196:165–71. https://doi.org/10.1016/j.actatropica.2019.05.015.
Article
PubMed
Google Scholar
Koseoglu E, Yazar S, Koc I. Is Toxoplasma gondii a causal agent in migraine? Am J Med Sci. 2009;338:120–2. https://doi.org/10.1097/MAJ.0b013e31819f8cac.
Article
PubMed
Google Scholar
Kamal AM, Kamal AM, Abd El-Fatah AS, Rizk MM, Hassan EE. Latent toxoplasmosis is associated with depression and suicidal behavior. Arch Suicide Res. 2020. https://doi.org/10.1080/13811118.2020.1838368.
Article
PubMed
Google Scholar
Beste C, Getzmann S, Gajewski PD, Golka K, Falkenstein M. Latent Toxoplasma gondii infection leads to deficits in goal-directed behavior in healthy elderly. Neurobiol Aging. 2014;35:1037–44. https://doi.org/10.1016/j.neurobiolaging.2013.11.012.
Article
PubMed
Google Scholar
Hwang JS, Chan DC, Chen JF, Cheng TT, Wu CH, Soong YK, et al. Clinical practice guidelines for the prevention and treatment of osteoporosis in Taiwan: summary. J Bone Miner Metab. 2014;32:10–6. https://doi.org/10.1007/s00774-013-0495-0.
Article
PubMed
Google Scholar
Sözen T, Özışık L, Başaran N. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4:46–56. https://doi.org/10.5152/eurjrheum.2016.048.
Article
PubMed
Google Scholar
Carlos F, Clark P, Galindo-Suárez RM, Chico-Barba LG. Health care costs of osteopenia, osteoporosis, and fragility fractures in Mexico. Arch Osteoporos. 2013;8:125. https://doi.org/10.1007/s11657-013-0125-4.
Article
PubMed
Google Scholar
Hamrick I, Cao Q, Agbafe-Mosley D, Cummings DM. Osteoporosis healthcare disparities in postmenopausal women. J Womens Health (Larchmt). 2012;21:1232–6. https://doi.org/10.1089/jwh.2012.3812.
Article
Google Scholar
Kanis JA, McCloskey EV, Johansson H, Oden A, Melton LJ 3rd, Khaltaev N. A reference standard for the description of osteoporosis. Bone. 2008;42:467–75. https://doi.org/10.1016/j.bone.2007.11.001.
Article
CAS
PubMed
Google Scholar
Laster AJ. Dual-energy x-ray absorptiometry: overused, neglected, or just misunderstood? N C Med J. 2014;75:132–6. https://doi.org/10.18043/ncm.75.2.132.
Article
PubMed
Google Scholar
Consensus development conference. diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 1993;94:646–50. https://doi.org/10.1016/0002-9343(93)90218-e.
Article
Google Scholar
Pan M, Lyu C, Zhao J, Shen B. Sixty years (1957–2017) of research on toxoplasmosis in China—an overview. Front Microbiol. 2017;8:1825. https://doi.org/10.3389/fmicb.2017.01825.
Article
PubMed
PubMed Central
Google Scholar
Wang Y, Ding H, Wang X, Wei Z, Feng S. Associated Factors for Osteoporosis and Fracture in Chinese Elderly. Med Sci Monit. 2019;25:5580–8. https://doi.org/10.12659/msm.914182.
Article
PubMed
PubMed Central
Google Scholar
Mo X, Zhao S, Wen Z, Lin W, Chen Z, Wang Z, et al. High prevalence of osteoporosis in patients undergoing spine surgery in China. BMC Geriatr. 2021;21:361. https://doi.org/10.1186/s12877-021-02313-8.
Article
PubMed
PubMed Central
Google Scholar
Ji MX, Yu Q. Primary osteoporosis in postmenopausal women. Chronic Dis Transl Med. 2015;1:9–13. https://doi.org/10.1016/j.cdtm.2015.02.006.
Article
PubMed
PubMed Central
Google Scholar
Dennison EM, Syddall HE, Aihie Sayer A, Martin HJ, Cooper C. Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study. QJM. 2007;100:297–303. https://doi.org/10.1093/qjmed/hcm023.
Article
CAS
PubMed
Google Scholar
Kanis JA. Osteoporosis and osteopenia. J Bone Miner Res. 1990;5:209–11. https://doi.org/10.1002/jbmr.5650050302.
Article
CAS
PubMed
Google Scholar
Leles D, Lobo A, Rhodes T, Millar PR, Amendoeira MR, Araújo A. Recovery of Toxoplasma gondii DNA in experimentally mummified skin and bones: prospects for paleoparasitological studies to unveil the origin of toxoplasmosis. Exp Parasitol. 2016;168:51–5. https://doi.org/10.1016/j.exppara.2016.06.003.
Article
CAS
PubMed
Google Scholar
Lopes CS, Silva TL, de Almeida JCN, Costa LVS, Mineo TWP, Mineo JR. Transmission of Toxoplasma gondii infection due to bone marrow transplantation: validation by an experimental model. Front Med (Lausanne). 2019;6:227. https://doi.org/10.3389/fmed.2019.00227.
Article
Google Scholar
Portes J, Barrias E, Travassos R, Attias M, de Souza W. Toxoplasma gondii mechanisms of entry into host cells. Front Cell Infect Microbiol. 2020;10:294. https://doi.org/10.3389/fcimb.2020.00294.
Article
CAS
PubMed
PubMed Central
Google Scholar
Robling AG, Bonewald LF. The osteocyte: new insights. Annu Rev Physiol. 2020;82:485–506. https://doi.org/10.1146/annurev-physiol-021119-034332.
Article
CAS
PubMed
PubMed Central
Google Scholar
Place DE, Malireddi RKS, Kim J, Vogel P, Yamamoto M, Kanneganti TD. Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins. Nat Commun. 2021;12:496. https://doi.org/10.1038/s41467-020-20807-8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Amarasekara DS, Yun H, Kim S, Lee N, Kim H, Rho J. Regulation of osteoclast differentiation by cytokine networks. Immune Netw. 2018;18:e8. https://doi.org/10.4110/in.2018.18.e8.
Article
PubMed
PubMed Central
Google Scholar
Bi H, Chen X, Gao S, Yu X, Xiao J, Zhang B, et al. Key triggers of osteoclast-related diseases and available strategies for targeted therapies: a review. Front Med (Lausanne). 2017;4:234. https://doi.org/10.3389/fmed.2017.00234.
Article
Google Scholar
Teitelbaum SL. Bone resorption by osteoclasts. Science. 2000;289:1504–8. https://doi.org/10.1126/science.289.5484.1504.
Article
CAS
PubMed
Google Scholar
Sasai M, Pradipta A, Yamamoto M. Host immune responses to Toxoplasma gondii. Int Immunol. 2018;30:113–9. https://doi.org/10.1093/intimm/dxy004.
Article
CAS
PubMed
Google Scholar
Precision evaluation of dual X-ray absorptiometry (iDXA) measurements. 2009;43;12:1291–4. https://www.osti.gov/etdeweb/biblio/21404906. Accessed 18 Dec 2021
Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, et al. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res. 2006;21:124–31. https://doi.org/10.1359/jbmr.050916.
Article
PubMed
Google Scholar
Barragan A, Sibley LD. Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. J Exp Med. 2002;195:1625–33. https://doi.org/10.1084/jem.20020258.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang L, Chen H, Liu D, Huo X, Gao J, Song X, et al. Genotypes and mouse virulence of Toxoplasma gondii isolates from animals and humans in China. PLoS ONE. 2013;8: e53483. https://doi.org/10.1371/journal.pone.0053483.
Article
CAS
PubMed
PubMed Central
Google Scholar